Ly96 lymphocyte antigen 96 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ly96provided by MGI
Official Full Name: lymphocyte antigen 96provided by MGI
Primary source: MGI:MGI:1341909
See related: Ensembl:ENSMUSG00000025779 AllianceGenome:MGI:1341909
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MD2; MD-2; ESOP-1
Summary: Predicted to enable lipopolysaccharide immune receptor activity. Involved in cellular response to lipopolysaccharide; positive regulation of tumor necrosis factor production; and toll-like receptor 4 signaling pathway. Acts upstream of or within positive regulation of lipopolysaccharide-mediated signaling pathway. Part of lipopolysaccharide receptor complex. Is expressed in several structures, including extraembryonic component; gonad; immune system; integumental system; and nervous system. Orthologous to human LY96 (lymphocyte antigen 96). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 5.4), placenta adult (RPKM 3.9) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 A3; 1 5.1 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (16758680..16779829)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (16688456..16709605)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gut microbial metabolite hyodeoxycholic acid targets the TLR4/MD2 complex to attenuate inflammation and protect against sepsis.
Title: Gut microbial metabolite hyodeoxycholic acid targets the TLR4/MD2 complex to attenuate inflammation and protect against sepsis.
Heme induces inflammatory injury by directly binding to the complex of myeloid differentiation protein 2 and toll-like receptor 4.
Title: Heme induces inflammatory injury by directly binding to the complex of myeloid differentiation protein 2 and toll-like receptor 4.
HMGB1 augments cognitive impairment in sepsis-associated encephalopathy by binding to MD-2 and promoting NLRP3-induced neuroinflammation.
Title: HMGB1 augments cognitive impairment in sepsis-associated encephalopathy by binding to MD-2 and promoting NLRP3-induced neuroinflammation.
MD2 contributes to the pathogenesis of perioperative neurocognitive disorder via the regulation of alpha5GABAA receptors in aged mice.
Title: MD2 contributes to the pathogenesis of perioperative neurocognitive disorder via the regulation of α5GABA(A) receptors in aged mice.
Exercise-Induced Irisin Decreases Inflammation and Improves NAFLD by Competitive Binding with MD2.
Title: Exercise-Induced Irisin Decreases Inflammation and Improves NAFLD by Competitive Binding with MD2.
Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells.
Title: Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells.
Myeloid differentiation 2 deficiency attenuates AngII-induced arterial vascular oxidative stress, inflammation, and remodeling.
Title: Myeloid differentiation 2 deficiency attenuates AngII-induced arterial vascular oxidative stress, inflammation, and remodeling.
Myeloid differentiation protein 2 mediates angiotensin II-induced inflammation and mesenchymal transition in vascular endothelium.
Title: Myeloid differentiation protein 2 mediates angiotensin II-induced inflammation and mesenchymal transition in vascular endothelium.
1,7Bis(4hydroxy3methoxyphenyl)1,4,6heptatrien3one alleviates lipopolysaccharideinduced inflammation by targeting NFkappaB translocation in murine macrophages and it interacts with MD2 in silico.
Title: 1,7‑Bis(4‑hydroxy‑3‑methoxyphenyl)‑1,4,6‑heptatrien‑3‑one alleviates lipopolysaccharide‑induced inflammation by targeting NF‑κB translocation in murine macrophages and it interacts with MD2 in silico.
Macrophage-derived myeloid differentiation protein 2 plays an essential role in ox-LDL-induced inflammation and atherosclerosis.
Title: Macrophage-derived myeloid differentiation protein 2 plays an essential role in ox-LDL-induced inflammation and atherosclerosis.

Submit: New GeneRIF Correction See all GeneRIFs (68)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Toll-like receptor 4 binding	IEA Inferred from Electronic Annotation more info
enables lipopolysaccharide binding	IEA Inferred from Electronic Annotation more info
enables lipopolysaccharide immune receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipopolysaccharide immune receptor activity	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide immune receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in detection of lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of lipopolysaccharide-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of lipopolysaccharide-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipopolysaccharide-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of lipopolysaccharide-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of lipopolysaccharide-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 4 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor 4 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of lipopolysaccharide receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of lipopolysaccharide receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of lipopolysaccharide receptor complex	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lymphocyte antigen 96

Names: ly-96; myeloid differentiation factor-2; myeloid differentiation protein-2; protein MD-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159711.1 → NP_001153183.1 lymphocyte antigen 96 isoform B precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (B) has the same N- and C-termini but is shorter compared to isoform A.

Source sequence(s)

AB018550, AK019283, AY641431

Consensus CDS

CCDS78550.1

UniProtKB/TrEMBL

A0A087WQZ9, Q64HC9

Related

ENSMUSP00000140411.2, ENSMUST00000190366.2

Conserved Domains (1) summary

cl00274
Location:23 → 135

ML; The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...
NM_016923.2 → NP_058619.1 lymphocyte antigen 96 isoform A precursor

See identical proteins and their annotated locations for NP_058619.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).

Source sequence(s)

AB018550, AK019283

Consensus CDS

CCDS14832.1

UniProtKB/Swiss-Prot

Q9JHF9

UniProtKB/TrEMBL

Q14AM4, Q64HC9

Related

ENSMUSP00000026881.5, ENSMUST00000026881.11

Conserved Domains (1) summary

cl00274
Location:23 → 153

ML; The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...