Kctd11 potassium channel tetramerisation domain containing 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kctd11provided by MGI
Official Full Name: potassium channel tetramerisation domain containing 11provided by MGI
Primary source: MGI:MGI:2448712
See related: Ensembl:ENSMUSG00000046731 AllianceGenome:MGI:2448712
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ren
Summary: Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including negative regulation of neuroblast proliferation; negative regulation of smoothened signaling pathway; and positive regulation of neuron differentiation. Located in cytoplasm. Is expressed in several structures, including 1st branchial arch; central nervous system; ectoplacental cone; primitive streak; and sensory organ. Orthologous to human KCTD11 (potassium channel tetramerization domain containing 11). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.91 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69769090..69771811, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69878264..69880985, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of miR-337-3p in hypoxia/reoxygenation neuroblastoma cells increases KCTD11 expression.
Title: Downregulation of miR-337-3p in hypoxia/reoxygenation neuroblastoma cells increases KCTD11 expression.
SALL4 is a CRL3[REN/KCTD11] substrate that drives Sonic Hedgehog-dependent medulloblastoma.
Title: SALL4 is a CRL3(REN/KCTD11) substrate that drives Sonic Hedgehog-dependent medulloblastoma.
Results show negative regulation of HDAC1 by a Cul3-REN E3 ubiquitin ligase complex.
Title: Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation.
REN protein enhances caspase-3 activation and antagonizes the Shh pathway suggesting that this gene may represent a restraint of Shh signaling.
Title: Hedgehog antagonist REN(KCTD11) regulates proliferation and apoptosis of developing granule cell progenitors.
REN is upregulated by neurogenic signals (retinoic acid, EGF, and NGF) in embryonal stem (ES) cells and neural progenitor cell lines in association with neurotypic differentiation.
Title: REN: a novel, developmentally regulated gene that promotes neural cell differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

Kctd11 (e-PCR), detects polymorphism
- UniSTS:506685

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of neuroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nervous system development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuroblast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: BTB/POZ domain-containing protein KCTD11

Names: KCASH1 protein; RING-type E3 ubiquitin transferase KCTD11; RING-type E3 ubiquitin transferase subunit KCTD11; potassium channel tetramerization domain-containing protein 11; retinoic acid, EGF, and NGF upregulated

NP_694783.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.