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    LOC127271449 OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:209606917-209607516 [ Homo sapiens (human) ]

    Gene ID: 127271449, updated on 12-Sep-2024

    Summary

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    Gene symbol
    LOC127271449
    Gene description
    OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:209606917-209607516
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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    Genomic context

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    See LOC127271449 in Genome Data Viewer
    Location:
    chromosome: 1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (209433572..209434171)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (208680362..208680961)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (209606917..209607516)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:209546699-209547200 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:209547201-209547700 Neighboring gene long intergenic non-protein coding RNA 1698 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:209556921-209557668 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:209557669-209558417 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:209570036-209570918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:209572682-209573562 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:209576956-209578155 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:209601163-209602086 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:209606319-209606916 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:209608115-209608712 Neighboring gene MIR205 host gene Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:209621349-209622029 Neighboring gene microRNA 205 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:209622030-209622710 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:209625434-209626113 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:209626672-209627311 Neighboring gene uncharacterized LOC105372898 Neighboring gene MPRA-validated peak673 silencer Neighboring gene uncharacterized LOC105372899

    Genomic regions, transcripts, and products

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    Bibliography

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    Related articles in PubMed

    1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_093301.1 

      Range
      101..700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      209433572..209434171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      208680362..208680961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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