PICK1 protein interacting with PRKCA 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PICK1provided by HGNC
Official Full Name: protein interacting with PRKCA 1provided by HGNC
Primary source: HGNC:HGNC:9394
See related: Ensembl:ENSG00000100151 MIM:605926; AllianceGenome:HGNC:9394
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PICK; PRKCABP
Summary: The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in prostate (RPKM 10.0), testis (RPKM 8.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q13.1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (38057255..38075701)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (38518878..38537327)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (38453262..38471708)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment.
Title: Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment.
Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells.
Title: Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells.
The Scaffold Protein PICK1 as a Target in Chronic Pain.
Title: The Scaffold Protein PICK1 as a Target in Chronic Pain.
Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis.
Title: Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis.
Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case-control study.
Title: Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case-control study.
PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval.
Title: PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval.
Protein interacting with C-kinase 1 is involved in epithelial-mesenchymal transformation and suppresses progress of gastric cancer.
Title: Protein interacting with C-kinase 1 is involved in epithelial-mesenchymal transformation and suppresses progress of gastric cancer.
PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury.
Title: PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury.
A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain.
Title: A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain.
Arf1, AP1, and PICK1 are key coordinators of actin polymerization.
Title: The Host GTPase Arf1 and Its Effectors AP1 and PICK1 Stimulate Actin Polymerization and Exocytosis To Promote Entry of Listeria monocytogenes.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables G protein-coupled receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables membrane curvature sensor activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase C binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase C binding	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to decreased oxygen levels	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to glucose starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendritic spine maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendritic spine maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendritic spine organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in glial cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-term synaptic depression	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuronal ion channel clustering	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in endocytic vesicle membrane	TAS Traceable Author Statement more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PRKCA-binding protein

Names: protein interacting with C kinase 1; protein kinase C-alpha-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039583.1 → NP_001034672.1 PRKCA-binding protein

See identical proteins and their annotated locations for NP_001034672.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AK092818, BC017561, CN482899

Consensus CDS

CCDS13965.1

UniProtKB/Swiss-Prot

B3KS52, O95906, Q9NRD5

UniProtKB/TrEMBL

B3KM22

Related

ENSP00000385205.3, ENST00000404072.7

Conserved Domains (2) summary

cd07659
Location:146 → 360

BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1

smart00228
Location:19 → 99

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
NM_001039584.1 → NP_001034673.1 PRKCA-binding protein

See identical proteins and their annotated locations for NP_001034673.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AK092818, BC017561

Consensus CDS

CCDS13965.1

UniProtKB/Swiss-Prot

B3KS52, O95906, Q9NRD5

UniProtKB/TrEMBL

B3KM22

Related

ENST00000484021.5

Conserved Domains (2) summary

cd07659
Location:146 → 360

BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1

smart00228
Location:19 → 99

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
NM_012407.4 → NP_036539.1 PRKCA-binding protein

See identical proteins and their annotated locations for NP_036539.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

AK092818, BC017561

Consensus CDS

CCDS13965.1

UniProtKB/Swiss-Prot

B3KS52, O95906, Q9NRD5

UniProtKB/TrEMBL

B3KM22

Related

ENSP00000349465.3, ENST00000356976.8

Conserved Domains (2) summary

cd07659
Location:146 → 360

BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1

smart00228
Location:19 → 99

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000022.11 Reference GRCh38.p14 Primary Assembly

Range

38057255..38075701

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047441609.1 → XP_047297565.1 PRKCA-binding protein isoform X1
XM_047441610.1 → XP_047297566.1 PRKCA-binding protein isoform X1
XM_011530517.4 → XP_011528819.1 PRKCA-binding protein isoform X1

UniProtKB/TrEMBL

B3KM22

Conserved Domains (2) summary

cd07659
Location:147 → 342

BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1

smart00228
Location:19 → 99

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
XM_047441611.1 → XP_047297567.1 PRKCA-binding protein isoform X2
XM_047441613.1 → XP_047297569.1 PRKCA-binding protein isoform X4
XM_047441612.1 → XP_047297568.1 PRKCA-binding protein isoform X3