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    CD8B2 CD8B family member 2 [ Homo sapiens (human) ]

    Gene ID: 927, updated on 4-Jan-2025

    Summary

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    Official Symbol
    CD8B2provided by HGNC
    Official Full Name
    CD8B family member 2provided by HGNC
    Primary source
    HGNC:HGNC:1708
    See related
    Ensembl:ENSG00000254126 AllianceGenome:HGNC:1708
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD8BP
    Summary
    Predicted to enable MHC class I protein binding activity and coreceptor activity. Predicted to be involved in adaptive immune response and regulation of immune response. Predicted to be located in plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See CD8B2 in Genome Data Viewer
    Location:
    2q12.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (106487364..106544297)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (106948808..107005766)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (107103820..107160753)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene plasminogen like A (pseudogene) Neighboring gene RANBP2 like and GRIP domain containing 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:107056244-107056460 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:107060799-107061300 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:107084140-107084332 Neighboring gene anaphase-promoting complex subunit 1-like Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:107118971-107119470 Neighboring gene uncharacterized LOC124907863 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:107206419-107206639 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Chromosomal mapping of the second human CD8B gene locus. Zhang XL, et al. Immunogenetics, 1996. PMID 8575821
    2. Duplication of the CD8 beta-chain gene as a marker of the man-gorilla-chimpanzee clade. Delarbre C, et al. Proc Natl Acad Sci U S A, 1993 Aug 1. PMID 8346216, Free PMC Article
    3. Transcriptional diversity at the duplicated human CD8 beta loci. DiSanto JP, et al. Eur J Immunol, 1993 Feb. PMID 8436166
    4. Recent duplication of the two human CD8 beta-chain genes. Nakayama K, et al. J Immunol, 1992 Mar 15. PMID 1541829
    5. Sequence and evolution of the human T-cell antigen receptor beta-chain genes. Tunnacliffe A, et al. Proc Natl Acad Sci U S A, 1985 Aug. PMID 3860845, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MHC class I protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    T-cell surface glycoprotein CD8 beta-2 chain
    Names
    CD8 antigen, beta polypeptide pseudogene
    CD8b molecule pseudogene
    CD8b pseudogene
    CD8b2 molecule
    putative T-cell surface glycoprotein CD8 beta-2 chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001349727.2 → NP_001336656.1  T-cell surface glycoprotein CD8 beta-2 chain isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC108868, CA867855, HY085838
      Consensus CDS
      CCDS86870.1
      UniProtKB/Swiss-Prot
      A0A2R8Y7N9, A6NJW9
      UniProtKB/TrEMBL
      E9PD41
      Related
      ENSP00000496416.1, ENST00000643224.2
      Conserved Domains (1) summary
      cd07700
      Location:29 → 134
      IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

    2. NM_001368307.2 → NP_001355236.1  T-cell surface glycoprotein CD8 beta-2 chain isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC108868
      Consensus CDS
      CCDS92827.1
      UniProtKB/TrEMBL
      A0A2R8Y6U7, B4E0F8, E7EPH5
      Related
      ENSP00000495575.1, ENST00000416057.2
      Conserved Domains (1) summary
      cd07700
      Location:29 → 134
      IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      106487364..106544297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453217.2 → XP_024308985.1  T-cell surface glycoprotein CD8 beta-2 chain isoform X1

      UniProtKB/TrEMBL
      B4E0F8, E7EPH5, E9PD41
      Conserved Domains (1) summary
      cd07700
      Location:29 → 134
      IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      106948808..107005766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_002423.4: Suppressed sequence

      Description
      NG_002423.4: This RefSeq was removed because it is now thought this locus is transcribed.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NJW9.3 GenPept UniProtKB/Swiss-Prot:A6NJW9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials