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    POLL DNA polymerase lambda [ Homo sapiens (human) ]

    Gene ID: 27343, updated on 10-Dec-2024

    Summary

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    Official Symbol
    POLLprovided by HGNC
    Official Full Name
    DNA polymerase lambdaprovided by HGNC
    Primary source
    HGNC:HGNC:9184
    See related
    Ensembl:ENSG00000166169 MIM:606343; AllianceGenome:HGNC:9184
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BETAN; POLKAPPA
    Summary
    This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010]
    Expression
    Ubiquitous expression in testis (RPKM 14.9), ovary (RPKM 7.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See POLL in Genome Data Viewer
    Location:
    10q24.32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (101578882..101588270, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (102462924..102472307, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103338639..103348027, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene RNA, U2 small nuclear 59, pseudogene Neighboring gene beta-transducin repeat containing E3 ubiquitin protein ligase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103201016-103201516 Neighboring gene VISTA enhancer hs326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103320958-103321458 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3913 Neighboring gene NANOG hESC enhancer GRCh37_chr10:103356755-103357323 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2722 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:103367960-103368675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103371133-103371633 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103372791-103373324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103373325-103373858 Neighboring gene microRNA 3158-1 Neighboring gene microRNA 3158-2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103378239-103379151 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103379197-103379698 Neighboring gene deleted in primary ciliary dyskinesia homolog (mouse) Neighboring gene RNA, U6 small nuclear 1165, pseudogene Neighboring gene F-box and WD repeat domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Kinetic effect of a downstream strand and its 5'-terminal moieties on single nucleotide gap-filling synthesis catalyzed by human DNA polymerase lambda. Duym WW, et al. J Biol Chem, 2006 Nov 24. PMID 17005572
    2. Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint. Zucca E, et al. Nucleic Acids Res, 2013 Jan 7. PMID 23118481, Free PMC Article
    3. The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1. Maga G, et al. FASEB J, 2004 Nov. PMID 15358682
    4. DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A. Maga G, et al. J Biol Chem, 2005 Jan 21. PMID 15537631
    5. Human DNA polymerase λ catalyzes lesion bypass across benzo[a]pyrene-derived DNA adduct during base excision repair. Skosareva LV, et al. DNA Repair (Amst), 2012 Apr 1. PMID 22317757

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sustained pigmentation causes DNA damage and invokes translesion polymerase Polkappa for repair in melanocytes.
      Title: Sustained pigmentation causes DNA damage and invokes translesion polymerase Polκ for repair in melanocytes.
    2. A Role for Human DNA Polymerase lambda in Alternative Lengthening of Telomeres.
      Title: A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres.
    3. PAXX, XLF and XRCC4 synergise in the efficient DNA double-strand breaks recruitment, substrate recognition and stimulation of Pol lambda enzymatic activity during nonhomologous end joining DNA repair.
      Title: PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair.
    4. Bond formation and cleavage reactions catalyzed by base excision repair DNA polymerases beta and lambda has been described.
      Title: Uniform Free-Energy Profiles of the P-O Bond Formation and Cleavage Reactions Catalyzed by DNA Polymerases β and λ.
    5. When mutated or deregulated, DNA polymerase lambda can also be a source of genetic instability. Its multiple roles in DNA damage tolerance and its ability in promoting tumor progression make it also a possible target for novel anticancer approaches. [review]
      Title: Living on the Edge: DNA Polymerase Lambda between Genome Stability and Mutagenesis.
    6. Data suggest that individuals who carry the rs3730477 POLL germline variant have an increased risk of estrogen-associated breast cancer.
      Title: Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein.
    7. T204 was identified as a main target for ATM/DNA-PKcs phosphorylation on human POLL, and this phosphorylation may facilitate the repair of a subset of IR-induced DSBs and the efficient POLL-mediated gap-filling during NHEJ. POLL phosphorylation might favor POLL interaction with the DNA-PK complex at DSBs.
      Title: Regulation of human polλ by ATM-mediated phosphorylation during non-homologous end joining.
    8. The authors demonstrate that Pol lambda has a flexible active site that can tolerate 8-oxo-dG in either the anti- or syn-conformation. Importantly, we show that discrimination against the pro-mutagenic syn-conformation occurs at the extension step and identify the residue responsible for this selectivity.
      Title: A fidelity mechanism in DNA polymerase lambda promotes error-free bypass of 8-oxo-dG.
    9. Pol beta, to a greater extent than Pol lambda can incorporate rNMPs opposite normal bases or 8-oxo-G, and with a different fidelity. Further, the incorporation of rNMPs opposite 8-oxo-G delays repair by DNA glycosylases.
      Title: Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair.
    10. Fen1 significantly stimulated trinucleotide repeats expansion by Pol beta, but not by the related enzyme Pol lambda.
      Title: Expansion of CAG triplet repeats by human DNA polymerases λ and β in vitro, is regulated by flap endonuclease 1 and DNA ligase 1.
    Submit: New GeneRIF Correction See all GeneRIFs (65)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2011-12-21)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2011-12-21)

