Il36rn interleukin 36 receptor antagonist [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il36rnprovided by MGI
Official Full Name: interleukin 36 receptor antagonistprovided by MGI
Primary source: MGI:MGI:1859325
See related: Ensembl:ENSMUSG00000026983 AllianceGenome:MGI:1859325
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il1f5; If36rn; Il-1h3; Il1hy1; IL-36Ra; Fil1delta
Summary: Predicted to enable cytokine activity and interleukin-1 receptor binding activity. Acts upstream of or within negative regulation of interleukin-6 production. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in pustular psoriasis 14. Orthologous to human IL36RN (interleukin 36 receptor antagonist). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in stomach adult (RPKM 9.0) and lung adult (RPKM 1.0) See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 16.31 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (24166966..24172444)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (24276954..24282432)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cutaneous ischemia-reperfusion injury is exacerbated by IL-36 receptor antagonist deficiency.
Title: Cutaneous ischemia-reperfusion injury is exacerbated by IL-36 receptor antagonist deficiency.
Interleukin-36 receptor antagonist attenuates atherosclerosis development by inhibiting NLRP3 inflammasome.
Title: Interleukin-36 receptor antagonist attenuates atherosclerosis development by inhibiting NLRP3 inflammasome.
IL-36 receptor antagonist deficiency resulted in delayed wound healing due to excessive recruitment of immune cells.
Title: IL-36 receptor antagonist deficiency resulted in delayed wound healing due to excessive recruitment of immune cells.
these data reveal that IL-1Ra and IL-36Ra have opposing effects on the outcome of Pseudomonas aeruginosa keratitis
Title: Opposing Effects of IL-1Ra and IL-36Ra on Innate Immune Response to Pseudomonas aeruginosa Infection in C57BL/6 Mouse Corneas.
IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin
Title: IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin.
Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity
Title: Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity.
Transcripts for IL-1F5 are significantly increased in the involved skin of bi- and monotransgenic mice compared with their C57BL controls.
Title: IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression.
IL-1F5 mediates anti-inflammatory effects through its ability to induce interleukin-4 production, as a consequence of its interaction with orphan receptor single Ig IL-1R-related molecule (SIGIRR)/TIR8.
Title: IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8.
IL-1F5 has unique loop conformations for receptor binding specificity
Title: High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables interleukin-1 receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antifungal humoral response	IEA Inferred from Electronic Annotation more info
involved_in antifungal humoral response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-17 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-36 receptor antagonist protein

Names: IL-1 delta; IL-1F5; IL-1HY1; IL-1L1; interleukin 1 family, member 5 (delta); interleukin 1 receptor antagonist homolog 1; interleukin-1 HY1; interleukin-1 delta; interleukin-1 family member 5; interleukin-1 homolog 3; interleukin-1-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146087.2 → NP_001139559.1 interleukin-36 receptor antagonist protein

See identical proteins and their annotated locations for NP_001139559.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AL732430

Consensus CDS

CCDS50519.1

UniProtKB/Swiss-Prot

Q9JIG2, Q9QYY1

UniProtKB/TrEMBL

A2RTR0

Related

ENSMUSP00000028360.2, ENSMUST00000028360.8

Conserved Domains (1) summary

cl00094
Location:10 → 153

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
NM_001146088.2 → NP_001139560.1 interleukin-36 receptor antagonist protein

See identical proteins and their annotated locations for NP_001139560.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AL732430

Consensus CDS

CCDS50519.1

UniProtKB/Swiss-Prot

Q9JIG2, Q9QYY1

UniProtKB/TrEMBL

A2RTR0

Related

ENSMUSP00000126028.2, ENSMUST00000168941.8

Conserved Domains (1) summary

cl00094
Location:10 → 153

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
NM_019451.2 → NP_062324.2 interleukin-36 receptor antagonist protein

See identical proteins and their annotated locations for NP_062324.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AI413231, AK009741, CJ067640

Consensus CDS

CCDS50519.1

UniProtKB/Swiss-Prot

Q9JIG2, Q9QYY1

UniProtKB/TrEMBL

A2RTR0

Related

ENSMUSP00000110134.2, ENSMUST00000114490.7

Conserved Domains (1) summary

cl00094
Location:10 → 153

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).