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    Srp54a signal recognition particle 54A [ Mus musculus (house mouse) ]

    Gene ID: 24067, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srp54aprovided by MGI
    Official Full Name
    signal recognition particle 54Aprovided by MGI
    Primary source
    MGI:MGI:1346087
    See related
    Ensembl:ENSMUSG00000073079 AllianceGenome:MGI:1346087
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    54kDa; Srp54
    Summary
    Predicted to enable several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Predicted to contribute to GTPase activity. Predicted to be involved in several processes, including SRP-dependent cotranslational protein targeting to membrane, translocation; exocrine pancreas development; and neutrophil chemotaxis. Predicted to act upstream of or within SRP-dependent cotranslational protein targeting to membrane. Predicted to be located in cytoplasm and nucleus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in severe congenital neutropenia 8. Orthologous to human SRP54 (signal recognition particle 54). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 34.3), bladder adult (RPKM 29.5) and 26 other tissues See more
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    Genomic context

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    See Srp54a in Genome Data Viewer
    Location:
    12 C1; 12 23.86 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55127318..55162152)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55080476..55115367)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2700097O09 gene Neighboring gene predicted gene, 46350 Neighboring gene RNA polymerase II, polypeptide H Neighboring gene family with sequence similarity 177, member A Neighboring gene predicted gene 2436 Neighboring gene STARR-positive B cell enhancer mm9_chr12:56256085-56256386 Neighboring gene signal recognition particle 54B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The methionine-rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence. Zopf D, et al. EMBO J, 1990 Dec. PMID 1702385, Free PMC Article
    2. Structure of the signal recognition particle interacting with the elongation-arrested ribosome. Halic M, et al. Nature, 2004 Feb 26. PMID 14985753
    3. Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle. Bernstein HD, et al. Nature, 1989 Aug 10. PMID 2502718
    4. Isolation of genes identified in mouse renal proximal tubule by comparing different gene expression profiles. Takenaka M, et al. Kidney Int, 1998 Mar. PMID 9507200
    5. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 7S RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 7S RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables endoplasmic reticulum signal peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endoplasmic reticulum signal peptide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocrine pancreas development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in granulocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in granulocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neutrophil chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein targeting to ER ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    signal recognition particle 54 kDa protein
    Names
    54K subunit of signal recognition particle
    signal recognition particle subunit SRP54
    NP_001400559.1
    NP_001400560.1
    NP_001400561.1
    NP_001400562.1
    NP_036029.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413630.1 → NP_001400559.1  signal recognition particle 54 kDa protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157515
      UniProtKB/TrEMBL
      Q8C1Y6

    2. NM_001413631.1 → NP_001400560.1  signal recognition particle 54 kDa protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157515
      UniProtKB/TrEMBL
      Q8C1Y6

    3. NM_001413632.1 → NP_001400561.1  signal recognition particle 54 kDa protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC157515
      UniProtKB/TrEMBL
      Q8C1Y6

    4. NM_001413633.1 → NP_001400562.1  signal recognition particle 54 kDa protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157515
      UniProtKB/Swiss-Prot
      P14576, Q3UWX8, Q9CWH7, Q9D008
      UniProtKB/TrEMBL
      Q8C1Y6
      Related
      ENSMUSP00000021407.11, ENSMUST00000021407.11

    5. NM_011899.5 → NP_036029.2  signal recognition particle 54 kDa protein isoform 1

      See identical proteins and their annotated locations for NP_036029.2

      Status: VALIDATED

      Source sequence(s)
      AC157515
      Consensus CDS
      CCDS36449.1
      UniProtKB/Swiss-Prot
      P14576, Q3UWX8, Q9CWH7, Q9D008
      UniProtKB/TrEMBL
      Q8C1Y6
      Related
      ENSMUSP00000152764.2, ENSMUST00000220578.2
      Conserved Domains (1) summary
      TIGR01425
      Location:2 → 430
      SRP54_euk; signal recognition particle protein SRP54

    RNA

    1. NR_182177.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157515

    2. NR_182178.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157515

    3. NR_182179.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157515

    4. NR_182180.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157515

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      55127318..55162152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14576.2 GenPept UniProtKB/Swiss-Prot:P14576

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