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    TPX2 TPX2 microtubule nucleation factor [ Homo sapiens (human) ]

    Gene ID: 22974, updated on 10-Dec-2024

    Summary

    Official Symbol
    TPX2provided by HGNC
    Official Full Name
    TPX2 microtubule nucleation factorprovided by HGNC
    Primary source
    HGNC:HGNC:1249
    See related
    Ensembl:ENSG00000088325 MIM:605917; AllianceGenome:HGNC:1249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIL2; p100; DIL-2; HCTP4; FLS353; HCA519; REPP86; C20orf1; C20orf2; GD:C20orf1
    Summary
    Enables importin-alpha family protein binding activity; molecular adaptor activity; and protein kinase binding activity. Involved in activation of protein kinase activity; microtubule cytoskeleton organization; and negative regulation of microtubule depolymerization. Located in intercellular bridge; nucleoplasm; and spindle. Is active in spindle. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 19.8), bone marrow (RPKM 18.0) and 16 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TPX2 in Genome Data Viewer
    Location:
    20q11.21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (31739290..31801800)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (33463246..33526408)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30327093..30389603)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs2050 Neighboring gene BCL2 like 1 Neighboring gene BCL2L1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30285857-30286804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17693 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30300575-30301102 Neighboring gene Sharpr-MPRA regulatory region 251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17695 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30310290-30311045 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30311046-30311800 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:30316344-30316520 Neighboring gene apoptotic BCL2L1-antisense long non-coding RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17699 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30373423-30373922 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30376059-30376558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30403487-30404289 Neighboring gene ATP synthase membrane subunit f pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30407643-30408184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12765 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30411041-30411568 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30411569-30412095 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30412296-30412796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30414489-30414989 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30421849-30422479 Neighboring gene myosin light chain kinase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables importin-alpha family protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mitotic spindle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of mitotic spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon hillock IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    colocalizes_with spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    targeting protein for Xklp2
    Names
    TPX2, microtubule-associated protein homolog
    TPX2, microtubule-associated, homolog
    differentially expressed in cancerous and non-cancerous lung cells 2
    differentially expressed in cancerous and noncancerous lung cells 2
    differentially expressed in lung cells
    hepatocellular carcinoma-associated antigen 519
    hepatocellular carcinoma-associated antigen 90
    preferentially expressed in colorectal cancer
    protein fls353
    restricted expression proliferation associated protein 100

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012112.5NP_036244.2  targeting protein for Xklp2

      See identical proteins and their annotated locations for NP_036244.2

      Status: VALIDATED

      Source sequence(s)
      AF098158, BC020207, CB960160
      Consensus CDS
      CCDS13190.1
      UniProtKB/Swiss-Prot
      Q96RR5, Q9H1R4, Q9NRA3, Q9UFN9, Q9UL00, Q9ULW0, Q9Y2M1
      UniProtKB/TrEMBL
      B3KM90, Q643R0
      Related
      ENSP00000300403.6, ENST00000300403.11
      Conserved Domains (3) summary
      pfam09041
      Location:168
      Aurora-A_bind; Aurora-A binding
      pfam06886
      Location:660740
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam12214
      Location:367489
      TPX2_importin; Cell cycle regulated microtubule associated protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      31739290..31801800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528700.4XP_011527002.1  targeting protein for Xklp2 isoform X2

      UniProtKB/TrEMBL
      B3KM90
      Conserved Domains (3) summary
      pfam06886
      Location:657711
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam09041
      Location:168
      Aurora-A_bind; Aurora-A binding
      pfam12214
      Location:367489
      TPX2_importin; Cell cycle regulated microtubule associated protein
    2. XM_011528699.3XP_011527001.1  targeting protein for Xklp2 isoform X1

      See identical proteins and their annotated locations for XP_011527001.1

      UniProtKB/Swiss-Prot
      Q96RR5, Q9H1R4, Q9NRA3, Q9UFN9, Q9UL00, Q9ULW0, Q9Y2M1
      UniProtKB/TrEMBL
      B3KM90, Q643R0
      Conserved Domains (3) summary
      pfam09041
      Location:168
      Aurora-A_bind; Aurora-A binding
      pfam06886
      Location:660740
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam12214
      Location:367489
      TPX2_importin; Cell cycle regulated microtubule associated protein
    3. XM_047440018.1XP_047295974.1  targeting protein for Xklp2 isoform X2

      UniProtKB/TrEMBL
      B3KM90
    4. XM_011528697.3XP_011526999.1  targeting protein for Xklp2 isoform X1

      See identical proteins and their annotated locations for XP_011526999.1

      UniProtKB/Swiss-Prot
      Q96RR5, Q9H1R4, Q9NRA3, Q9UFN9, Q9UL00, Q9ULW0, Q9Y2M1
      UniProtKB/TrEMBL
      B3KM90, Q643R0
      Conserved Domains (3) summary
      pfam09041
      Location:168
      Aurora-A_bind; Aurora-A binding
      pfam06886
      Location:660740
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam12214
      Location:367489
      TPX2_importin; Cell cycle regulated microtubule associated protein
    5. XM_047440017.1XP_047295973.1  targeting protein for Xklp2 isoform X2

      UniProtKB/TrEMBL
      B3KM90

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      33463246..33526408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323205.1XP_054179180.1  targeting protein for Xklp2 isoform X1

      UniProtKB/Swiss-Prot
      Q96RR5, Q9H1R4, Q9NRA3, Q9UFN9, Q9UL00, Q9ULW0, Q9Y2M1
      UniProtKB/TrEMBL
      B3KM90, Q643R0
    2. XM_054323208.1XP_054179183.1  targeting protein for Xklp2 isoform X2

      UniProtKB/TrEMBL
      B3KM90
    3. XM_054323207.1XP_054179182.1  targeting protein for Xklp2 isoform X2

      UniProtKB/TrEMBL
      B3KM90
    4. XM_054323206.1XP_054179181.1  targeting protein for Xklp2 isoform X1

      UniProtKB/Swiss-Prot
      Q96RR5, Q9H1R4, Q9NRA3, Q9UFN9, Q9UL00, Q9ULW0, Q9Y2M1
      UniProtKB/TrEMBL
      B3KM90, Q643R0
    5. XM_054323209.1XP_054179184.1  targeting protein for Xklp2 isoform X2

      UniProtKB/TrEMBL
      B3KM90