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    NCOA7 nuclear receptor coactivator 7 [ Homo sapiens (human) ]

    Gene ID: 135112, updated on 10-Dec-2024

    Summary

    Official Symbol
    NCOA7provided by HGNC
    Official Full Name
    nuclear receptor coactivator 7provided by HGNC
    Primary source
    HGNC:HGNC:21081
    See related
    Ensembl:ENSG00000111912 MIM:609752; AllianceGenome:HGNC:21081
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESNA1; TLDC4; ERAP140; NCOA7-AS; Nbla00052; Nbla10993; dJ187J11.3
    Summary
    Enables nuclear receptor binding activity and nuclear receptor coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 17.8), adrenal (RPKM 16.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NCOA7 in Genome Data Viewer
    Location:
    6q22.31-q22.32
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (125781115..125932034)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (126969790..127120723)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (126102261..126253180)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17519 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:126091955-126092877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17520 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:126101539-126102088 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:126102089-126102637 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17521 Neighboring gene H3K27ac hESC enhancers GRCh37_chr6:126111392-126111892 and GRCh37_chr6:126111893-126112393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25031 Neighboring gene tRNA-Glu (anticodon CTC) 1-7 Neighboring gene hes related family bHLH transcription factor with YRPW motif 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:126139229-126139730 Neighboring gene NCOA7 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 14390 Neighboring gene RN7SK pseudogene 56 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17523 Neighboring gene uncharacterized LOC124901397 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:126239365-126240564 Neighboring gene NCOA7-HINT3 intergenic CAGE-defined high expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25033 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:126306909-126307739 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:126307740-126308569 Neighboring gene RNA, 5S ribosomal pseudogene 216 Neighboring gene histidine triad nucleotide binding protein 3 Neighboring gene tRNA methyltransferase 11 homolog Neighboring gene Sharpr-MPRA regulatory region 12057 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ45605, MGC88425

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nuclear receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear receptor coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    nuclear receptor coactivator 7
    Names
    140 kDa estrogen receptor-associated protein
    TBC/LysM-associated domain containing 4
    estrogen nuclear receptor coactivator 1
    estrogen receptor associated protein 140 kDa
    putative protein product of Nbla00052
    putative protein product of Nbla10993

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122842.3NP_001116314.1  nuclear receptor coactivator 7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK127512, AK294558, AL035689, AL834442, BX537385, DA770225
      UniProtKB/TrEMBL
      B3KXK4
      Conserved Domains (2) summary
      smart00584
      Location:769931
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:122158
      LysM; LysM domain
    2. NM_001199619.2NP_001186548.1  nuclear receptor coactivator 7 isoform 1

      See identical proteins and their annotated locations for NP_001186548.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' UTR, compared to variant 1. Variants 1, 3 and 4 encode the same longest isoform (1).
      Source sequence(s)
      AF493978, AL035689, AL078594, AL834442, BC137094, BX537385
      Consensus CDS
      CCDS5132.1
      UniProtKB/Swiss-Prot
      B2RNS2, B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4, Q8NI08
      UniProtKB/TrEMBL
      B3KXK4
      Related
      ENSP00000357341.3, ENST00000368357.7
      Conserved Domains (2) summary
      smart00584
      Location:780942
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:122158
      LysM; LysM domain
    3. NM_001199620.2NP_001186549.1  nuclear receptor coactivator 7 isoform 1

      See identical proteins and their annotated locations for NP_001186549.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate 5' UTR, compared to variant 1. Variants 1, 3 and 4 encode the same longest isoform (1).
      Source sequence(s)
      AF493978, AK294558, AL035689, AL078594, AL834442, BC137094, BX537385
      Consensus CDS
      CCDS5132.1
      UniProtKB/Swiss-Prot
      B2RNS2, B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4, Q8NI08
      UniProtKB/TrEMBL
      B3KXK4
      Conserved Domains (2) summary
      smart00584
      Location:780942
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:122158
      LysM; LysM domain
    4. NM_001199621.2NP_001186550.1  nuclear receptor coactivator 7 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an internal exon, resulting in a downstream in-frame AUG start codon, and uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK294558, AL035689, AL834442, BC137094, BX537385, DA770225
      Consensus CDS
      CCDS56448.1
      UniProtKB/TrEMBL
      Q8N3C8
      Related
      ENSP00000229634.9, ENST00000229634.13
      Conserved Domains (2) summary
      smart00584
      Location:665827
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:1854
      LysM; LysM domain
    5. NM_001199622.2NP_001186551.1  nuclear receptor coactivator 7 isoform 4

      See identical proteins and their annotated locations for NP_001186551.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks multiple exons from the 5' end and has an alternate 5' exon, compared to variant 1. The resulting isoform (4) is much shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK094706, AL035689, AL834442, BX537385, DA992384
      Consensus CDS
      CCDS83125.1
      UniProtKB/TrEMBL
      A0A023IN41, H0Y5F6
      Related
      ENSP00000398268.2, ENST00000438495.6
      Conserved Domains (1) summary
      smart00584
      Location:57219
      TLDc; domain in TBC and LysM domain containing proteins
    6. NM_181782.5NP_861447.3  nuclear receptor coactivator 7 isoform 1