    ClinGen Genome Curation Page

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ46002

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 5'-deoxyribose-5-phosphate lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed DNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity TAS
    Traceable Author Statement
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA replication NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in base-excision repair, gap-filling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining TAS
    Traceable Author Statement
    more info
    		  
    involved_in nucleotide-excision repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in somatic hypermutation of immunoglobulin genes NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase lambda
    Names
    DNA polymerase beta-2
    DNA polymerase beta-N
    DNA polymerase kappa
    polymerase (DNA directed), lambda
    polymerase (DNA) lambda
    NP_001167555.1
    NP_001167556.1
    NP_001295311.1
    NP_037406.1
    XP_006717838.1
    XP_006717840.1
    XP_011537952.1
    XP_011537953.1
    XP_011537956.1
    XP_011537957.1
    XP_011537958.1
    XP_011537959.1
    XP_011537964.1
    XP_011537966.1
    XP_016871573.1
    XP_016871574.1
    XP_016871577.1
    XP_016871579.1
    XP_016871580.1
    XP_024303710.1
    XP_024303711.1
    XP_024303713.2
    XP_047281042.1
    XP_047281043.1
    XP_047281044.1
    XP_047281045.1
    XP_047281046.1
    XP_047281047.1
    XP_047281048.1
    XP_047281049.1
    XP_047281050.1
    XP_047281051.1
    XP_047281052.1
    XP_047281053.1
    XP_047281054.1
    XP_054221561.1
    XP_054221562.1
    XP_054221563.1
    XP_054221564.1
    XP_054221565.1
    XP_054221566.1
    XP_054221567.1
    XP_054221568.1
    XP_054221569.1
    XP_054221570.1
    XP_054221571.1
    XP_054221572.1
    XP_054221573.1
    XP_054221574.1
    XP_054221575.1
    XP_054221576.1
    XP_054221577.1
    XP_054221578.1
    XP_054221579.1
    XP_054221580.1
    XP_054221581.1
    XP_054221582.1
    XP_054221583.1
    XP_054221584.1
    XP_054221585.1
    XP_054221586.1
    XP_054221587.1
    XP_054221588.1
    XP_054221589.1
    XP_054221590.1
    XP_054221591.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017063.1 RefSeqGene

      Range
      5014..14389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001174084.2 → NP_001167555.1  DNA polymerase lambda isoform a

      See identical proteins and their annotated locations for NP_001167555.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AJ131890, BC068529, DC296090
      Consensus CDS
      CCDS7513.1
      UniProtKB/Swiss-Prot
      D3DR76, Q5JQP5, Q6NUM2, Q9BTN8, Q9HA10, Q9HB35, Q9UGP5
      UniProtKB/TrEMBL
      Q9HAJ3
      Related
      ENSP00000359181.3, ENST00000370162.8
      Conserved Domains (2) summary
      cd00141
      Location:255 → 573
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      smart00483
      Location:251 → 574
      POLXc; DNA polymerase X family

    2. NM_001174085.2 → NP_001167556.1  DNA polymerase lambda isoform b

      See identical proteins and their annotated locations for NP_001167556.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform b, also known as lambda2), compared to isoform a.
      Source sequence(s)
      AK292225, BC068529, DC409528
      UniProtKB/TrEMBL
      A8K860, Q5QJV5
      Conserved Domains (1) summary
      cd00141
      Location:202 → 481
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

    3. NM_001308382.2 → NP_001295311.1  DNA polymerase lambda isoform c

      See identical proteins and their annotated locations for NP_001295311.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks three exons in the 5' coding region, compared to variant 1. This results in the use of an alternate start codon and a frameshifted 5' coding region. The encoded isoform (c) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AF161019, BI906881, DA107389
      Consensus CDS
      CCDS76332.1
      UniProtKB/TrEMBL
      Q5JQP4
      Related
      ENSP00000485885.1, ENST00000628479.2
      Conserved Domains (1) summary
      cd00141
      Location:22 → 298
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

    4. NM_013274.4 → NP_037406.1  DNA polymerase lambda isoform a

      See identical proteins and their annotated locations for NP_037406.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AJ131890, BC068529, DC409528
      Consensus CDS
      CCDS7513.1
      UniProtKB/Swiss-Prot
      D3DR76, Q5JQP5, Q6NUM2, Q9BTN8, Q9HA10, Q9HB35, Q9UGP5
      UniProtKB/TrEMBL
      Q9HAJ3
      Related
      ENSP00000299206.4, ENST00000299206.8
      Conserved Domains (2) summary
      cd00141
      Location:255 → 573
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      smart00483
      Location:251 → 574
      POLXc; DNA polymerase X family

    RNA

    1. NR_033406.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AK022476, BC068529, DC379162

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      101578882..101588270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425090.1 → XP_047281046.1  DNA polymerase lambda isoform X15

      UniProtKB/TrEMBL
      Q5QJV5

    2. XM_047425094.1 → XP_047281050.1  DNA polymerase lambda isoform X19

    3. XM_047425092.1 → XP_047281048.1  DNA polymerase lambda isoform X17

    4. XM_047425088.1 → XP_047281044.1  DNA polymerase lambda isoform X10

      UniProtKB/TrEMBL
      Q5JQP8, Q9HAJ3
      Related
      ENSP00000359191.1, ENST00000370172.5

    5. XM_047425087.1 → XP_047281043.1  DNA polymerase lambda isoform X9

      UniProtKB/TrEMBL
      Q9HAJ3

    6. XM_024447945.2 → XP_024303713.2  DNA polymerase lambda isoform X23

      UniProtKB/TrEMBL
      B3KXT3, B4DE17

    7. XM_017016090.2 → XP_016871579.1  DNA polymerase lambda isoform X13

      Conserved Domains (1) summary
      cl00038
      Location:61 → 127
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

    8. XM_017016088.3 → XP_016871577.1  DNA polymerase lambda isoform X11

      Conserved Domains (1) summary
      cl00038
      Location:61 → 127
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

    9. XM_047425086.1 → XP_047281042.1  DNA polymerase lambda isoform X8

      UniProtKB/TrEMBL
      Q5QJV5

    10. XM_011539656.2 → XP_011537958.1  DNA polymerase lambda isoform X6

      UniProtKB/TrEMBL
      Q5QJV5
      Conserved Domains (1) summary
      cd00141
      Location:188 → 474
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

    11. XM_011539655.2 → XP_011537957.1  DNA polymerase lambda isoform X4

      See identical proteins and their annotated locations for XP_011537957.1

      UniProtKB/TrEMBL
      A8K860, Q5QJV5
      Conserved Domains (1) summary
      cd00141
      Location:202 → 481
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

    12. XM_011539654.2 → XP_011537956.1  DNA polymerase lambda isoform X3

      UniProtKB/TrEMBL
      Q5QJV5
      Related
      ENSP00000400676.1, ENST00000415897.5
      Conserved Domains (1) summary
      cd00141
      Location:202 → 488
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

