Kank1 KN motif and ankyrin repeat domains 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kank1provided by MGI
Official Full Name: KN motif and ankyrin repeat domains 1provided by MGI
Primary source: MGI:MGI:2147707
See related: Ensembl:ENSMUSG00000032702 AllianceGenome:MGI:2147707
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ankrd15; mKIAA0172; A930031B09Rik; D330024H06Rik
Summary: Predicted to enable beta-catenin binding activity. Predicted to be involved in several processes, including negative regulation of cellular component organization; negative regulation of substrate adhesion-dependent cell spreading; and regulation of signal transduction. Predicted to be located in nucleus and ruffle membrane. Predicted to be active in cytoplasm and cytoskeleton. Is expressed in several structures, including central nervous system; craniocervical region bone; limb; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in spastic quadriplegic cerebral palsy 2. Orthologous to human KANK1 (KN motif and ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 22.5), ovary adult (RPKM 15.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 B; 19 20.33 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (25214146..25411861)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (25236732..25434498)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Protective Role of KANK1 in Podocyte Injury.
Title: The Protective Role of KANK1 in Podocyte Injury.
Loss of the KN Motif and AnKyrin Repeat Domain 1 (KANK1) Leads to Lymphoid Compartment Dysregulation in Murine Model.
Title: Loss of the KN Motif and AnKyrin Repeat Domain 1 (KANK1) Leads to Lymphoid Compartment Dysregulation in Murine Model.
Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.
Title: Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.
KANK1 binds to KIF21A through ankyrin repeat.
Title: Structural insights into ankyrin repeat-mediated recognition of the kinesin motor protein KIF21A by KANK1, a scaffold protein in focal adhesion.
Several key residues (i.e. Thr-1147, Leu-1152, Leu-1153, and Tyr-1154) at the C-terminal half of the KIF21A KBD peptide contact with the hydrophobic patch formed by Tyr-1176, Met-1209, Leu-1210, Leu-1213, and Leu-1248 from KANK1.
Title: Structural analyses of key features in the KANK1·KIF21A complex yield mechanistic insights into the cross-talk between microtubules and the cell cortex.
Data suggest that Kank negatively regulates the formation of actin stress fibers and cell migration through the inhibition of RhoA activity, which is controlled by binding of Kank to 14-3-3 in PI3K-Akt signaling.
Title: Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

General gene information

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Markers

D19Mit40 (e-PCR), detects polymorphism
- UniSTS:116495

RH124809 (e-PCR)
- UniSTS:161631

AU015049 (e-PCR)
- UniSTS:181216

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in podocyte cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment of cell polarity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: KN motif and ankyrin repeat domains 1; KN motif and ankyrin repeat domain-containing protein 1

Names: ankyrin repeat domain 15; ankyrin repeat domain-containing protein 15; kidney ankyrin repeat-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001348180.2 → NP_001335109.1 KN motif and ankyrin repeat domains 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AC126944, AC132319

UniProtKB/TrEMBL

Q6AXG6

Conserved Domains (4) summary

COG0666
Location:1080 → 1246

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:1160 → 1190

ANK; ANK repeat [structural motif]

pfam12075
Location:30 → 68

KN_motif; KN motif

pfam12796
Location:1164 → 1249

Ank_2; Ankyrin repeats (3 copies)
NM_001404570.1 → NP_001391499.1 KN motif and ankyrin repeat domains 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC126944, AC132319

UniProtKB/Swiss-Prot

E9Q238

UniProtKB/TrEMBL

Q6AXG6
NM_001404572.1 → NP_001391501.1 KN motif and ankyrin repeat domains 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC126944, AC132319

UniProtKB/Swiss-Prot

E9Q238

UniProtKB/TrEMBL

Q6AXG6
NM_001404573.1 → NP_001391502.1 KN motif and ankyrin repeat domains 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC126944, AC132319

UniProtKB/Swiss-Prot

E9Q238

UniProtKB/TrEMBL

Q6AXG6
NM_001404574.1 → NP_001391503.1 KN motif and ankyrin repeat domains 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC126944, AC132319

UniProtKB/TrEMBL

Q6AXG6
NM_001404575.1 → NP_001391504.1 KN motif and ankyrin repeat domains 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC126944, AC132319

UniProtKB/Swiss-Prot

E9Q238

UniProtKB/TrEMBL

Q6AXG6
NM_001404576.1 → NP_001391505.1 KN motif and ankyrin repeat domains 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC126944, AC132319

UniProtKB/Swiss-Prot

E9Q238

UniProtKB/TrEMBL

Q6AXG6
NM_001404577.1 → NP_001391506.1 KN motif and ankyrin repeat domains 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC126944, AC132319

UniProtKB/TrEMBL

Q6AXG6
NM_001404578.1 → NP_001391507.1 KN motif and ankyrin repeat domains 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC126944, AC132319

UniProtKB/TrEMBL

Q6AXG6
NM_001404579.1 → NP_001391508.1 KN motif and ankyrin repeat domains 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC126944, AC132319

UniProtKB/TrEMBL

Q6AXG6
NM_001404580.1 → NP_001391509.1 KN motif and ankyrin repeat domains 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC126944, AC132319

UniProtKB/TrEMBL

Q6AXG6
NM_001404581.1 → NP_001391510.1 KN motif and ankyrin repeat domains 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC126944

UniProtKB/TrEMBL

Q6AXG6
NM_001404582.1 → NP_001391511.1 KN motif and ankyrin repeat domains 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC126944

