Ido1 indoleamine 2,3-dioxygenase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ido1provided by MGI
Official Full Name: indoleamine 2,3-dioxygenase 1provided by MGI
Primary source: MGI:MGI:96416
See related: Ensembl:ENSMUSG00000031551 AllianceGenome:MGI:96416
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ido; Indo
Summary: Enables tryptophan 2,3-dioxygenase activity. Involved in quinolinate biosynthetic process. Acts upstream of or within several processes, including carboxylic acid metabolic process; regulation of apoptotic process; and regulation of cytokine production. Located in smooth muscle contractile fiber and stereocilium bundle. Is expressed in cerebral cortex; corpus striatum; embryo; extraembryonic component; and hippocampus. Used to study pre-eclampsia. Orthologous to human IDO1 (indoleamine 2,3-dioxygenase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in genital fat pad adult (RPKM 37.1), mammary gland adult (RPKM 7.7) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 12.76 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (25074148..25086987, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (24584133..24596952, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of E2 on the IDO1-mediated metabolic KYN pathway in OVX female mice.
Title: Effects of E2 on the IDO1-mediated metabolic KYN pathway in OVX female mice.
Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma gondii infection.
Title: Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma gondii infection.
Indoleamine 2, 3-dioxygenase 1 activation in macrophage exacerbates hepatic ischemia-reperfusion injury by triggering hepatocyte ferroptosis.
Title: Indoleamine 2, 3-dioxygenase 1 activation in macrophage exacerbates hepatic ischemia-reperfusion injury by triggering hepatocyte ferroptosis.
Indoleamine 2,3-dioxygenase 1-mediated iron metabolism in macrophages contributes to lipid deposition in nonalcoholic steatohepatitis.
Title: Indoleamine 2,3-dioxygenase 1-mediated iron metabolism in macrophages contributes to lipid deposition in nonalcoholic steatohepatitis.
Retention of stress susceptibility in the mdx mouse model of Duchenne muscular dystrophy after PGC-1alpha overexpression or ablation of IDO1 or CD38.
Title: Retention of stress susceptibility in the mdx mouse model of Duchenne muscular dystrophy after PGC-1α overexpression or ablation of IDO1 or CD38.
Upregulation of IDO gene expression reduces the immunogenicity of epidermal cells and strengthens the immune protection of epidermal cells during transplantation treatment of wounds.
Title: Upregulation of IDO gene expression reduces the immunogenicity of epidermal cells and strengthens the immune protection of epidermal cells during transplantation treatment of wounds.
Interactions of Indoleamine 2,3-dioxygenase-expressing LAMP3[+] dendritic cells with CD4[+] regulatory T cells and CD8[+] exhausted T cells: synergistically remodeling of the immunosuppressive microenvironment in cervical cancer and therapeutic implications.
Title: Interactions of Indoleamine 2,3-dioxygenase-expressing LAMP3(+) dendritic cells with CD4(+) regulatory T cells and CD8(+) exhausted T cells: synergistically remodeling of the immunosuppressive microenvironment in cervical cancer and therapeutic implications.
Indoleamine 2,3-Dioxygenase 1 Deletion-Mediated Kynurenine Insufficiency Inhibits Pathological Cardiac Hypertrophy.
Title: Indoleamine 2,3-Dioxygenase 1 Deletion-Mediated Kynurenine Insufficiency Inhibits Pathological Cardiac Hypertrophy.
IDO Regulates Macrophage Functions by Inhibiting the CCL2/CCR2 Signaling Pathway in Fungal Keratitis.
Title: IDO Regulates Macrophage Functions by Inhibiting the CCL2/CCR2 Signaling Pathway in Fungal Keratitis.
Dendritic cell-expressed IDO alleviates atherosclerosis by expanding CD4[+]CD25[+]Foxp3[+]Tregs through IDO-Kyn-AHR axis.
Title: Dendritic cell-expressed IDO alleviates atherosclerosis by expanding CD4(+)CD25(+)Foxp3(+)Tregs through IDO-Kyn-AHR axis.

Submit: New GeneRIF Correction See all GeneRIFs (209)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M69109 (e-PCR)
- UniSTS:179718

Ido (e-PCR), detects polymorphism
- UniSTS:143450

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amino acid binding	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables indoleamine 2,3-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables indoleamine 2,3-dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables indoleamine 2,3-dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxygen binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tryptophan 2,3-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tryptophan 2,3-dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytokine production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kynurenic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organismal response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell tolerance induction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of chronic inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of type 2 immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in quinolinate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tryptophan catabolic process to kynurenine	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tryptophan catabolic process to kynurenine	IDA Inferred from Direct Assay more info	PubMed
involved_in tryptophan catabolic process to kynurenine	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in smooth muscle contractile fiber	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium bundle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: indoleamine 2,3-dioxygenase 1

Names: IDO-1; indole 2,3-dioxygenase; indoleamine-pyrrole 2,3 dioxygenase

NP_001280619.1

EC 1.13.11.52

NP_032350.1

EC 1.13.11.52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293690.2 → NP_001280619.1 indoleamine 2,3-dioxygenase 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC114602

Consensus CDS

CCDS80866.1

UniProtKB/TrEMBL

D3YXV1

Related

ENSMUSP00000106295.2, ENSMUST00000110667.8

Conserved Domains (1) summary

pfam01231
Location:1 → 311

IDO; Indoleamine 2,3-dioxygenase
NM_008324.3 → NP_032350.1 indoleamine 2,3-dioxygenase 1 isoform 1

See identical proteins and their annotated locations for NP_032350.1

Status: VALIDATED

Source sequence(s)

AC114602

Consensus CDS

CCDS40299.1

UniProtKB/Swiss-Prot

P28776

Related

ENSMUSP00000033956.7, ENSMUST00000033956.7

Conserved Domains (1) summary

pfam01231
Location:16 → 402

IDO; Indoleamine 2,3-dioxygenase