    13. XM_017016085.2 → XP_016871574.1  DNA polymerase lambda isoform X7

    14. XM_017016084.2 → XP_016871573.1  DNA polymerase lambda isoform X5

    15. XM_011539651.2 → XP_011537953.1  DNA polymerase lambda isoform X2

      See identical proteins and their annotated locations for XP_011537953.1

      UniProtKB/Swiss-Prot
      D3DR76, Q5JQP5, Q6NUM2, Q9BTN8, Q9HA10, Q9HB35, Q9UGP5
      UniProtKB/TrEMBL
      Q9HAJ3
      Related
      ENSP00000359188.1, ENST00000370169.5
      Conserved Domains (2) summary
      cd00141
      Location:255 → 573
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      smart00483
      Location:251 → 574
      POLXc; DNA polymerase X family

    16. XM_011539650.2 → XP_011537952.1  DNA polymerase lambda isoform X1

      See identical proteins and their annotated locations for XP_011537952.1

      UniProtKB/TrEMBL
      Q9HAJ3
      Conserved Domains (2) summary
      cd00141
      Location:255 → 580
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      smart00483
      Location:251 → 581
      POLXc; DNA polymerase X family

    17. XM_011539657.2 → XP_011537959.1  DNA polymerase lambda isoform X9

      See identical proteins and their annotated locations for XP_011537959.1

      UniProtKB/TrEMBL
      Q9HAJ3
      Conserved Domains (1) summary
      cd00141
      Location:167 → 492
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

    18. XM_047425095.1 → XP_047281051.1  DNA polymerase lambda isoform X20

    19. XM_047425093.1 → XP_047281049.1  DNA polymerase lambda isoform X18

    20. XM_047425091.1 → XP_047281047.1  DNA polymerase lambda isoform X16

      UniProtKB/TrEMBL
      Q5QJV5

    21. XM_024447943.2 → XP_024303711.1  DNA polymerase lambda isoform X10

      UniProtKB/TrEMBL
      Q5JQP8, Q9HAJ3
      Conserved Domains (1) summary
      cd00141
      Location:167 → 485
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

    22. XM_024447942.2 → XP_024303710.1  DNA polymerase lambda isoform X9

      UniProtKB/TrEMBL
      Q9HAJ3
      Conserved Domains (1) summary
      cd00141
      Location:167 → 492
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

    23. XM_006717777.3 → XP_006717840.1  DNA polymerase lambda isoform X28

      See identical proteins and their annotated locations for XP_006717840.1

      UniProtKB/TrEMBL
      Q5JQP4
      Related
      ENSP00000343102.3, ENST00000339310.7
      Conserved Domains (1) summary
      cd00141
      Location:22 → 298
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

    24. XM_011539664.3 → XP_011537966.1  DNA polymerase lambda isoform X26

      See identical proteins and their annotated locations for XP_011537966.1

      UniProtKB/TrEMBL
      Q5JQP4
      Conserved Domains (1) summary
      cd00141
      Location:22 → 305
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

    25. XM_006717775.3 → XP_006717838.1  DNA polymerase lambda isoform X25

      See identical proteins and their annotated locations for XP_006717838.1

      UniProtKB/TrEMBL
      B4DEF5
      Conserved Domains (1) summary
      cd00141
      Location:33 → 312
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

    26. XM_011539662.3 → XP_011537964.1  DNA polymerase lambda isoform X24

      See identical proteins and their annotated locations for XP_011537964.1

      UniProtKB/TrEMBL
      B4DEF5
      Conserved Domains (1) summary
      cd00141
      Location:33 → 319
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases

    27. XM_017016091.3 → XP_016871580.1  DNA polymerase lambda isoform X14

    28. XM_047425089.1 → XP_047281045.1  DNA polymerase lambda isoform X12

    29. XM_047425098.1 → XP_047281054.1  DNA polymerase lambda isoform X27

    30. XM_047425096.1 → XP_047281052.1  DNA polymerase lambda isoform X21

      Related
      ENSP00000400517.1, ENST00000413344.5

    31. XM_047425097.1 → XP_047281053.1  DNA polymerase lambda isoform X22

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      102462924..102472307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365603.1 → XP_054221578.1  DNA polymerase lambda isoform X15

