Lhx8 LIM homeobox protein 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lhx8provided by MGI
Official Full Name: LIM homeobox protein 8provided by MGI
Primary source: MGI:MGI:1096343
See related: Ensembl:ENSMUSG00000096225 AllianceGenome:MGI:1096343
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: L3; Lhx7
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including female gonad development; forebrain neuron development; and odontogenesis of dentin-containing tooth. Located in female germ cell nucleus. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and respiratory system. Orthologous to human LHX8 (LIM homeobox 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in whole brain E14.5 (RPKM 4.0), CNS E14 (RPKM 3.2) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H4; 3 79.12 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (154011925..154036190, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (154306288..154330560, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings substantiate a major role for FIGLA, LHX8 and SOHLH1 as multifunctional regulators of networks necessary for oocyte maintenance and differentiation during early folliculogenesis.
Title: FIGLA, LHX8 and SOHLH1 transcription factor networks regulate mouse oocyte growth and differentiation.
Ablation of Lhx8 causes premature loss of germ cells by autophagy associated with impairment of DNA damage repair during meiosis.
Title: Lhx8 ablation leads to massive autophagy of mouse oocytes associated with DNA damage.
Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2
Title: Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2.
LHX8 can bind to the Lin28a promoter, and the depletion of Lin28a in Lhx8-deficient oocytes partially suppresses primordial oocyte activation.
Title: Lhx8 regulates primordial follicle activation and postnatal folliculogenesis.
Studies indicate that LIM homeobox proteins Lhx6 and -8 mRNAs are primarily expressed in the ventral telencephalon, specifically in the medial ganglionic eminence (MGE) of the basal forebrain and in subsets of neurons in the striatum.
Title: Lhx6 and Lhx8: cell fate regulators and beyond.
WNT/beta-catenin signaling is essential for the expression of Lhx8 in the maxillary arch cells.
Title: Identification of a face enhancer reveals direct regulation of LIM homeobox 8 (Lhx8) by wingless-int (WNT)/β-catenin signaling.
Lhx8 expression is related with the activation of primordial follicles, which is highly correlated with the demethylation of Lhx8-3' untranslated region and the high acetylation of histone H3.
Title: Expression and epigenetic dynamics of transcription regulator Lhx8 during mouse oogenesis.
The homeodomain protein LIM homeobox (Lhx)7 is essential for maintaining the morphological and molecular characteristics of cholinergic interneurons of the striatum.
Title: Transcription factor LIM homeobox 7 (Lhx7) maintains subtype identity of cholinergic interneurons in the mammalian striatum.
Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors.
Title: Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors.
the redundant activities of the LIM homeodomain proteins Lhx6 and Lhx7 are critical for craniofacial development and patterning of mammalian dentition
Title: The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491341

Lhx8 (e-PCR), detects polymorphism
- UniSTS:525713

PMC24762P1 (e-PCR)
- UniSTS:272273

Lhx8 (e-PCR), detects polymorphism
- UniSTS:507025

Lhx8 (e-PCR), detects polymorphism
- UniSTS:496539

BB371833 (e-PCR)
- UniSTS:207585

Lhx8 (e-PCR), detects polymorphism
- UniSTS:265724

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in forebrain neuron development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within forebrain neuron development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in female germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: LIM/homeobox protein Lhx8

Names: LIM homeo box protein 8; LIM homeobox protein 7; LIM/homeobox protein Lhx7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410060.1 → NP_001396989.1 LIM/homeobox protein Lhx8 isoform 2

Status: VALIDATED

Source sequence(s)

AC119163

Related

ENSMUSP00000145485.2, ENSMUST00000205251.3
NM_001410061.1 → NP_001396990.1 LIM/homeobox protein Lhx8 isoform 2

Status: VALIDATED

Source sequence(s)

AC119163
NM_001410062.1 → NP_001396991.1 LIM/homeobox protein Lhx8 isoform 3

Status: VALIDATED

Source sequence(s)

AC119163
NM_001410063.1 → NP_001396992.1 LIM/homeobox protein Lhx8 isoform 3

Status: VALIDATED

Source sequence(s)

AC119163
NM_010713.3 → NP_034843.2 LIM/homeobox protein Lhx8 isoform 1

See identical proteins and their annotated locations for NP_034843.2

Status: VALIDATED

Source sequence(s)

AC119163

Consensus CDS

CCDS17926.1

UniProtKB/Swiss-Prot

O35652, O70163, O88707, Q3TMT2

UniProtKB/TrEMBL

Q3TVH4

Related

ENSMUSP00000136047.2, ENSMUST00000177846.8

Conserved Domains (3) summary

cd09381
Location:95 → 150

LIM1_Lhx7_Lhx8; The first LIM domain of Lhx7 and Lhx8

cd09383
Location:157 → 211

LIM2_Lhx7_Lhx8; The second LIM domain of Lhx7 and Lhx8

pfam00046
Location:250 → 302

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

154011925..154036190 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501072.4 → XP_006501135.1 LIM/homeobox protein Lhx8 isoform X1

See identical proteins and their annotated locations for XP_006501135.1

UniProtKB/TrEMBL

H3BJ54

Conserved Domains (3) summary

cd09381
Location:64 → 119

LIM1_Lhx7_Lhx8; The first LIM domain of Lhx7 and Lhx8

cd09383
Location:126 → 180

LIM2_Lhx7_Lhx8; The second LIM domain of Lhx7 and Lhx8

pfam00046
Location:219 → 272

Homeobox; Homeobox domain