UniProtKB/TrEMBL

Q6AXG6
NM_001404583.1 → NP_001391512.1 KN motif and ankyrin repeat domains 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC126944

UniProtKB/TrEMBL

Q6AXG6
NM_001404584.1 → NP_001391513.1 KN motif and ankyrin repeat domains 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC126944

UniProtKB/TrEMBL

Q6AXG6
NM_001404585.1 → NP_001391514.1 KN motif and ankyrin repeat domains 1 isoform 8

Status: VALIDATED

Source sequence(s)

AC126944

UniProtKB/TrEMBL

Q6AXG6
NM_001404605.1 → NP_001391534.1 KN motif and ankyrin repeat domains 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC126944

UniProtKB/TrEMBL

Q6AXG6
NM_001404607.1 → NP_001391536.1 KN motif and ankyrin repeat domains 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC126944

UniProtKB/TrEMBL

Q6AXG6
NM_001404608.1 → NP_001391537.1 KN motif and ankyrin repeat domains 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC126944

UniProtKB/TrEMBL

Q6AXG6
NM_001404610.1 → NP_001391539.1 KN motif and ankyrin repeat domains 1 isoform 9

Status: VALIDATED

Source sequence(s)

AC126944

UniProtKB/TrEMBL

Q6AXG6
NM_181404.7 → NP_852069.4 KN motif and ankyrin repeat domains 1 isoform 1

See identical proteins and their annotated locations for NP_852069.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC126944, AC132319

Consensus CDS

CCDS37944.1

UniProtKB/Swiss-Prot

E9Q238

UniProtKB/TrEMBL

Q6AXG6

Related

ENSMUSP00000042177.9, ENSMUST00000049400.15

Conserved Domains (4) summary

COG0666
Location:1162 → 1328

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:1242 → 1272

ANK; ANK repeat [structural motif]

pfam12075
Location:30 → 68

KN_motif; KN motif

pfam12796
Location:1246 → 1331

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

25214146..25411861

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526585.3 → XP_006526648.1 KN motif and ankyrin repeat domain-containing protein 1 isoform X2

See identical proteins and their annotated locations for XP_006526648.1

UniProtKB/Swiss-Prot

E9Q238

UniProtKB/TrEMBL

Q6AXG6

Conserved Domains (4) summary

COG0666
Location:1162 → 1328

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:1242 → 1272

ANK; ANK repeat [structural motif]

pfam12075
Location:30 → 68

KN_motif; KN motif

pfam12796
Location:1246 → 1331

Ank_2; Ankyrin repeats (3 copies)
XM_036161387.1 → XP_036017280.1 KN motif and ankyrin repeat domain-containing protein 1 isoform X2

UniProtKB/Swiss-Prot

E9Q238

UniProtKB/TrEMBL

Q6AXG6

Conserved Domains (4) summary

COG0666
Location:1162 → 1328

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:1242 → 1272

ANK; ANK repeat [structural motif]

pfam12075
Location:30 → 68

KN_motif; KN motif

pfam12796
Location:1246 → 1331

Ank_2; Ankyrin repeats (3 copies)
XM_036161391.1 → XP_036017284.1 KN motif and ankyrin repeat domain-containing protein 1 isoform X4

UniProtKB/TrEMBL

Q6AXG6

Conserved Domains (4) summary

COG0666
Location:1080 → 1246

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:1160 → 1190

ANK; ANK repeat [structural motif]

pfam12075
Location:30 → 68

KN_motif; KN motif

pfam12796
Location:1164 → 1249

Ank_2; Ankyrin repeats (3 copies)
XM_030250693.2 → XP_030106553.1 KN motif and ankyrin repeat domain-containing protein 1 isoform X5

UniProtKB/TrEMBL

Q6AXG6

Conserved Domains (4) summary

COG0666
Location:1004 → 1170

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:1084 → 1114

ANK; ANK repeat [structural motif]

pfam00769
Location:102 → 330

ERM; Ezrin/radixin/moesin family

pfam12796
Location:1088 → 1173

Ank_2; Ankyrin repeats (3 copies)
XM_030250692.2 → XP_030106552.1 KN motif and ankyrin repeat domain-containing protein 1 isoform X5

UniProtKB/TrEMBL

Q6AXG6

Conserved Domains (4) summary

COG0666
Location:1004 → 1170

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:1084 → 1114

ANK; ANK repeat [structural motif]

pfam00769
Location:102 → 330

ERM; Ezrin/radixin/moesin family

pfam12796
Location:1088 → 1173

Ank_2; Ankyrin repeats (3 copies)
XM_006526590.3 → XP_006526653.1 KN motif and ankyrin repeat domain-containing protein 1 isoform X6

UniProtKB/TrEMBL

E9Q944

Related

ENSMUSP00000116660.2, ENSMUST00000146647.3

Conserved Domains (2) summary

pfam00769
Location:288 → 516

ERM; Ezrin/radixin/moesin family

pfam12075
Location:58 → 96

KN_motif; KN motif
XM_006526586.5 → XP_006526649.1 KN motif and ankyrin repeat domain-containing protein 1 isoform X3

UniProtKB/TrEMBL

Q6AXG6

Conserved Domains (5) summary

COG0666
Location:1108 → 1274

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:1188 → 1218

ANK; ANK repeat [structural motif]

pfam00769
Location:288 → 516

ERM; Ezrin/radixin/moesin family

pfam12075
Location:58 → 96

KN_motif; KN motif

pfam12796
Location:1192 → 1277

Ank_2; Ankyrin repeats (3 copies)