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    Dock6 dedicator of cytokinesis 6 [ Mus musculus (house mouse) ]

    Gene ID: 319899, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dock6provided by MGI
    Official Full Name
    dedicator of cytokinesis 6provided by MGI
    Primary source
    MGI:MGI:1914789
    See related
    Ensembl:ENSMUSG00000032198 AllianceGenome:MGI:1914789
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1395; 2410095B20Rik; 4931431C02Rik; C330023D02Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rho protein signal transduction. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including forelimb bud; head mesenchyme derived from neural crest; limb; nervous system; and spleen. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human DOCK6 (dedicator of cytokinesis 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 44.6), ovary adult (RPKM 27.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dock6 in Genome Data Viewer
    Location:
    9 A3; 9 7.89 cM
    Exon count:
    50
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21711476..21764006, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21800180..21852718, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1379 Neighboring gene STARR-seq mESC enhancer starr_23515 Neighboring gene SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) Neighboring gene KN motif and ankyrin repeat domains 2 Neighboring gene predicted gene, 39305 Neighboring gene microRNA 7083 Neighboring gene STARR-seq mESC enhancer starr_23526 Neighboring gene angiopoietin-like 8 Neighboring gene STARR-seq mESC enhancer starr_23527 Neighboring gene RAB3D, member RAS oncogene family Neighboring gene transmembrane protein 205 Neighboring gene coiled-coil domain containing 159

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams-Oliver syndrome. Shaheen R, et al. Am J Hum Genet, 2011 Aug 12. PMID 21820096, Free PMC Article
    2. Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth. Miyamoto Y, et al. Exp Cell Res, 2007 Feb 15. PMID 17196961
    3. Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons. Miyamoto Y, et al. Sci Signal, 2013 Mar 5. PMID 23462102
    4. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. phosphorylation status of Dock6 at Ser(1194) determines whether it promotes axon extension or branching in sensory neurons, revealing interplay between kinase and phosphatase action on a Rho-GEF during axon growth
      Title: Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons.
    2. Dock6 is the GEF specific for both Rac1 and Cdc42 and may be one of physiological regulators of neurite outgrowth.
      Title: Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413912.1 → NP_001400841.1  dedicator of cytokinesis protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161371, AC166992
      UniProtKB/Swiss-Prot
      E9QKQ0, Q3UM59, Q6PFY0, Q8BJS1, Q8VDR9, Q9D461
      Related
      ENSMUSP00000034728.9, ENSMUST00000034728.9

    2. NM_177030.4 → NP_796004.2  dedicator of cytokinesis protein 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC161371, AC166992
      Consensus CDS
      CCDS40555.1
      UniProtKB/TrEMBL
      A0A1L1SQR4, Q6ZPS1
      Related
      ENSMUSP00000149156.2, ENSMUST00000217336.2
      Conserved Domains (3) summary
      cd08696
      Location:545 → 722
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam11878
      Location:65 → 155
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1656 → 2078
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21711476..21764006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155058.1 → XP_036010951.1  dedicator of cytokinesis protein 6 isoform X7

      UniProtKB/TrEMBL
      Q6ZPS1
      Conserved Domains (3) summary
      cd08696
      Location:545 → 722
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam11878
      Location:48 → 157
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1590 → 2012
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    2. XM_017313426.3 → XP_017168915.1  dedicator of cytokinesis protein 6 isoform X1

      UniProtKB/TrEMBL
      Q6ZPS1
      Conserved Domains (3) summary
      cd08696
      Location:545 → 722
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam11878
      Location:48 → 157
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1656 → 2078
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    3. XM_036155057.1 → XP_036010950.1  dedicator of cytokinesis protein 6 isoform X4

      UniProtKB/TrEMBL
      Q6ZPS1
      Conserved Domains (3) summary
      cd08696
      Location:545 → 722
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam11878
      Location:48 → 157
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1590 → 2012
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    4. XM_011242553.3 → XP_011240855.1  dedicator of cytokinesis protein 6 isoform X3

      UniProtKB/TrEMBL
      Q6ZPS1
      Conserved Domains (3) summary
      cd08696
      Location:545 → 722
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam11878
      Location:48 → 157
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1621 → 2043
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    5. XM_011242552.3 → XP_011240854.1  dedicator of cytokinesis protein 6 isoform X2

      UniProtKB/TrEMBL
      Q6ZPS1
      Conserved Domains (3) summary
      cd08696
      Location:545 → 722
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam11878
      Location:48 → 157
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1625 → 2047
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    6. XM_006510422.3 → XP_006510485.1  dedicator of cytokinesis protein 6 isoform X5

      UniProtKB/TrEMBL
      Q6ZPS1
      Conserved Domains (3) summary
      cd08696
      Location:453 → 630
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam11878
      Location:13 → 65
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1564 → 1986
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    7. XM_030244416.2 → XP_030100276.1  dedicator of cytokinesis protein 6 isoform X10

      Conserved Domains (1) summary
      cl06123
      Location:823 → 1245
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    8. XM_017313427.3 → XP_017168916.1  dedicator of cytokinesis protein 6 isoform X8

      UniProtKB/TrEMBL
      Q6ZPS1
      Conserved Domains (3) summary
      cd08696
      Location:545 → 722
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam11878
      Location:48 → 157
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1617 → 1760
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    9. XM_011242555.4 → XP_011240857.1  dedicator of cytokinesis protein 6 isoform X9

      Conserved Domains (2) summary
      cd08696
      Location:545 → 722
      C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      pfam11878
      Location:48 → 157
      DUF3398; Domain of unknown function (DUF3398)

    RNA

    1. XR_003947928.2 RNA Sequence

    2. XR_004935451.1 RNA Sequence

    3. XR_001778931.3 RNA Sequence

    4. XR_004935452.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDR9.4 GenPept UniProtKB/Swiss-Prot:Q8VDR9

    Gene LinkOut

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