Ralgps2 Ral GEF with PH domain and SH3 binding motif 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ralgps2provided by MGI
Official Full Name: Ral GEF with PH domain and SH3 binding motif 2provided by MGI
Primary source: MGI:MGI:1925505
See related: Ensembl:ENSMUSG00000026594 AllianceGenome:MGI:1925505
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810020P17Rik; 2210408F11Rik; 4921528G01Rik; 9130014M22Rik
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; eye; limb bud; limb segment; and nervous system. Orthologous to human RALGPS2 (Ral GEF with PH domain and SH3 binding motif 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 13.7), CNS E14 (RPKM 8.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 G3; 1 67.71 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (156631736..156767422, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (156804166..156939850, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RalGPS2 was characterized.
Title: Functional analysis of RalGPS2, a murine guanine nucleotide exchange factor for RalA GTPase.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW046161 (e-PCR)
- UniSTS:164134

AU043409 (e-PCR)
- UniSTS:158869

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras-specific guanine nucleotide-releasing factor RalGPS2

Names: ral GEF with PH domain and SH3-binding motif 2; ralA exchange factor RalGPS2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159965.1 → NP_001153437.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform a

See identical proteins and their annotated locations for NP_001153437.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes the longest isoform (a). Variants 1, 2, and 3 all encode isoform a.

Source sequence(s)

AC138109, AK019543, AK033549, BC052663, CJ104104

Consensus CDS

CCDS15396.1

UniProtKB/Swiss-Prot

Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6

UniProtKB/TrEMBL

Q8C134

Related

ENSMUSP00000063872.7, ENSMUST00000063199.13

Conserved Domains (2) summary

smart00147
Location:45 → 286

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd13310
Location:466 → 581

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
NM_001159966.1 → NP_001153438.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform a

See identical proteins and their annotated locations for NP_001153438.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.

Source sequence(s)

AC138109, AK019543, AK033549

Consensus CDS

CCDS15396.1

UniProtKB/Swiss-Prot

Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6

UniProtKB/TrEMBL

Q8C134

Related

ENSMUSP00000130581.2, ENSMUST00000171292.8

Conserved Domains (2) summary

smart00147
Location:45 → 286

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd13310
Location:466 → 581

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
NM_001159967.1 → NP_001153439.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform b

See identical proteins and their annotated locations for NP_001153439.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC138109, AK169368, CJ104104

Consensus CDS

CCDS48406.1

UniProtKB/TrEMBL

Q8C134

Related

ENSMUSP00000027886.8, ENSMUST00000027886.14

Conserved Domains (2) summary

smart00147
Location:45 → 286

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd13310
Location:440 → 555

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
NM_001159968.1 → NP_001153440.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform c

See identical proteins and their annotated locations for NP_001153440.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC138109, AK036803, CJ104104

Consensus CDS

CCDS48405.1

UniProtKB/TrEMBL

Q8C134

Related

ENSMUSP00000132533.2, ENSMUST00000172057.8

Conserved Domains (3) summary

smart00147
Location:21 → 251

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd13310
Location:431 → 546

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

pfam00169
Location:430 → 540

PH; PH domain
NM_001357391.1 → NP_001344320.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus compared to isoform a.

Source sequence(s)

AC138109

Conserved Domains (2) summary

cd13310
Location:300 → 415

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

cl02485
Location:1 → 146

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_001357392.1 → NP_001344321.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus compared to isoform a.

Source sequence(s)

AC138109

Conserved Domains (2) summary

cd13310
Location:300 → 415

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

cl02485
Location:1 → 146

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
NM_023884.4 → NP_076373.3 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform a

See identical proteins and their annotated locations for NP_076373.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.

Source sequence(s)

AC138109, AK019543, AK033549, CJ104104

Consensus CDS

CCDS15396.1

UniProtKB/Swiss-Prot

Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6

UniProtKB/TrEMBL

Q8C134

Related

ENSMUSP00000139645.2, ENSMUST00000191605.7

Conserved Domains (2) summary

smart00147
Location:45 → 286

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd13310
Location:466 → 581

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

156631736..156767422 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243663.2 → XP_030099523.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

Conserved Domains (2) summary

cd13310
Location:326 → 441

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

cl02485
Location:1 → 146

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
XM_006497033.2 → XP_006497096.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

Conserved Domains (2) summary

cd13310
Location:326 → 441

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

cl02485
Location:1 → 146

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
XM_030243662.1 → XP_030099522.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

Conserved Domains (2) summary

cd13310
Location:326 → 441

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

cl02485
Location:1 → 146

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
XM_030243657.1 → XP_030099517.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

UniProtKB/TrEMBL

Q8C134

Conserved Domains (2) summary

smart00147
Location:45 → 286

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd13310
Location:440 → 555

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
XM_030243660.1 → XP_030099520.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

UniProtKB/TrEMBL

Q8C134

Conserved Domains (2) summary

smart00147
Location:45 → 286

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd13310
Location:440 → 555

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
XM_030243669.1 → XP_030099529.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X4

Conserved Domains (2) summary

cd13310
Location:300 → 415

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

cl02485
Location:1 → 146

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
XM_030243656.2 → XP_030099516.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

UniProtKB/TrEMBL

Q8C134

Conserved Domains (2) summary

smart00147
Location:45 → 286

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd13310
Location:440 → 555

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
XM_030243664.2 → XP_030099524.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

Conserved Domains (2) summary

cd13310
Location:326 → 441

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

cl02485
Location:1 → 146

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
XM_030243667.1 → XP_030099527.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X4

Conserved Domains (2) summary

cd13310
Location:300 → 415

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

cl02485
Location:1 → 146

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
XM_036154413.1 → XP_036010306.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X5

Conserved Domains (2) summary

cd13310
Location:235 → 350

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

cl02485
Location:1 → 55

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
XM_006497029.4 → XP_006497092.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

See identical proteins and their annotated locations for XP_006497092.1

UniProtKB/Swiss-Prot

Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6

UniProtKB/TrEMBL

Q8C134

Conserved Domains (2) summary

smart00147
Location:45 → 286

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd13310
Location:466 → 581

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
XM_006497028.5 → XP_006497091.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

See identical proteins and their annotated locations for XP_006497091.1

UniProtKB/Swiss-Prot

Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6

UniProtKB/TrEMBL

Q8C134

Related

ENSMUSP00000140342.2, ENSMUST00000188656.7

Conserved Domains (2) summary

smart00147
Location:45 → 286

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd13310
Location:466 → 581

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
XM_006497032.5 → XP_006497095.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

See identical proteins and their annotated locations for XP_006497095.1

UniProtKB/Swiss-Prot

Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6

UniProtKB/TrEMBL

Q8C134

Conserved Domains (2) summary

smart00147
Location:45 → 286

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd13310
Location:466 → 581

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
XM_006497030.4 → XP_006497093.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

See identical proteins and their annotated locations for XP_006497093.1

UniProtKB/Swiss-Prot

Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6

UniProtKB/TrEMBL

Q8C134

Related

ENSMUSP00000139618.2, ENSMUST00000185198.7

Conserved Domains (2) summary

smart00147
Location:45 → 286

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd13310
Location:466 → 581

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
XM_006497031.5 → XP_006497094.1 ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

See identical proteins and their annotated locations for XP_006497094.1

UniProtKB/Swiss-Prot

Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6

UniProtKB/TrEMBL

Q8C134

Conserved Domains (2) summary

smart00147
Location:45 → 286

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd13310
Location:466 → 581

PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain