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    ZNF232 zinc finger protein 232 [ Homo sapiens (human) ]

    Gene ID: 7775, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF232provided by HGNC
    Official Full Name
    zinc finger protein 232provided by HGNC
    Primary source
    HGNC:HGNC:13026
    See related
    Ensembl:ENSG00000167840 MIM:616463; AllianceGenome:HGNC:13026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZSCAN11
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 6.2), testis (RPKM 4.2) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF232 in Genome Data Viewer
    Location:
    17p13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (5105734..5123116, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (4999106..5016496, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (5009029..5026411, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:4981230-4982101 Neighboring gene ZFP3 divergent transcript Neighboring gene ZFP3 zinc finger protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11566 Neighboring gene ZNF232 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:5033804-5034304 Neighboring gene ubiquitin specific peptidase 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:5040130-5040801 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:5040802-5041472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:5042145-5042815 Neighboring gene MPRA-validated peak2704 silencer Neighboring gene zinc finger protein 594 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8065 Neighboring gene ZNF594 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8066 Neighboring gene SLP adaptor and CSK interacting membrane protein Neighboring gene MPRA-validated peak2705 silencer

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF232: structure and expression analysis of a novel human C(2)H(2) zinc finger gene, member of the SCAN/LeR domain subfamily. Mavrogiannis LA, et al. Biochim Biophys Acta, 2001 Apr 16. PMID 11311944
    2. USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization. Du L, et al. Cancer Res, 2021 Jul 15. PMID 33903120
    3. An investigation into the human serum "interactome". Zhou M, et al. Electrophoresis, 2004 May. PMID 15174051
    4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
    5. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 232
    Names
    zinc finger and SCAN domain-containing protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320952.1 → NP_001307881.1  zinc finger protein 232 isoform b

      Status: VALIDATED

      Source sequence(s)
      AK225622, BQ184519, BQ641476
      Consensus CDS
      CCDS82043.1
      Related
      ENSP00000461305.1, ENST00000575898.5
      Conserved Domains (6) summary
      smart00431
      Location:75 → 188
      SCAN; leucine rich region
      COG5048
      Location:294 → 400
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:324 → 344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:294 → 316
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:75 → 162
      SCAN; SCAN domain
      pfam13465
      Location:364 → 389
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001320953.2 → NP_001307882.1  zinc finger protein 232 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: Variants 3 and 4 encode the same isoform (c).
      Source sequence(s)
      AC012146
      Conserved Domains (4) summary
      smart00431
      Location:48 → 161
      SCAN; leucine rich region
      COG5048
      Location:302 → 382
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:306 → 326
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:276 → 298
      zf-C2H2; Zinc finger, C2H2 type

    3. NM_001320954.2 → NP_001307883.1  zinc finger protein 232 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: Variants 3 and 4 encode the same isoform (c).
      Source sequence(s)
      AC012146
      Conserved Domains (4) summary
      smart00431
      Location:48 → 161
      SCAN; leucine rich region
      COG5048
      Location:302 → 382
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:306 → 326
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:276 → 298
      zf-C2H2; Zinc finger, C2H2 type

    4. NM_001320955.1 → NP_001307884.1  zinc finger protein 232 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC012146
      Consensus CDS
      CCDS92233.1
      UniProtKB/TrEMBL
      A0A8Q3SIR0
      Related
      ENSP00000512696.1, ENST00000696535.1
      Conserved Domains (5) summary
      COG5048
      Location:301 → 381
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:305 → 325
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:275 → 297
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:75 → 139
      SCAN; SCAN domain
      pfam13465
      Location:345 → 370
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001395550.1 → NP_001382479.1  zinc finger protein 232 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC012146
      Conserved Domains (5) summary
      COG5048
      Location:300 → 352
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:248 → 268
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:218 → 240
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:288 → 313
      zf-H2C2_2; Zinc-finger double domain
      cl02605
      Location:27 → 91
      SCAN; SCAN oligomerization domain

