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    APBB2 amyloid beta precursor protein binding family B member 2 [ Homo sapiens (human) ]

    Gene ID: 323, updated on 27-Nov-2024

    Summary

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    Official Symbol
    APBB2provided by HGNC
    Official Full Name
    amyloid beta precursor protein binding family B member 2provided by HGNC
    Primary source
    HGNC:HGNC:582
    See related
    Ensembl:ENSG00000163697 MIM:602710; AllianceGenome:HGNC:582
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FE65L; FE65L1
    Summary
    The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in fat (RPKM 13.0), thyroid (RPKM 11.7) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See APBB2 in Genome Data Viewer
    Location:
    4p14-p13
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (40810027..41214542, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (40783978..41188337, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (40812044..41216559, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 47 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:40517897-40518207 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:40527595-40528394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:40528395-40529195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15379 Neighboring gene microRNA 4802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:40563453-40563953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:40564097-40564607 Neighboring gene NANOG hESC enhancer GRCh37_chr4:40566953-40567529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21492 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:40583996-40584174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:40593988-40594488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:40597457-40597958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21493 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:40621147-40621674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15380 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15381 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:40630738-40631614 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:40631615-40632492 Neighboring gene NANOG hESC enhancer GRCh37_chr4:40663700-40664205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21495 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:40674299-40675498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21497 Neighboring gene NANOG hESC enhancer GRCh37_chr4:40700528-40701301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21501 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:40809683-40810183 Neighboring gene NOP2/Sun RNA methyltransferase family member 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:40837789-40838358 Neighboring gene NANOG hESC enhancer GRCh37_chr4:40842967-40843468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21503 Neighboring gene ARF like GTPase 4A pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15382 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:40899403-40899903 Neighboring gene Sharpr-MPRA regulatory region 7650 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15383 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:40968186-40969148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15384 Neighboring gene RNA, 5S ribosomal pseudogene 160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:41065688-41066188 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:41071796-41072346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21504 Neighboring gene RNA, U6 small nuclear 836, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:41126569-41127768 Neighboring gene RNA, U6 small nuclear 1195, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21505 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15387 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:41218499-41219313 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:41244640-41244866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:41259655-41260155 Neighboring gene UCHL1 divergent transcript Neighboring gene ubiquitin C-terminal hydrolase L1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. APBB2 is associated with amphetamine use and plasma beta-amyloids in patients receiving methadone maintenance treatment. Liu CC, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2018 Apr 20. PMID 29330135
    2. Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry. Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, et al. JAMA, 2019 Nov 5. PMID 31688885, Free PMC Article
    3. Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells. Porayette P, et al. J Biol Chem, 2009 Aug 28. PMID 19542221, Free PMC Article
    4. Analysis of APBB2 gene polymorphisms in sporadic Alzheimer's disease. Golanska E, et al. Neurosci Lett, 2008 Dec 12. PMID 18852029
    5. GSK3β Interactions with Amyloid Genes: An Autopsy Verification and Extension. Hohman TJ, et al. Neurotox Res, 2015 Oct. PMID 26194614, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR2053p promotes lung cancer progression by targeting APBB2.
      Title: miR‑205‑3p promotes lung cancer progression by targeting APBB2.
    2. Hsa-miR-30a-3p attenuates gastric adenocarcinoma proliferation and metastasis via APBB2.
      Title: Hsa-miR-30a-3p attenuates gastric adenocarcinoma proliferation and metastasis via APBB2.
    3. In this genome-wide association study, variants at the APBB2 locus demonstrated differential association with primary open-angle glaucoma by ancestry.
      Title: Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.
    4. Genetic variants in the APBB2 gene were associated with use of amphetamine in opioid dependent patients under methadone maintenance treatment. The haplotype combinations further confirmed this observation, especially in the patients with a positive urine morphine test result. The major genotype and allele type carriers showed a two-time higher risk of amphetamine use than the minor allele type carriers.
      Title: APBB2 is associated with amphetamine use and plasma beta-amyloids in patients receiving methadone maintenance treatment.
    5. APBB2 was differentially expressed between Fibromyalgia patients and healthy controls.
      Title: Genome-wide expression profiling in the peripheral blood of patients with fibromyalgia.
    6. results provide additional evidence of a genetic interaction between GSK3beta and APBB2 and further suggest that GSK3beta is involved in the pathophysiology of both of the primary neuropathologies of Alzheimer's disease
      Title: GSK3β Interactions with Amyloid Genes: An Autopsy Verification and Extension.
    7. The APBB2 rs13133980 G allele was over-represented in centenarians with severe cognitive impairment compared to individuals without this disability.
      Title: APBB2 genetic polymorphisms are associated with severe cognitive impairment in centenarians.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
    9. The differential processing of amyloid-beta precursor via secretase enzymes regulates the proliferation and differentiation of human embryonic stem cell.
      Title: Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells.
    10. The hCV1558625 G allele was over-represented in patients with onset under age 70 compared to controls in the same age range.
      Title: Analysis of APBB2 gene polymorphisms in sporadic Alzheimer's disease.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association scan of dental caries in the permanent dentition.
    EBI GWAS Catalog
    Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC35575, DKFZp434E033

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in maintenance of lens transparency ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell cycle phase transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuron migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synapse organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    amyloid beta precursor protein binding family B member 2
    Names
    Fe65-like 1
    protein Fe65-like 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013337.1 RefSeqGene

      Range
      5077..409592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001166050.2 → NP_001159522.1  amyloid beta precursor protein binding family B member 2 isoform b

      See identical proteins and their annotated locations for NP_001159522.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.
      Source sequence(s)
      AC131953, AK295974, AK304247, AL080130, BC027946, DB236935
      Consensus CDS
      CCDS54761.1
      UniProtKB/Swiss-Prot
      B4DSL4, E9PG87, Q8IUI6, Q92870
      UniProtKB/TrEMBL
      B4E2F2
      Related
      ENSP00000295974.8, ENST00000295974.12
      Conserved Domains (3) summary
      cd01271
      Location:582 → 708
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:416 → 553
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    2. NM_001166051.2 → NP_001159523.1  amyloid beta precursor protein binding family B member 2 isoform d

      See identical proteins and their annotated locations for NP_001159523.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the presence and absence of exons in the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (d) is significantly shorter at the N-terminus, compared to isoform a. Variants 4, 5, 6 and 7 encode the same isoform.
      Source sequence(s)
      AC131953, AL080130, BU184203, BX440903, DC400218
      Consensus CDS
      CCDS54760.1
      UniProtKB/Swiss-Prot
      Q92870
      Related
      ENSP00000423765.1, ENST00000504305.5
      Conserved Domains (1) summary
      cd01271
      Location:34 → 160
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

    3. NM_001166052.2 → NP_001159524.1  amyloid beta precursor protein binding family B member 2 isoform d

      See identical proteins and their annotated locations for NP_001159524.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the presence and absence of exons in the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (d) is significantly shorter at the N-terminus, compared to isoform a. Variants 4, 5, 6 and 7 encode the same isoform.
      Source sequence(s)
      AC131953, AK299800, AL080130, DC400218
      Consensus CDS
      CCDS54760.1
      UniProtKB/Swiss-Prot
      Q92870
      Related
      ENSP00000425802.1, ENST00000502841.5
      Conserved Domains (1) summary
      cd01271
      Location:34 → 160
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

    4. NM_001166053.1 → NP_001159525.1  amyloid beta precursor protein binding family B member 2 isoform d

      See identical proteins and their annotated locations for NP_001159525.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the presence and absence of exons in the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (d) is significantly shorter at the N-terminus, compared to isoform a. Variants 4, 5, 6 and 7 encode the same isoform.
      Source sequence(s)
      AC131953, AL080130, CX782504, DC372060, DC377693
      Consensus CDS
      CCDS54760.1
      UniProtKB/Swiss-Prot
      Q92870
      Conserved Domains (1) summary
      cd01271
      Location:34 → 160
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

