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    SERTAD3 SERTA domain containing 3 [ Homo sapiens (human) ]

    Gene ID: 29946, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SERTAD3provided by HGNC
    Official Full Name
    SERTA domain containing 3provided by HGNC
    Primary source
    HGNC:HGNC:17931
    See related
    Ensembl:ENSG00000167565 MIM:612125; AllianceGenome:HGNC:17931
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RBT1
    Summary
    The protein encoded by this gene was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in cancer cell lines compared to normal cell lines. This protein has also been shown to be a strong transcriptional co-activator. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in placenta (RPKM 11.9), prostate (RPKM 10.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SERTAD3 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (40440844..40444335, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (43261506..43264994, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40946751..40950242, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene periaxin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14650 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14651 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40915393-40915986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40915987-40916578 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40920095-40920743 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:40926600-40927100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10623 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:40930422-40931224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10624 Neighboring gene SERTA domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40939147-40939975 Neighboring gene CRISPRi-validated cis-regulatory element chr19.4185 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10627 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10629 Neighboring gene SERTAD3 antisense RNA 1 Neighboring gene biliverdin reductase B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14655

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Overexpression of SERTAD3, a putative oncogene located within the 19q13 amplicon, induces E2F activity and promotes tumor growth. Darwish H, et al. Oncogene, 2007 Jun 21. PMID 17260023
    2. Type-IInterferon-Inducible SERTAD3 Inhibits Influenza A Virus Replication by Blocking the Assembly of Viral RNA Polymerase Complex. Sun N, et al. Cell Rep, 2020 Nov 3. PMID 33147462
    3. RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A. Cho JM, et al. Nucleic Acids Res, 2000 Sep 15. PMID 10982866, Free PMC Article
    4. SEI family of nuclear factors regulates p53-dependent transcriptional activation. Watanabe-Fukunaga R, et al. Genes Cells, 2005 Aug. PMID 16098148
    5. TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. Hsu SI, et al. EMBO J, 2001 May 1. PMID 11331592, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Type-IInterferon-Inducible SERTAD3 Inhibits Influenza A Virus Replication by Blocking the Assembly of Viral RNA Polymerase Complex.
      Title: Type-IInterferon-Inducible SERTAD3 Inhibits Influenza A Virus Replication by Blocking the Assembly of Viral RNA Polymerase Complex.
    2. Transduction of stably expressed human SERTAD3 induces cell transformation in vitro and tumor formation in mice via a transcription factor E2F-dependent mechanism.
      Title: Overexpression of SERTAD3, a putative oncogene located within the 19q13 amplicon, induces E2F activity and promotes tumor growth.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SERTA domain-containing protein 3
    Names
    RPA-binding trans-activator
    replication protein-binding trans-activator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013368.4 → NP_037500.2  SERTA domain-containing protein 3

      See identical proteins and their annotated locations for NP_037500.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC010271, AF192529, AW242302, BC014061
      Consensus CDS
      CCDS12558.1
      UniProtKB/Swiss-Prot
      B3KQB3, Q96CQ2, Q9UJW9
      UniProtKB/TrEMBL
      M0QXL4
      Related
      ENSP00000375882.3, ENST00000392028.8
      Conserved Domains (1) summary
      pfam06031
      Location:33 → 66
      SERTA; SERTA motif

    2. NM_203344.3 → NP_976219.1  SERTA domain-containing protein 3

      See identical proteins and their annotated locations for NP_976219.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AW242302, BC050643
      Consensus CDS
      CCDS12558.1
      UniProtKB/Swiss-Prot
      B3KQB3, Q96CQ2, Q9UJW9
      UniProtKB/TrEMBL
      M0QXL4
      Related
      ENSP00000325414.2, ENST00000322354.4
      Conserved Domains (1) summary
      pfam06031
      Location:33 → 66
      SERTA; SERTA motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      40440844..40444335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438716.1 → XP_047294672.1  SERTA domain-containing protein 3 isoform X1

    2. XM_006723179.4 → XP_006723242.1  SERTA domain-containing protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006723242.1

      UniProtKB/Swiss-Prot
      B3KQB3, Q96CQ2, Q9UJW9
      UniProtKB/TrEMBL
      M0QXL4
      Related
      ENSP00000469245.1, ENST00000599706.1
      Conserved Domains (1) summary
      pfam06031
      Location:33 → 66
      SERTA; SERTA motif

    3. XM_047438717.1 → XP_047294673.1  SERTA domain-containing protein 3 isoform X1

    4. XM_047438718.1 → XP_047294674.1  SERTA domain-containing protein 3 isoform X2

      UniProtKB/Swiss-Prot
      B3KQB3, Q96CQ2, Q9UJW9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      43261506..43264994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320771.1 → XP_054176746.1  SERTA domain-containing protein 3 isoform X1

    2. XM_054320774.1 → XP_054176749.1  SERTA domain-containing protein 3 isoform X2

      UniProtKB/Swiss-Prot
      B3KQB3, Q96CQ2, Q9UJW9

    3. XM_054320772.1 → XP_054176747.1  SERTA domain-containing protein 3 isoform X1

    4. XM_054320773.1 → XP_054176748.1  SERTA domain-containing protein 3 isoform X2

      UniProtKB/Swiss-Prot
      B3KQB3, Q96CQ2, Q9UJW9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UJW9.2 GenPept UniProtKB/Swiss-Prot:Q9UJW9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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