    6. NM_001395551.1 → NP_001382480.1  zinc finger protein 232 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC012146
      Conserved Domains (4) summary
      smart00431
      Location:48 → 161
      SCAN; leucine rich region
      COG5048
      Location:267 → 373
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:297 → 317
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:337 → 362
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001395552.1 → NP_001382481.1  zinc finger protein 232 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC012146
      Conserved Domains (5) summary
      COG5048
      Location:309 → 361
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:257 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:227 → 249
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:297 → 322
      zf-H2C2_2; Zinc-finger double domain
      cl02605
      Location:27 → 91
      SCAN; SCAN oligomerization domain

    8. NM_014519.6 → NP_055334.2  zinc finger protein 232 isoform a

      See identical proteins and their annotated locations for NP_055334.2

      Status: VALIDATED

      Source sequence(s)
      AC012146
      Consensus CDS
      CCDS11068.1
      UniProtKB/Swiss-Prot
      I3L4J6, Q9UNY5
      Related
      ENSP00000250076.3, ENST00000250076.8
      Conserved Domains (6) summary
      smart00431
      Location:75 → 188
      SCAN; leucine rich region
      COG5048
      Location:303 → 409
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:333 → 353
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:303 → 325
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:75 → 162
      SCAN; SCAN domain
      pfam13465
      Location:373 → 398
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      5105734..5123116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436671.1 → XP_047292627.1  zinc finger protein 232 isoform X2

    2. XM_047436668.1 → XP_047292624.1  zinc finger protein 232 isoform X1

      UniProtKB/Swiss-Prot
      I3L4J6, Q9UNY5

    3. XM_047436674.1 → XP_047292630.1  zinc finger protein 232 isoform X5

    4. XM_047436669.1 → XP_047292625.1  zinc finger protein 232 isoform X1

      UniProtKB/Swiss-Prot
      I3L4J6, Q9UNY5

    5. XM_047436670.1 → XP_047292626.1  zinc finger protein 232 isoform X1

      UniProtKB/Swiss-Prot
      I3L4J6, Q9UNY5

    6. XM_047436673.1 → XP_047292629.1  zinc finger protein 232 isoform X4

    7. XM_047436672.1 → XP_047292628.1  zinc finger protein 232 isoform X3

      UniProtKB/TrEMBL
      A0A8Q3SIT7
      Related
      ENSP00000512697.1, ENST00000696536.1

    8. XM_011524006.4 → XP_011522308.1  zinc finger protein 232 isoform X3

      See identical proteins and their annotated locations for XP_011522308.1

      UniProtKB/TrEMBL
      A0A8Q3SIT7
      Conserved Domains (6) summary
      smart00431
      Location:27 → 140
      SCAN; leucine rich region
      COG5048
      Location:281 → 361
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:285 → 305
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:255 → 277
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:27 → 114
      SCAN; SCAN domain
      pfam13465
      Location:325 → 350
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      4999106..5016496 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317081.1 → XP_054173056.1  zinc finger protein 232 isoform X2

    2. XM_054317078.1 → XP_054173053.1  zinc finger protein 232 isoform X1

      UniProtKB/Swiss-Prot
      I3L4J6, Q9UNY5

    3. XM_054317085.1 → XP_054173060.1  zinc finger protein 232 isoform X5

    4. XM_054317079.1 → XP_054173054.1  zinc finger protein 232 isoform X1

      UniProtKB/Swiss-Prot
      I3L4J6, Q9UNY5

    5. XM_054317080.1 → XP_054173055.1  zinc finger protein 232 isoform X1

      UniProtKB/Swiss-Prot
      I3L4J6, Q9UNY5

    6. XM_054317084.1 → XP_054173059.1  zinc finger protein 232 isoform X4

    7. XM_054317082.1 → XP_054173057.1  zinc finger protein 232 isoform X3

      UniProtKB/TrEMBL
      A0A8Q3SIT7

    8. XM_054317083.1 → XP_054173058.1  zinc finger protein 232 isoform X3

      UniProtKB/TrEMBL
      A0A8Q3SIT7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UNY5.2 GenPept UniProtKB/Swiss-Prot:Q9UNY5

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