    5. NM_001166054.1 → NP_001159526.1  amyloid beta precursor protein binding family B member 2 isoform d

      See identical proteins and their annotated locations for NP_001159526.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the presence and absence of exons in the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (d) is significantly shorter at the N-terminus, compared to isoform a. Variants 4, 5, 6 and 7 encode the same isoform.
      Source sequence(s)
      AC131953, AL080130, CX782504, DC372060, DC377357
      Consensus CDS
      CCDS54760.1
      UniProtKB/Swiss-Prot
      Q92870
      Conserved Domains (1) summary
      cd01271
      Location:34 → 160
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

    6. NM_001330656.2 → NP_001317585.1  amyloid beta precursor protein binding family B member 2 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (e) that is shorter than isoform a. Variants 8 and 9 encode the same isoform.
      Source sequence(s)
      AC093804, AC131953, AL080130, BC027946, BC088372, DB078521, DB236935
      Consensus CDS
      CCDS82918.1
      UniProtKB/TrEMBL
      G5E9Y1, H0YAJ5
      Related
      ENSP00000421539.1, ENST00000506352.5
      Conserved Domains (3) summary
      cd01271
      Location:561 → 687
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395 → 532
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    7. NM_001330658.2 → NP_001317587.1  amyloid beta precursor protein binding family B member 2 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an exon in the 5' UTR, uses an alternate in-frame splice site and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (e) that is shorter than isoform a. Variants 8 and 9 encode the same isoform.
      Source sequence(s)
      AC093804, AC131953, AL080130, AL596608, BC027946, BC088372
      Consensus CDS
      CCDS82918.1
      UniProtKB/TrEMBL
      G5E9Y1, H0YAJ5
      Conserved Domains (3) summary
      cd01271
      Location:561 → 687
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395 → 532
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    8. NM_004307.2 → NP_004298.1  amyloid beta precursor protein binding family B member 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC131953, AK226179, AK295974, AL080130, DB236935
      Consensus CDS
      CCDS54762.1
      UniProtKB/TrEMBL
      B4E2F2
      Related
      ENSP00000427211.1, ENST00000508593.6
      Conserved Domains (3) summary
      cd01271
      Location:583 → 709
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417 → 554
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    9. NM_173075.5 → NP_775098.2  amyloid beta precursor protein binding family B member 2 isoform c

      See identical proteins and their annotated locations for NP_775098.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses two alternate in-frame splice sites and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
      Source sequence(s)
      AC093804, AC131953, AL080130, BC027946, DB236935
      Consensus CDS
      CCDS43224.1
      UniProtKB/TrEMBL
      H0YAJ5
      Related
      ENSP00000426018.1, ENST00000513140.5
      Conserved Domains (3) summary
      cd01271
      Location:560 → 686
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395 → 532
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      40810027..41214542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047450191.1 → XP_047306147.1  amyloid beta precursor protein binding family B member 2 isoform X9

