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    Crybb3 crystallin, beta B3 [ Mus musculus (house mouse) ]

    Gene ID: 12962, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Crybb3provided by MGI
    Official Full Name
    crystallin, beta B3provided by MGI
    Primary source
    MGI:MGI:102717
    See related
    Ensembl:ENSMUSG00000029352 AllianceGenome:MGI:102717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be a structural constituent of eye lens. Predicted to be involved in lens development in camera-type eye and visual perception. Is expressed in eye; gut; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in cataract 22 multiple types. Orthologous to human CRYBB3 (crystallin beta B3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in small intestine adult (RPKM 2.8), stomach adult (RPKM 2.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Crybb3 in Genome Data Viewer
    Location:
    5 F; 5 55.38 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113223705..113230102, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113075839..113082236, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22740 Neighboring gene predicted gene 43247 Neighboring gene crystallin, beta B2 Neighboring gene RIKEN cDNA 2900026A02 gene Neighboring gene RIKEN cDNA 4833439F03 gene Neighboring gene VISTA enhancer mm329 Neighboring gene predicted gene, 42161

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers. Limi S, et al. Invest Ophthalmol Vis Sci, 2019 Jan 2. PMID 30646012, Free PMC Article
    2. A Common Ancestral Mutation in CRYBB3 Identified in Multiple Consanguineous Families with Congenital Cataracts. Jiao X, et al. PLoS One, 2016. PMID 27326458, Free PMC Article
    3. The beta crystallin genes on human chromosome 22 define a new region of homology with mouse chromosome 5. Hulsebos TJ, et al. Genomics, 1995 Jan 20. PMID 7789995
    4. Aey2, a new mutation in the betaB2-crystallin-encoding gene of the mouse. Graw J, et al. Invest Ophthalmol Vis Sci, 2001 Jun. PMID 11381063
    5. Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice. Lovicu FJ, et al. Development, 1998 Sep. PMID 9693140

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of eye lens IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of eye lens IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of eye lens ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in eye development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    beta-crystallin B3
    Names
    beta-B3 crystallin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159650.1 → NP_001153122.1  beta-crystallin B3

      See identical proteins and their annotated locations for NP_001153122.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.
      Source sequence(s)
      BC058522, CJ046471
      Consensus CDS
      CCDS19547.1
      UniProtKB/Swiss-Prot
      Q9JJU9
      Related
      ENSMUSP00000113347.2, ENSMUST00000117143.8
      Conserved Domains (1) summary
      pfam00030
      Location:115 → 197
      Crystall; Beta/Gamma crystallin

    2. NM_001359004.1 → NP_001345933.1  beta-crystallin B3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. All eight variants encode the same protein.
      Source sequence(s)
      AC162528, CO428323
      Consensus CDS
      CCDS19547.1
      UniProtKB/Swiss-Prot
      Q9JJU9
      Related
      ENSMUSP00000112618.2, ENSMUST00000118226.8
      Conserved Domains (1) summary
      pfam00030
      Location:115 → 197
      Crystall; Beta/Gamma crystallin

    3. NM_001359005.1 → NP_001345934.1  beta-crystallin B3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.
      Source sequence(s)
      AC162528, CF739665
      Consensus CDS
      CCDS19547.1
      UniProtKB/Swiss-Prot
      Q9JJU9
      Related
      ENSMUSP00000112718.2, ENSMUST00000120506.8
      Conserved Domains (1) summary
      pfam00030
      Location:115 → 197
      Crystall; Beta/Gamma crystallin

    4. NM_001359006.1 → NP_001345935.1  beta-crystallin B3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.
      Source sequence(s)
      AC162528, CO428392
      Consensus CDS
      CCDS19547.1
      UniProtKB/Swiss-Prot
      Q9JJU9
      Conserved Domains (1) summary
      pfam00030
      Location:115 → 197
      Crystall; Beta/Gamma crystallin

    5. NM_001359007.1 → NP_001345936.1  beta-crystallin B3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.
      Source sequence(s)
      AC162528, CO428393
      Consensus CDS
      CCDS19547.1
      UniProtKB/Swiss-Prot
      Q9JJU9
      Conserved Domains (1) summary
      pfam00030
      Location:115 → 197
      Crystall; Beta/Gamma crystallin

    6. NM_001359008.1 → NP_001345937.1  beta-crystallin B3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.
      Source sequence(s)
      AC162528, CO046139
      Consensus CDS
      CCDS19547.1
      UniProtKB/Swiss-Prot
      Q9JJU9
      Conserved Domains (1) summary
      pfam00030
      Location:115 → 197
      Crystall; Beta/Gamma crystallin

    7. NM_021352.3 → NP_067327.1  beta-crystallin B3

      See identical proteins and their annotated locations for NP_067327.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.
      Source sequence(s)
      AJ272229, BC031442, CJ046471
      Consensus CDS
      CCDS19547.1
      UniProtKB/Swiss-Prot
      Q9JJU9
      Related
      ENSMUSP00000113572.2, ENSMUST00000119627.8
      Conserved Domains (1) summary
      pfam00030
      Location:115 → 197
      Crystall; Beta/Gamma crystallin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      113223705..113230102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254104.1 → XP_030109964.1  beta-crystallin B3 isoform X2

      UniProtKB/Swiss-Prot
      Q9JJU9
      Related
      ENSMUSP00000075440.7, ENSMUST00000076069.13
      Conserved Domains (1) summary
      pfam00030
      Location:115 → 197
      Crystall; Beta/Gamma crystallin

    2. XM_011249404.1 → XP_011247706.1  beta-crystallin B3 isoform X1

      Conserved Domains (1) summary
      pfam00030
      Location:127 → 209
      Crystall; Beta/Gamma crystallin

    RNA

    1. XR_004942434.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJU9.3 GenPept UniProtKB/Swiss-Prot:Q9JJU9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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