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    OXGR1 oxoglutarate receptor 1 [ Homo sapiens (human) ]

    Gene ID: 27199, updated on 10-Dec-2024

    Summary

    Official Symbol
    OXGR1provided by HGNC
    Official Full Name
    oxoglutarate receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:4531
    See related
    Ensembl:ENSG00000165621 MIM:606922; AllianceGenome:HGNC:4531
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    aKGR; CAON2; GPR80; GPR99; P2Y15; P2RY15
    Summary
    This gene encodes a G protein-coupled receptor (GPCR) that belongs to the oxoglutarate receptor family within the GPCR superfamily. The encoded protein is activated by the citric acid intermediate, oxoglutarate, as well as several cysteinyl leukotrienes, including leukotrienes E4, C4 and D4, which are implicated in many inflammatory disorders. In mice, a knock-out of this gene leads to middle ear inflammation, changes in the mucosal epithelium, and an increase in fluid behind the eardrum, and is associated with hearing loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
    Expression
    Broad expression in kidney (RPKM 1.0), colon (RPKM 0.6) and 14 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See OXGR1 in Genome Data Viewer
    Location:
    13q32.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (96985713..96994730, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (96189803..96198827, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (97637967..97646984, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 359 Neighboring gene TUB like protein 3 pseudogene 1 Neighboring gene RN7SK pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7886 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124903196

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC119206, MGC119207, MGC119208

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    2-oxoglutarate receptor 1
    Names
    G protein-coupled receptor 80
    G-protein coupled receptor 99
    P2Y purinoceptor 15
    P2Y-like GPCR
    P2Y-like nucleotide receptor
    alpha-ketoglutarate receptor 1
    oxoglutarate (alpha-ketoglutarate) receptor 1
    seven transmembrane helix receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346194.2NP_001333123.1  2-oxoglutarate receptor 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK122639, AL356486, DN993601
      Consensus CDS
      CCDS9482.1
      UniProtKB/Swiss-Prot
      Q5T5A7, Q86TL1, Q96P68
      UniProtKB/TrEMBL
      B2R986
      Related
      ENSP00000437356.2, ENST00000541038.2
      Conserved Domains (1) summary
      cd15375
      Location:34313
      7tmA_OXGR1; 2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001346195.2NP_001333124.1  2-oxoglutarate receptor 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK122639, AL356486, DB204461
      Consensus CDS
      CCDS9482.1
      UniProtKB/Swiss-Prot
      Q5T5A7, Q86TL1, Q96P68
      UniProtKB/TrEMBL
      B2R986
      Conserved Domains (1) summary
      cd15375
      Location:34313
      7tmA_OXGR1; 2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001346196.2NP_001333125.1  2-oxoglutarate receptor 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK122639, AK313684, AL356486, DN993601
      Consensus CDS
      CCDS9482.1
      UniProtKB/Swiss-Prot
      Q5T5A7, Q86TL1, Q96P68
      UniProtKB/TrEMBL
      B2R986
      Related
      ENSP00000438800.1, ENST00000543457.6
      Conserved Domains (1) summary
      cd15375
      Location:34313
      7tmA_OXGR1; 2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. NM_001346197.2NP_001333126.1  2-oxoglutarate receptor 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate exon and uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK122639, AK313684, AL356486, DB204461
      Consensus CDS
      CCDS9482.1
      UniProtKB/Swiss-Prot
      Q5T5A7, Q86TL1, Q96P68
      UniProtKB/TrEMBL
      B2R986
      Related
      ENSP00000445269.2, ENST00000541518.6
      Conserved Domains (1) summary
      cd15375
      Location:34313
      7tmA_OXGR1; 2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    5. NM_080818.5NP_543008.3  2-oxoglutarate receptor 1

      See identical proteins and their annotated locations for NP_543008.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AK122639, AL356486, DN993601
      Consensus CDS
      CCDS9482.1
      UniProtKB/Swiss-Prot
      Q5T5A7, Q86TL1, Q96P68
      UniProtKB/TrEMBL
      B2R986
      Related
      ENSP00000298440.1, ENST00000298440.5
      Conserved Domains (1) summary
      cd15375
      Location:34313
      7tmA_OXGR1; 2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      96985713..96994730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430274.1XP_047286230.1  2-oxoglutarate receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T5A7, Q86TL1, Q96P68
      UniProtKB/TrEMBL
      B2R986

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      96189803..96198827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374465.1XP_054230440.1  2-oxoglutarate receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T5A7, Q86TL1, Q96P68
      UniProtKB/TrEMBL
      B2R986
    2. XM_054374464.1XP_054230439.1  2-oxoglutarate receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T5A7, Q86TL1, Q96P68
      UniProtKB/TrEMBL
      B2R986