      UniProtKB/TrEMBL
      G5E9Y1

    2. XM_047450181.1 → XP_047306137.1  amyloid beta precursor protein binding family B member 2 isoform X4

      UniProtKB/Swiss-Prot
      B4DSL4, E9PG87, Q8IUI6, Q92870

    3. XM_047450169.1 → XP_047306125.1  amyloid beta precursor protein binding family B member 2 isoform X2

    4. XM_047450187.1 → XP_047306143.1  amyloid beta precursor protein binding family B member 2 isoform X8

    5. XM_047450175.1 → XP_047306131.1  amyloid beta precursor protein binding family B member 2 isoform X3

    6. XM_047450164.1 → XP_047306120.1  amyloid beta precursor protein binding family B member 2 isoform X1

    7. XM_047450190.1 → XP_047306146.1  amyloid beta precursor protein binding family B member 2 isoform X9

      UniProtKB/TrEMBL
      G5E9Y1

    8. XM_047450184.1 → XP_047306140.1  amyloid beta precursor protein binding family B member 2 isoform X7

    9. XM_047450180.1 → XP_047306136.1  amyloid beta precursor protein binding family B member 2 isoform X4

      UniProtKB/Swiss-Prot
      B4DSL4, E9PG87, Q8IUI6, Q92870

    10. XM_047450166.1 → XP_047306122.1  amyloid beta precursor protein binding family B member 2 isoform X2

    11. XM_047450186.1 → XP_047306142.1  amyloid beta precursor protein binding family B member 2 isoform X8

    12. XM_047450173.1 → XP_047306129.1  amyloid beta precursor protein binding family B member 2 isoform X3

    13. XM_047450161.1 → XP_047306117.1  amyloid beta precursor protein binding family B member 2 isoform X1

    14. XM_047450183.1 → XP_047306139.1  amyloid beta precursor protein binding family B member 2 isoform X7

    15. XM_047450179.1 → XP_047306135.1  amyloid beta precursor protein binding family B member 2 isoform X4

      UniProtKB/Swiss-Prot
      B4DSL4, E9PG87, Q8IUI6, Q92870

    16. XM_047450170.1 → XP_047306126.1  amyloid beta precursor protein binding family B member 2 isoform X2

    17. XM_047450172.1 → XP_047306128.1  amyloid beta precursor protein binding family B member 2 isoform X3

    18. XM_047450159.1 → XP_047306115.1  amyloid beta precursor protein binding family B member 2 isoform X1

    19. XM_017008148.3 → XP_016863637.1  amyloid beta precursor protein binding family B member 2 isoform X5

      UniProtKB/TrEMBL
      B4E2F2

    20. XM_017008152.3 → XP_016863641.1  amyloid beta precursor protein binding family B member 2 isoform X7

      UniProtKB/TrEMBL
      H0YAJ5
      Conserved Domains (3) summary
      cd01271
      Location:563 → 689
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395 → 534
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    21. XM_047450178.1 → XP_047306134.1  amyloid beta precursor protein binding family B member 2 isoform X4

      UniProtKB/Swiss-Prot
      B4DSL4, E9PG87, Q8IUI6, Q92870

    22. XM_017008144.3 → XP_016863633.1  amyloid beta precursor protein binding family B member 2 isoform X2

      UniProtKB/TrEMBL
      B4E2F2
      Conserved Domains (3) summary
      cd01271
      Location:584 → 710
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:416 → 555
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    23. XM_017008154.3 → XP_016863643.1  amyloid beta precursor protein binding family B member 2 isoform X8

      UniProtKB/TrEMBL
      H0YAJ5
      Conserved Domains (3) summary
      cd01271
      Location:562 → 688
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:396 → 533
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    24. XM_017008151.3 → XP_016863640.1  amyloid beta precursor protein binding family B member 2 isoform X6

      UniProtKB/TrEMBL
      H0YAJ5
      Conserved Domains (3) summary
      cd01271
      Location:564 → 690
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:396 → 535
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    25. XM_017008145.3 → XP_016863634.1  amyloid beta precursor protein binding family B member 2 isoform X3

      UniProtKB/TrEMBL
      B4E2F2
      Conserved Domains (3) summary
      cd01271
      Location:583 → 709
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417 → 554
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    26. XM_006714008.5 → XP_006714071.1  amyloid beta precursor protein binding family B member 2 isoform X1

      See identical proteins and their annotated locations for XP_006714071.1

      UniProtKB/TrEMBL
      B4E2F2
      Conserved Domains (3) summary
      cd01271
      Location:585 → 711
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417 → 556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    27. XM_017008146.3 → XP_016863635.1  amyloid beta precursor protein binding family B member 2 isoform X5

      UniProtKB/TrEMBL
      B4E2F2

    28. XM_006714012.5 → XP_006714075.1  amyloid beta precursor protein binding family B member 2 isoform X7

      UniProtKB/TrEMBL
      H0YAJ5
      Conserved Domains (3) summary
      cd01271
      Location:563 → 689
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395 → 534
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    29. XM_006714010.5 → XP_006714073.1  amyloid beta precursor protein binding family B member 2 isoform X2

      UniProtKB/TrEMBL
      B4E2F2
      Conserved Domains (3) summary
      cd01271
      Location:584 → 710
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:416 → 555
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292 → 320
      WW; WW domain

