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    Zfp512b zinc finger protein 512B [ Mus musculus (house mouse) ]

    Gene ID: 269401, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp512bprovided by MGI
    Official Full Name
    zinc finger protein 512Bprovided by MGI
    Primary source
    MGI:MGI:2685478
    See related
    Ensembl:ENSMUSG00000000823 AllianceGenome:MGI:2685478
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm632; Znf512b
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of miRNA transcription. Predicted to be located in nucleoplasm. Is expressed in lung. Orthologous to human ZNF512B (zinc finger protein 512B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 26.1), testis adult (RPKM 23.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp512b in Genome Data Viewer
    Location:
    2 H4; 2 103.67 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181223925..181234572, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181582103..181592972, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 Neighboring gene STARR-positive B cell enhancer ABC_E3426 Neighboring gene uridine-cytidine kinase 1-like 1 Neighboring gene uridine-cytidine kinase 1-like 1, opposite strand Neighboring gene microRNA 7006 Neighboring gene STARR-positive B cell enhancer mm9_chr2:181335875-181336176 Neighboring gene sterile alpha motif domain containing 10 Neighboring gene pre-mRNA splicing factor 6 Neighboring gene STARR-seq mESC enhancer starr_06756

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 512B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164597.2 → NP_001158069.1  zinc finger protein 512B isoform 4

      See identical proteins and their annotated locations for NP_001158069.1

      Status: VALIDATED

      Source sequence(s)
      AL844529
      Consensus CDS
      CCDS50855.1
      UniProtKB/TrEMBL
      B7ZCR6, Q6ZPW1
      Related
      ENSMUSP00000104417.3, ENSMUST00000108789.9
      Conserved Domains (2) summary
      PRK12323
      Location:170 → 425
      PRK12323; DNA polymerase III subunit gamma/tau
      sd00017
      Location:573 → 594
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001409726.1 → NP_001396655.1  zinc finger protein 512B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL844529

    3. NM_001409728.1 → NP_001396657.1  zinc finger protein 512B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL844529

    4. NM_001409730.1 → NP_001396659.1  zinc finger protein 512B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL844529

    5. NM_001409731.1 → NP_001396660.1  zinc finger protein 512B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL844529
      Related
      ENSMUSP00000115601.2, ENSMUST00000128553.8

    6. NM_001409732.1 → NP_001396661.1  zinc finger protein 512B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL844529

    7. NM_001409733.1 → NP_001396662.1  zinc finger protein 512B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL844529
      UniProtKB/TrEMBL
      B7ZCR6

    8. NM_001409734.1 → NP_001396663.1  zinc finger protein 512B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL844529
      UniProtKB/TrEMBL
      B7ZCR6

    9. NM_001409735.1 → NP_001396664.1  zinc finger protein 512B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL844529

    10. NM_001409736.1 → NP_001396665.1  zinc finger protein 512B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL844529

    11. NM_001409737.1 → NP_001396666.1  zinc finger protein 512B isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL844529

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      181223925..181234572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500650.5 → XP_006500713.1  zinc finger protein 512B isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:141 → 517
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:530 → 559
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_011239943.4 → XP_011238245.1  zinc finger protein 512B isoform X2

      Conserved Domains (2) summary
      PHA03247
      Location:141 → 436
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:533 → 562
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. XR_375397.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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