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    Iars2 isoleucine-tRNA synthetase 2, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 381314, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Iars2provided by MGI
    Official Full Name
    isoleucine-tRNA synthetase 2, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1919586
    See related
    Ensembl:ENSMUSG00000026618 AllianceGenome:MGI:1919586
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010002H18Rik
    Summary
    Predicted to enable isoleucine-tRNA ligase activity. Predicted to be involved in isoleucyl-tRNA aminoacylation and mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 24.1), subcutaneous fat pad adult (RPKM 16.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Iars2 in Genome Data Viewer
    Location:
    1 H5; 1 89.48 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (185018839..185061615, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (185286642..185329419, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RAB3 GTPase activating protein subunit 2 Neighboring gene small nucleolar RNA, H/ACA box 36B Neighboring gene predicted gene, 34882 Neighboring gene microRNA 664 Neighboring gene RIKEN cDNA 2010103J01 gene Neighboring gene microRNA 194-1 Neighboring gene STARR-seq mESC enhancer starr_03326 Neighboring gene microRNA 215 Neighboring gene STARR-seq mESC enhancer starr_03328 Neighboring gene 3'(2'), 5'-bisphosphate nucleotidase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4403 Neighboring gene STARR-positive B cell enhancer ABC_E3350 Neighboring gene glutamyl-prolyl-tRNA synthetase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article
    2. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63429

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isoleucine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isoleucine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoleucyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isoleucyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    isoleucine--tRNA ligase, mitochondrial
    Names
    ileRS
    isoleucyl-tRNA synthetase, mitochondrial
    NP_941055.1
    XP_006497242.1
    XP_006497243.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198653.3 → NP_941055.1  isoleucine--tRNA ligase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_941055.1

      Status: VALIDATED

      Source sequence(s)
      AK043590, AK048653
      Consensus CDS
      CCDS15596.1
      UniProtKB/Swiss-Prot
      Q3TKT8, Q8BIJ0, Q8BIJ6, Q8BIP3
      Related
      ENSMUSP00000027921.5, ENSMUST00000027921.11
      Conserved Domains (5) summary
      cd07960
      Location:711 → 890
      Anticodon_Ia_Ile_BEm; Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases
      PRK05743
      Location:60 → 1009
      ileS; isoleucyl-tRNA synthetase; Reviewed
      pfam06827
      Location:985 → 1006
      zf-FPG_IleRS; Zinc finger found in FPG and IleRS
      pfam13603
      Location:266 → 412
      tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2
      cl00015
      Location:472 → 708
      nt_trans; nucleotidyl transferase superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      185018839..185061615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497180.5 → XP_006497243.1  isoleucine--tRNA ligase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006497243.1

      UniProtKB/TrEMBL
      E9PWN3, Q8BIL6
      Conserved Domains (1) summary
      PRK05743
      Location:60 → 546
      ileS; isoleucyl-tRNA synthetase; Reviewed

    2. XM_006497179.5 → XP_006497242.1  isoleucine--tRNA ligase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006497242.1

      UniProtKB/TrEMBL
      E9PWN3, Q8BIL6
      Related
      ENSMUSP00000106601.4, ENSMUST00000110974.4
      Conserved Domains (1) summary
      PRK05743
      Location:60 → 546
      ileS; isoleucyl-tRNA synthetase; Reviewed
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BIJ6.1 GenPept UniProtKB/Swiss-Prot:Q8BIJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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