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    CRLF2 cytokine receptor like factor 2 [ Homo sapiens (human) ]

    Gene ID: 64109, updated on 9-Dec-2024

    Summary

    Official Symbol
    CRLF2provided by HGNC
    Official Full Name
    cytokine receptor like factor 2provided by HGNC
    Primary source
    HGNC:HGNC:14281
    See related
    Ensembl:ENSG00000205755 Ensembl:ENSG00000292363 MIM:300357; MIM:400023; AllianceGenome:HGNC:14281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRL2; TSLPR; CRLF2Y
    Summary
    This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CRLF2 in Genome Data Viewer
    Location:
    X;Y
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (1190490..1212649, complement)
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (1190490..1212649, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (1035684..1058464, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (1050430..1072677, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1314869..1331542, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1264869..1281542, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene repetin pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1252013-1252514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1252515-1253014 Neighboring gene 60S ribosomal protein L6-like Neighboring gene hESC enhancers GRCh37_chrX:1324089-1324592, GRCh37_chrY:1274255-1275102 and GRCh37_chrY:1273405-1274254 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chrX:1367406-1367922 and GRCh37_chrY:1317424-1317933 Neighboring gene NANOG hESC enhancer GRCh37_chrY:1330085-1330594 Neighboring gene colony stimulating factor 2 receptor subunit alpha Neighboring gene uncharacterized LOC124905238 Neighboring gene microRNA 3690 Neighboring gene RNA, 5S ribosomal pseudogene 498

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene repetin pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1252013-1252514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1252515-1253014 Neighboring gene 60S ribosomal protein L6-like Neighboring gene hESC enhancers GRCh37_chrX:1324089-1324592, GRCh37_chrY:1274255-1275102 and GRCh37_chrY:1273405-1274254 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chrX:1367406-1367922 and GRCh37_chrY:1317424-1317933 Neighboring gene NANOG hESC enhancer GRCh37_chrY:1330085-1330594 Neighboring gene colony stimulating factor 2 receptor subunit alpha Neighboring gene uncharacterized LOC124905238 Neighboring gene microRNA 3690 Neighboring gene RNA, 5S ribosomal pseudogene 498

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of cytokine receptor-like factor 2 (CRLF2) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables coreceptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytokine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cytokine receptor-like factor 2
    Names
    IL-XR
    TSLP receptor
    cytokine receptor CRL2 precusor
    thymic stromal lymphopoietin protein receptor
    thymic stromal-derived lymphopoietin receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034237.1 RefSeqGene

      Range
      5075..27234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001012288.3NP_001012288.2  cytokine receptor-like factor 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon which results in translation initiation at a downstream start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC188046, AF142570, AK026800, AY775789
      Consensus CDS
      CCDS75944.1
      UniProtKB/Swiss-Prot
      Q9HC73
      Related
      ENSP00000370979.4, ENSP00000518623.1, ENST00000381567.8, ENST00000711256.1
      Conserved Domains (1) summary
      cd00063
      Location:776
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. NM_022148.4NP_071431.2  cytokine receptor-like factor 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_071431.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC188046, AF142570, AK026800
      Consensus CDS
      CCDS75945.1
      UniProtKB/Swiss-Prot
      J3QKD1, Q5G7M1, Q9H5R3, Q9HC73
      UniProtKB/TrEMBL
      D0E2W4, Q53FI3
      Related
      ENSP00000383641.3, ENSP00000518625.1, ENST00000400841.8, ENST00000711254.1
      Conserved Domains (1) summary
      cd00063
      Location:119207
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RNA

    1. NR_110830.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon, lacks an alternate exon, and contains another alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC188046, AF142570, AK026800
      Related
      ENST00000467626.6, ENST00000711255.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      1190490..1212649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011546181.3XP_011544483.1  cytokine receptor-like factor 2 isoform X1

      See identical proteins and their annotated locations for XP_011544483.1

      UniProtKB/TrEMBL
      Q53FI3
      Conserved Domains (1) summary
      cd00063
      Location:118206
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      1190490..1212649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545634.3XP_011543936.1  cytokine receptor-like factor 2 isoform X1

      See identical proteins and their annotated locations for XP_011543936.1

      UniProtKB/TrEMBL
      Q53FI3
      Conserved Domains (1) summary
      cd00063
      Location:118206
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      1035684..1058464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327570.1XP_054183545.1  cytokine receptor-like factor 2 isoform X1

      UniProtKB/TrEMBL
      Q53FI3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      1050430..1072677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328319.1XP_054184294.1  cytokine receptor-like factor 2 isoform X1

      UniProtKB/TrEMBL
      Q53FI3