    30. XM_011513687.4 → XP_011511989.1  amyloid beta precursor protein binding family B member 2 isoform X8

      UniProtKB/TrEMBL
      H0YAJ5
      Conserved Domains (3) summary
      cd01271
      Location:562 → 688
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:396 → 533
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    31. XM_006714011.5 → XP_006714074.1  amyloid beta precursor protein binding family B member 2 isoform X6

      UniProtKB/TrEMBL
      H0YAJ5
      Conserved Domains (3) summary
      cd01271
      Location:564 → 690
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:396 → 535
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    32. XM_006714005.5 → XP_006714068.1  amyloid beta precursor protein binding family B member 2 isoform X1

      See identical proteins and their annotated locations for XP_006714068.1

      UniProtKB/TrEMBL
      B4E2F2
      Conserved Domains (3) summary
      cd01271
      Location:585 → 711
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417 → 556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293 → 321
      WW; WW domain

    33. XM_047450163.1 → XP_047306119.1  amyloid beta precursor protein binding family B member 2 isoform X1

    34. XM_047450168.1 → XP_047306124.1  amyloid beta precursor protein binding family B member 2 isoform X2

    35. XM_047450174.1 → XP_047306130.1  amyloid beta precursor protein binding family B member 2 isoform X3

    36. XM_047450162.1 → XP_047306118.1  amyloid beta precursor protein binding family B member 2 isoform X1

    37. XM_047450189.1 → XP_047306145.1  amyloid beta precursor protein binding family B member 2 isoform X9

      UniProtKB/TrEMBL
      G5E9Y1

    38. XM_047450182.1 → XP_047306138.1  amyloid beta precursor protein binding family B member 2 isoform X7

    39. XM_047450177.1 → XP_047306133.1  amyloid beta precursor protein binding family B member 2 isoform X4

      UniProtKB/Swiss-Prot
      B4DSL4, E9PG87, Q8IUI6, Q92870

    40. XM_047450167.1 → XP_047306123.1  amyloid beta precursor protein binding family B member 2 isoform X2

    41. XM_047450185.1 → XP_047306141.1  amyloid beta precursor protein binding family B member 2 isoform X8

    42. XM_047450171.1 → XP_047306127.1  amyloid beta precursor protein binding family B member 2 isoform X3

    43. XM_047450160.1 → XP_047306116.1  amyloid beta precursor protein binding family B member 2 isoform X1

    44. XM_047450188.1 → XP_047306144.1  amyloid beta precursor protein binding family B member 2 isoform X8

      Related
      ENSP00000427307.1, ENST00000513611.5

    45. XM_047450176.1 → XP_047306132.1  amyloid beta precursor protein binding family B member 2 isoform X3

    46. XM_047450165.1 → XP_047306121.1  amyloid beta precursor protein binding family B member 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      40783978..41188337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349910.1 → XP_054205885.1  amyloid beta precursor protein binding family B member 2 isoform X9