      UniProtKB/TrEMBL
      Q5QJV5

    2. XM_054365607.1 → XP_054221582.1  DNA polymerase lambda isoform X19

    3. XM_054365605.1 → XP_054221580.1  DNA polymerase lambda isoform X17

    4. XM_054365598.1 → XP_054221573.1  DNA polymerase lambda isoform X10

      UniProtKB/TrEMBL
      Q9HAJ3

    5. XM_054365595.1 → XP_054221570.1  DNA polymerase lambda isoform X9

      UniProtKB/TrEMBL
      Q9HAJ3

    6. XM_054365611.1 → XP_054221586.1  DNA polymerase lambda isoform X23

      UniProtKB/TrEMBL
      B3KXT3, B4DE17

    7. XM_054365601.1 → XP_054221576.1  DNA polymerase lambda isoform X13

    8. XM_054365599.1 → XP_054221574.1  DNA polymerase lambda isoform X11

    9. XM_054365593.1 → XP_054221568.1  DNA polymerase lambda isoform X8

      UniProtKB/TrEMBL
      Q5QJV5

    10. XM_054365591.1 → XP_054221566.1  DNA polymerase lambda isoform X6

      UniProtKB/TrEMBL
      Q5QJV5

    11. XM_054365589.1 → XP_054221564.1  DNA polymerase lambda isoform X4

      UniProtKB/TrEMBL
      A8K860, Q5QJV5

    12. XM_054365588.1 → XP_054221563.1  DNA polymerase lambda isoform X3

      UniProtKB/TrEMBL
      Q5QJV5

    13. XM_054365592.1 → XP_054221567.1  DNA polymerase lambda isoform X7

    14. XM_054365590.1 → XP_054221565.1  DNA polymerase lambda isoform X5

    15. XM_054365587.1 → XP_054221562.1  DNA polymerase lambda isoform X2

      UniProtKB/TrEMBL
      Q9HAJ3

    16. XM_054365586.1 → XP_054221561.1  DNA polymerase lambda isoform X1

      UniProtKB/TrEMBL
      Q9HAJ3

    17. XM_054365596.1 → XP_054221571.1  DNA polymerase lambda isoform X9

      UniProtKB/TrEMBL
      Q9HAJ3

    18. XM_054365608.1 → XP_054221583.1  DNA polymerase lambda isoform X20

    19. XM_054365606.1 → XP_054221581.1  DNA polymerase lambda isoform X18

    20. XM_054365604.1 → XP_054221579.1  DNA polymerase lambda isoform X16

      UniProtKB/TrEMBL
      Q5QJV5

    21. XM_054365597.1 → XP_054221572.1  DNA polymerase lambda isoform X10

      UniProtKB/TrEMBL
      Q9HAJ3

    22. XM_054365594.1 → XP_054221569.1  DNA polymerase lambda isoform X9

      UniProtKB/TrEMBL
      Q9HAJ3

    23. XM_054365616.1 → XP_054221591.1  DNA polymerase lambda isoform X28

      UniProtKB/TrEMBL
      Q5JQP4

    24. XM_054365614.1 → XP_054221589.1  DNA polymerase lambda isoform X26

      UniProtKB/TrEMBL
      Q5JQP4

    25. XM_054365613.1 → XP_054221588.1  DNA polymerase lambda isoform X25

      UniProtKB/TrEMBL
      B4DEF5

    26. XM_054365612.1 → XP_054221587.1  DNA polymerase lambda isoform X24

      UniProtKB/TrEMBL
      B4DEF5

    27. XM_054365602.1 → XP_054221577.1  DNA polymerase lambda isoform X14

    28. XM_054365600.1 → XP_054221575.1  DNA polymerase lambda isoform X12

    29. XM_054365615.1 → XP_054221590.1  DNA polymerase lambda isoform X27

    30. XM_054365609.1 → XP_054221584.1  DNA polymerase lambda isoform X21

    31. XM_054365610.1 → XP_054221585.1  DNA polymerase lambda isoform X22

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UGP5.1 GenPept UniProtKB/Swiss-Prot:Q9UGP5

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