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    Tpsg1 tryptase gamma 1 [ Mus musculus (house mouse) ]

    Gene ID: 26945, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tpsg1provided by MGI
    Official Full Name
    tryptase gamma 1provided by MGI
    Primary source
    MGI:MGI:1349391
    See related
    Ensembl:ENSMUSG00000033200 AllianceGenome:MGI:1349391
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmt; Prss31
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human TPSG1 (tryptase gamma 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 51.6), large intestine adult (RPKM 22.2) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tpsg1 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25588169..25593416)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25369195..25374442)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tryptase alpha/beta 1 Neighboring gene STARR-seq mESC enhancer starr_42106 Neighboring gene tryptase beta 2 Neighboring gene calcium channel, voltage-dependent, T type, alpha 1H subunit Neighboring gene predicted gene, 33617 Neighboring gene STARR-seq mESC enhancer starr_42107 Neighboring gene tektin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis. Hansbro PM, et al. J Biol Chem, 2014 Jun 27. PMID 24821729, Free PMC Article
    2. Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension. Wong GW, et al. J Biol Chem, 1999 Oct 22. PMID 10521469
    3. Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families. Caughey GH, et al. J Immunol, 2000 Jun 15. PMID 10843716
    4. Murine implantation serine proteinases 1 and 2: structure, function and evolution. Tang L, et al. Gene, 2005 Dec 30. PMID 16257142
    5. Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns. Wong GW, et al. J Biol Chem, 2004 Jan 23. PMID 14583634

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prss31-null mice had increased airway reactivity to methacholine but markedly reduced experimental chronic obstructive pulmonary disease and colitis.
      Title: Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tryptase gamma
    Names
    transmembrane tryptase
    NP_001344655.1
    NP_001398260.1
    NP_001398261.1
    NP_001398262.1
    NP_036164.2
    XP_006524421.1
    XP_006524423.1
    XP_006524426.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357726.1 → NP_001344655.1  tryptase gamma isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122454, AK027982
      Consensus CDS
      CCDS89021.1
      UniProtKB/TrEMBL
      E0CXD8, G3XA07
      Related
      ENSMUSP00000124008.2, ENSMUST00000160377.9
      Conserved Domains (1) summary
      cd00190
      Location:14 → 157
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_001411331.1 → NP_001398260.1  tryptase gamma isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122454
      UniProtKB/TrEMBL
      E0CXD8, G3XA07
      Related
      ENSMUSP00000124721.3, ENSMUST00000160485.9

    3. NM_001411332.1 → NP_001398261.1  tryptase gamma isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122454
      UniProtKB/TrEMBL
      E0CXD8, G3XA07
      Related
      ENSMUSP00000159911.1, ENSMUST00000249747.1

    4. NM_001411333.1 → NP_001398262.1  tryptase gamma isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122454
      UniProtKB/TrEMBL
      E9Q7E3
      Related
      ENSMUSP00000125180.2, ENSMUST00000162021.9

    5. NM_012034.4 → NP_036164.2  tryptase gamma isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122454
      Consensus CDS
      CCDS28518.1
      UniProtKB/Swiss-Prot
      Q9QUL7
      UniProtKB/TrEMBL
      D5L840, E9QLD4
      Related
      ENSMUSP00000024999.9, ENSMUST00000024999.16
      Conserved Domains (2) summary
      smart00020
      Location:29 → 257
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:30 → 260
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25588169..25593416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524358.3 → XP_006524421.1  tryptase gamma isoform X1

      UniProtKB/Swiss-Prot
      Q9QUL7
      UniProtKB/TrEMBL
      D5L840
      Conserved Domains (1) summary
      cd00190
      Location:87 → 317
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. XM_006524363.1 → XP_006524426.1  tryptase gamma isoform X2

      See identical proteins and their annotated locations for XP_006524426.1

      UniProtKB/TrEMBL
      E0CXD8, G3XA07
      Conserved Domains (1) summary
      cd00190
      Location:14 → 157
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. XM_006524360.1 → XP_006524423.1  tryptase gamma isoform X3

      UniProtKB/Swiss-Prot
      Q9QUL7
      UniProtKB/TrEMBL
      D5L840
      Conserved Domains (1) summary
      cd00190
      Location:41 → 271
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QUL7.1 GenPept UniProtKB/Swiss-Prot:Q9QUL7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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