    2. XM_054349892.1 → XP_054205867.1  amyloid beta precursor protein binding family B member 2 isoform X4

    3. XM_054349879.1 → XP_054205854.1  amyloid beta precursor protein binding family B member 2 isoform X2

    4. XM_054349906.1 → XP_054205881.1  amyloid beta precursor protein binding family B member 2 isoform X8

    5. XM_054349886.1 → XP_054205861.1  amyloid beta precursor protein binding family B member 2 isoform X3

    6. XM_054349872.1 → XP_054205847.1  amyloid beta precursor protein binding family B member 2 isoform X1

    7. XM_054349909.1 → XP_054205884.1  amyloid beta precursor protein binding family B member 2 isoform X9

    8. XM_054349901.1 → XP_054205876.1  amyloid beta precursor protein binding family B member 2 isoform X7

    9. XM_054349891.1 → XP_054205866.1  amyloid beta precursor protein binding family B member 2 isoform X4

    10. XM_054349875.1 → XP_054205850.1  amyloid beta precursor protein binding family B member 2 isoform X2

    11. XM_054349905.1 → XP_054205880.1  amyloid beta precursor protein binding family B member 2 isoform X8

    12. XM_054349884.1 → XP_054205859.1  amyloid beta precursor protein binding family B member 2 isoform X3

    13. XM_054349869.1 → XP_054205844.1  amyloid beta precursor protein binding family B member 2 isoform X1

    14. XM_054349900.1 → XP_054205875.1  amyloid beta precursor protein binding family B member 2 isoform X7

    15. XM_054349890.1 → XP_054205865.1  amyloid beta precursor protein binding family B member 2 isoform X4

    16. XM_054349880.1 → XP_054205855.1  amyloid beta precursor protein binding family B member 2 isoform X2

    17. XM_054349883.1 → XP_054205858.1  amyloid beta precursor protein binding family B member 2 isoform X3

    18. XM_054349867.1 → XP_054205842.1  amyloid beta precursor protein binding family B member 2 isoform X1

    19. XM_054349894.1 → XP_054205869.1  amyloid beta precursor protein binding family B member 2 isoform X5

    20. XM_054349899.1 → XP_054205874.1  amyloid beta precursor protein binding family B member 2 isoform X7

    21. XM_054349889.1 → XP_054205864.1  amyloid beta precursor protein binding family B member 2 isoform X4

    22. XM_054349876.1 → XP_054205851.1  amyloid beta precursor protein binding family B member 2 isoform X2

    23. XM_054349904.1 → XP_054205879.1  amyloid beta precursor protein binding family B member 2 isoform X8

    24. XM_054349896.1 → XP_054205871.1  amyloid beta precursor protein binding family B member 2 isoform X6

    25. XM_054349881.1 → XP_054205856.1  amyloid beta precursor protein binding family B member 2 isoform X3

    26. XM_054349866.1 → XP_054205841.1  amyloid beta precursor protein binding family B member 2 isoform X1

    27. XM_054349893.1 → XP_054205868.1  amyloid beta precursor protein binding family B member 2 isoform X5

    28. XM_054349897.1 → XP_054205872.1  amyloid beta precursor protein binding family B member 2 isoform X7

    29. XM_054349874.1 → XP_054205849.1  amyloid beta precursor protein binding family B member 2 isoform X2

    30. XM_054349902.1 → XP_054205877.1  amyloid beta precursor protein binding family B member 2 isoform X8

    31. XM_054349895.1 → XP_054205870.1  amyloid beta precursor protein binding family B member 2 isoform X6

    32. XM_054349865.1 → XP_054205840.1  amyloid beta precursor protein binding family B member 2 isoform X1

    33. XM_054349871.1 → XP_054205846.1  amyloid beta precursor protein binding family B member 2 isoform X1

    34. XM_054349878.1 → XP_054205853.1  amyloid beta precursor protein binding family B member 2 isoform X2

    35. XM_054349885.1 → XP_054205860.1  amyloid beta precursor protein binding family B member 2 isoform X3

    36. XM_054349870.1 → XP_054205845.1  amyloid beta precursor protein binding family B member 2 isoform X1

    37. XM_054349908.1 → XP_054205883.1  amyloid beta precursor protein binding family B member 2 isoform X9

    38. XM_054349898.1 → XP_054205873.1  amyloid beta precursor protein binding family B member 2 isoform X7

    39. XM_054349888.1 → XP_054205863.1  amyloid beta precursor protein binding family B member 2 isoform X4

    40. XM_054349877.1 → XP_054205852.1  amyloid beta precursor protein binding family B member 2 isoform X2

    41. XM_054349903.1 → XP_054205878.1  amyloid beta precursor protein binding family B member 2 isoform X8

    42. XM_054349882.1 → XP_054205857.1  amyloid beta precursor protein binding family B member 2 isoform X3

    43. XM_054349868.1 → XP_054205843.1  amyloid beta precursor protein binding family B member 2 isoform X1

    44. XM_054349873.1 → XP_054205848.1  amyloid beta precursor protein binding family B member 2 isoform X1

    45. XM_054349907.1 → XP_054205882.1  amyloid beta precursor protein binding family B member 2 isoform X8

    46. XM_054349887.1 → XP_054205862.1  amyloid beta precursor protein binding family B member 2 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92870.3 GenPept UniProtKB/Swiss-Prot:Q92870

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