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    Prkacb protein kinase, cAMP dependent, catalytic, beta [ Mus musculus (house mouse) ]

    Gene ID: 18749, updated on 27-Nov-2024

    Summary

    Official Symbol
    Prkacbprovided by MGI
    Official Full Name
    protein kinase, cAMP dependent, catalytic, betaprovided by MGI
    Primary source
    MGI:MGI:97594
    See related
    Ensembl:ENSMUSG00000005034 AllianceGenome:MGI:97594
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CbPKA; Pkacb; PKA C-beta
    Summary
    Enables ATP binding activity; cAMP-dependent protein kinase activity; and magnesium ion binding activity. Involved in protein phosphorylation. Acts upstream of or within negative regulation of smoothened signaling pathway; neural tube closure; and regulation of protein processing. Located in ciliary base. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver and biliary system; and nervous system. Orthologous to human PRKACB (protein kinase cAMP-activated catalytic subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 53.9), CNS E18 (RPKM 48.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Prkacb in Genome Data Viewer
    Location:
    3 H2; 3 72.28 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (146435334..146518691, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146729579..146812946, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 13 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:146349571-146349754 Neighboring gene predicted gene, 36521 Neighboring gene high mobility group box 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09230 Neighboring gene STARR-positive B cell enhancer ABC_E4605 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:146444299-146444452 Neighboring gene capping protein (actin filament) muscle Z-line, alpha 1 pseudogene Neighboring gene ribosomal protein L11 pseudogene Neighboring gene tubulin tyrosine ligase-like family, member 7 Neighboring gene STARR-seq mESC enhancer starr_09232 Neighboring gene STARR-positive B cell enhancer ABC_E6145

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cAMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cAMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of cAMP-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cAMP-dependent protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cAMP-dependent protein kinase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary base IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cAMP-dependent protein kinase catalytic subunit beta
    Names
    Cbeta2 PKA
    cAMP-dependent protein kinase C beta
    NP_001157670.1
    NP_001157671.1
    NP_001157672.1
    NP_001397387.1
    NP_001397388.1
    NP_001397389.1
    NP_035230.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164198.2NP_001157670.1  cAMP-dependent protein kinase catalytic subunit beta isoform 2

      See identical proteins and their annotated locations for NP_001157670.1

      Status: VALIDATED

      Source sequence(s)
      AC114618
      Consensus CDS
      CCDS51090.1
      UniProtKB/Swiss-Prot
      P68181
      Related
      ENSMUSP00000101743.2, ENSMUST00000106137.8
      Conserved Domains (1) summary
      cd14209
      Location:29318
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    2. NM_001164199.2NP_001157671.1  cAMP-dependent protein kinase catalytic subunit beta isoform 3

      See identical proteins and their annotated locations for NP_001157671.1

      Status: VALIDATED

      Source sequence(s)
      AC114618
      Consensus CDS
      CCDS51091.1
      UniProtKB/Swiss-Prot
      P68181
      Related
      ENSMUSP00000101744.2, ENSMUST00000106138.8
      Conserved Domains (1) summary
      cd14209
      Location:30319
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    3. NM_001164200.2NP_001157672.1  cAMP-dependent protein kinase catalytic subunit beta isoform 4

      See identical proteins and their annotated locations for NP_001157672.1

      Status: VALIDATED

      Source sequence(s)
      AC114618
      Consensus CDS
      CCDS51092.1
      UniProtKB/Swiss-Prot
      P68181
      Related
      ENSMUSP00000005164.8, ENSMUST00000005164.12
      Conserved Domains (2) summary
      PTZ00263
      Location:79398
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd14209
      Location:89378
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    4. NM_001410458.1NP_001397387.1  cAMP-dependent protein kinase catalytic subunit beta isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC114618
    5. NM_001410459.1NP_001397388.1  cAMP-dependent protein kinase catalytic subunit beta isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC114618, AC115889
    6. NM_001410460.1NP_001397389.1  cAMP-dependent protein kinase catalytic subunit beta isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC114618, AC115889
    7. NM_011100.5NP_035230.1  cAMP-dependent protein kinase catalytic subunit beta isoform 1

      See identical proteins and their annotated locations for NP_035230.1

      Status: VALIDATED

      Source sequence(s)
      AC114618, AC115889
      Consensus CDS
      CCDS17906.1
      UniProtKB/Swiss-Prot
      P68181, Q3TQH5, Q3UDD0, Q3UTH5
      Related
      ENSMUSP00000099573.4, ENSMUST00000102515.10
      Conserved Domains (1) summary
      cd14209
      Location:42331
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      146435334..146518691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)