      See identical proteins and their annotated locations for NP_861447.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variants 3 and 4 encode the same longest isoform (1).
      Source sequence(s)
      AK294558, AL035689, AL834442, BC137094, BX537385, DA770225
      Consensus CDS
      CCDS5132.1
      UniProtKB/Swiss-Prot
      B2RNS2, B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4, Q8NI08
      UniProtKB/TrEMBL
      B3KXK4
      Related
      ENSP00000376269.2, ENST00000392477.7
      Conserved Domains (2) summary
      smart00584
      Location:780942
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:122158
      LysM; LysM domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      125781115..125932034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418206.1XP_047274162.1  nuclear receptor coactivator 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RNS2, B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4, Q8NI08
      UniProtKB/TrEMBL
      B3KXK4
    2. XM_047418207.1XP_047274163.1  nuclear receptor coactivator 7 isoform X2

      UniProtKB/TrEMBL
      B3KXK4
      Conserved Domains (2) summary
      smart00584
      Location:769931
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:122158
      LysM; LysM domain
    3. XM_024446332.2XP_024302100.1  nuclear receptor coactivator 7 isoform X2

      UniProtKB/TrEMBL
      B3KXK4
      Conserved Domains (2) summary
      smart00584
      Location:769931
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:122158
      LysM; LysM domain
    4. XM_017010270.2XP_016865759.1  nuclear receptor coactivator 7 isoform X2

      UniProtKB/TrEMBL
      B3KXK4
      Conserved Domains (2) summary
      smart00584
      Location:769931
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:122158
      LysM; LysM domain
    5. XM_006715340.5XP_006715403.1  nuclear receptor coactivator 7 isoform X1

      See identical proteins and their annotated locations for XP_006715403.1

      UniProtKB/Swiss-Prot
      B2RNS2, B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4, Q8NI08
      UniProtKB/TrEMBL
      B3KXK4
      Conserved Domains (2) summary
      smart00584
      Location:780942
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:122158
      LysM; LysM domain
    6. XM_017010274.3XP_016865763.1  nuclear receptor coactivator 7 isoform X2

      UniProtKB/TrEMBL
      B3KXK4
      Conserved Domains (2) summary
      smart00584
      Location:769931
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:122158
      LysM; LysM domain
    7. XM_005266822.5XP_005266879.1  nuclear receptor coactivator 7 isoform X1

      See identical proteins and their annotated locations for XP_005266879.1

      UniProtKB/Swiss-Prot
      B2RNS2, B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4, Q8NI08
      UniProtKB/TrEMBL
      B3KXK4
      Conserved Domains (2) summary
      smart00584
      Location:780942
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:122158
      LysM; LysM domain
    8. XM_017010273.3XP_016865762.1  nuclear receptor coactivator 7 isoform X2

      UniProtKB/TrEMBL
      B3KXK4
      Conserved Domains (2) summary
      smart00584
      Location:769931
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:122158
      LysM; LysM domain
    9. XM_024446331.2XP_024302099.1  nuclear receptor coactivator 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RNS2, B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4, Q8NI08
      UniProtKB/TrEMBL
      B3KXK4
      Conserved Domains (2) summary
      smart00584
      Location:780942
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:122158
      LysM; LysM domain
    10. XM_017010272.3XP_016865761.1  nuclear receptor coactivator 7 isoform X2

      UniProtKB/TrEMBL
      B3KXK4
      Conserved Domains (2) summary
      smart00584
      Location:769931
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:122158
      LysM; LysM domain
    11. XM_017010269.2XP_016865758.1  nuclear receptor coactivator 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RNS2, B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4, Q8NI08
      UniProtKB/TrEMBL
      B3KXK4
      Conserved Domains (2) summary
      smart00584
      Location:780942
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:122158
      LysM; LysM domain

    RNA

    1. XR_007059204.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      126969790..127120723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354274.1XP_054210249.1  nuclear receptor coactivator 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RNS2, B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4, Q8NI08
      UniProtKB/TrEMBL
      B3KXK4
    2. XM_054354277.1XP_054210252.1  nuclear receptor coactivator 7 isoform X2

      UniProtKB/TrEMBL
      B3KXK4
    3. XM_054354278.1XP_054210253.1  nuclear receptor coactivator 7 isoform X2

      UniProtKB/TrEMBL
      B3KXK4
    4. XM_054354275.1XP_054210250.1  nuclear receptor coactivator 7 isoform X2

      UniProtKB/TrEMBL
      B3KXK4
    5. XM_054354271.1XP_054210246.1  nuclear receptor coactivator 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RNS2, B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4, Q8NI08
      UniProtKB/TrEMBL
      B3KXK4
    6. XM_054354280.1XP_054210255.1  nuclear receptor coactivator 7 isoform X2

      UniProtKB/TrEMBL
      B3KXK4
    7. XM_054354272.1XP_054210247.1  nuclear receptor coactivator 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RNS2, B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4, Q8NI08
      UniProtKB/TrEMBL
      B3KXK4
    8. XM_054354279.1XP_054210254.1  nuclear receptor coactivator 7 isoform X2

      UniProtKB/TrEMBL
      B3KXK4
    9. XM_054354270.1XP_054210245.1  nuclear receptor coactivator 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RNS2, B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4, Q8NI08
      UniProtKB/TrEMBL
      B3KXK4
    10. XM_054354276.1XP_054210251.1  nuclear receptor coactivator 7 isoform X2

      UniProtKB/TrEMBL
      B3KXK4
    11. XM_054354273.1XP_054210248.1  nuclear receptor coactivator 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RNS2, B7Z2C4, B9EH71, G8JL91, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4, Q8NI08
      UniProtKB/TrEMBL
      B3KXK4

    RNA

    1. XR_008487257.1 RNA Sequence