Psi P-element somatic inhibitor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Psiprovided by FlyBase
Official Full Name: P-element somatic inhibitorprovided by FlyBase
Primary source: FLYBASE:FBgn0014870
Locus tag: Dmel_CG8912
See related: AllianceGenome:FB:FBgn0014870
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8912; Dmel\CG8912; EG:EG0003.2; PSI
Summary: Enables mRNA binding activity. Involved in mRNA processing; regulation of mRNA splicing, via spliceosome; and spermatogenesis. Located in nucleus. Is expressed in several structures, including adult head; brain; larval central nervous system; larval ventral nerve cord; and ovary. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to several human genes including KHSRP (KH-type splicing regulatory protein) and FUBP1 (far upstream element binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 53D14-53D14; 2-80 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16861321..16867714, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12748826..12755219, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Psi promotes Drosophila wing growth via direct transcriptional activation of cell cycle targets and repression of growth inhibitors.
Title: Psi promotes Drosophila wing growth via direct transcriptional activation of cell cycle targets and repression of growth inhibitors.
PSI regulates the period of Drosophila circadian rhythms and circadian behavior phase during temperature cycling through its modulation of the tim splicing pattern.
Title: Drosophila PSI controls circadian period and the phase of circadian behavior under temperature cycle via tim splicing.
the key target of the Psi/MED network in controlling developmentally regulated tissue growth is the transcription factor MYC.
Title: Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth.
Thus, PSI imposes a specific mode of regulatory control within the neuronal circuit controlling courtship, even though it is broadly expressed in the fly nervous system.
Title: The PSI-U1 snRNP interaction regulates male mating behavior in Drosophila.
Drosophila splicing factor P element Somatic Inhibitor (PSI) is phosphorylated at at least two different sites by at minimum two different kinases, casein kinase II (CK II) and tousled-like kinase (tlk).
Title: The Drosophila splicing factor PSI is phosphorylated by casein kinase II and tousled-like kinase.
PSI is required for Drosophila viability, male fertility, and cellular mRNA processing
Title: The KH-type RNA-binding protein PSI is required for Drosophila viability, male fertility, and cellular mRNA processing.
PSI requires multiple tandem KH domains for specific and high-affinity recognition of substrate RNA
Title: Distinct contributions of KH domains to substrate binding affinity of Drosophila P-element somatic inhibitor protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c16862507-16862465 mobile_element_type = transposon:INE-1{}4556

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: P-element somatic inhibitor

Names: CG8912-PA; CG8912-PB; CG8912-PC; CG8912-PD; CG8912-PE; P element somatic inhibitor; P-element somatic; P-element somatic inhibitor protein; Psi-PA; Psi-PB; Psi-PC; Psi-PD; Psi-PE; inhibitor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

16861321..16867714 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166200.3 → NP_725623.2 P-element somatic inhibitor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725623.2

Status: REVIEWED

UniProtKB/TrEMBL

A1ZAK9, L0CPZ4

Related

FBpp0086221

Conserved Domains (4) summary

smart00322
Location:40 → 105

KH; K homology RNA-binding domain

cd00105
Location:237 → 300

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:134 → 196

KH_1; KH domain

pfam09005
Location:511 → 539

DUF1897; Domain of unknown function (DUF1897)
NM_001414151.1 → NP_001401009.1 P-element somatic inhibitor, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A1ZAK8, O96828
NM_001414150.1 → NP_001401008.1 P-element somatic inhibitor, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A1ZAK9, L0CPZ4
NM_206140.2 → NP_995862.1 P-element somatic inhibitor, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995862.1

Status: REVIEWED

UniProtKB/TrEMBL

A1ZAK8, O96828

Conserved Domains (4) summary

smart00322
Location:120 → 185

KH; K homology RNA-binding domain

cd00105
Location:317 → 380

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:214 → 276

KH_1; KH domain

pfam09005
Location:591 → 619

DUF1897; Domain of unknown function (DUF1897)
NM_057775.4 → NP_477123.1 P-element somatic inhibitor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477123.1

Status: REVIEWED

UniProtKB/TrEMBL

A1ZAK7, O96828

Related

FBpp0086220

Conserved Domains (4) summary

smart00322
Location:120 → 185

KH; K homology RNA-binding domain

cd00105
Location:317 → 380

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:214 → 276

KH_1; KH domain

pfam09005
Location:591 → 619

DUF1897; Domain of unknown function (DUF1897)