Cdk12 cyclin dependent kinase 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdk12provided by MGI
Official Full Name: cyclin dependent kinase 12provided by MGI
Primary source: MGI:MGI:1098802
See related: Ensembl:ENSMUSG00000003119 AllianceGenome:MGI:1098802
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crk7; Pksc; Crkrs; D11Ertd752e; 1810022J16Rik
Summary: Enables protein kinase binding activity. Acts upstream of or within negative regulation of stem cell differentiation. Predicted to be located in nuclear speck. Predicted to be part of cyclin K-CDK12 complex and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in several structures, including blastocyst; early embryo; future brain; primitive streak; and unsegmented mesenchyme. Orthologous to human CDK12 (cyclin dependent kinase 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 3.5), limb E14.5 (RPKM 3.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 61.75 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (98093259..98171941)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (98202433..98281101)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidney injury through transcriptional elongation defects.
Title: Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidney injury through transcriptional elongation defects.
Cyclin-dependent kinase 12 deficiency reprogrammes cellular metabolism to alleviate ferroptosis potential and promote the progression of castration-resistant prostate cancer.
Title: Cyclin-dependent kinase 12 deficiency reprogrammes cellular metabolism to alleviate ferroptosis potential and promote the progression of castration-resistant prostate cancer.
Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/beta-catenin signaling pathway.
Title: Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/β-catenin signaling pathway.
The mechanism of BUD13 m6A methylation mediated MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry in glioblastoma cells.
Title: The mechanism of BUD13 m6A methylation mediated MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry in glioblastoma cells.
Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer.
Title: Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer.
Tubular-specific CDK12 knockout causes a defect in urine concentration due to premature cleavage of the slc12a1 gene.
Title: Tubular-specific CDK12 knockout causes a defect in urine concentration due to premature cleavage of the slc12a1 gene.
CDK12 regulates DNA repair genes by suppressing intronic polyadenylation; work clarifies the function of CDK12 and underscores its potential both as a chemotherapeutic target and as a tumour biomarker
Title: CDK12 regulates DNA repair genes by suppressing intronic polyadenylation.
Spontaneous DNA damage was revealed by an increase in 53BP1 foci among cells cultured from Cdk12(-/-) embryos.
Title: Cdk12 is essential for embryonic development and the maintenance of genomic stability.
Report on the functions of Cdk12 during neural development in vivo, proposes a dual role for Cdk12 in neurogenesis and late stage neuronal migration via 2 distinct pathways
Title: Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex.
The findings of this study suggest that Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.
Title: Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI646528 (e-PCR)
- UniSTS:180316

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

D11Ertd752e (e-PCR), detects polymorphism
- UniSTS:167079

NoName (e-PCR)
- UniSTS:236726

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cyclin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin binding	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in RNA splicing	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cyclin K-CDK12 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin/CDK positive transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
part_of nuclear cyclin-dependent protein kinase holoenzyme complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cyclin-dependent kinase 12

Names: CDC2-related kinase 7; CDC2-related kinase, arginine/serine-rich; CDC2-related protein kinase 7; cell division cycle 2-related protein kinase 7; cell division protein kinase 12; protein kinase for splicing component

NP_001103096.1

EC 2.7.11.22

EC 2.7.11.23

NP_001103098.1

EC 2.7.11.22

EC 2.7.11.23

NP_081228.2

EC 2.7.11.22

EC 2.7.11.23

XP_006534171.1

EC 2.7.11.22

EC 2.7.11.23

XP_011247527.1

EC 2.7.11.22

EC 2.7.11.23

XP_030102133.1

EC 2.7.11.22

EC 2.7.11.23

XP_030102134.1

EC 2.7.11.22

EC 2.7.11.23

XP_030102135.1

EC 2.7.11.22

EC 2.7.11.23

XP_036012845.1

EC 2.7.11.22

EC 2.7.11.23

XP_036012846.1

EC 2.7.11.22

EC 2.7.11.23

XP_036012848.1

EC 2.7.11.22

EC 2.7.11.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109626.1 → NP_001103096.1 cyclin-dependent kinase 12 isoform 1

See identical proteins and their annotated locations for NP_001103096.1

Status: VALIDATED

Source sequence(s)

AA066711, AK049376, AL591205, BC116645

Consensus CDS

CCDS48901.1

UniProtKB/Swiss-Prot

A2A530, A2A531, B1AQH7, Q14AX6, Q6ZQ27, Q8R457

Related

ENSMUSP00000103162.2, ENSMUST00000107538.2

Conserved Domains (1) summary

cd07864
Location:715 → 1016

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
NM_001109628.1 → NP_001103098.1 cyclin-dependent kinase 12 isoform 2

Status: VALIDATED

Source sequence(s)

AA066711, AK129237, AL591205, BC116645

Consensus CDS

CCDS48902.1

UniProtKB/Swiss-Prot

Q14AX6

Related

ENSMUSP00000103163.2, ENSMUST00000107539.8

Conserved Domains (1) summary

cd07864
Location:715 → 1016

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
NM_026952.2 → NP_081228.2 cyclin-dependent kinase 12 isoform 3

See identical proteins and their annotated locations for NP_081228.2

Status: VALIDATED

Source sequence(s)

AA066711, AL591205, BC116645

Consensus CDS

CCDS25342.1

UniProtKB/Swiss-Prot

Q14AX6

Related

ENSMUSP00000003203.8, ENSMUST00000003203.14

Conserved Domains (2) summary

smart00220
Location:723 → 1016

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07864
Location:715 → 1016

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

RNA

NR_175406.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL591205
NR_175407.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL591205
NR_175408.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL591205
NR_175409.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL591205
NR_175478.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL591205

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

98093259..98171941

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246273.1 → XP_030102133.1 cyclin-dependent kinase 12 isoform X1

UniProtKB/Swiss-Prot

A2A530, A2A531, B1AQH7, Q14AX6, Q6ZQ27, Q8R457

Conserved Domains (1) summary

cd07864
Location:715 → 1016

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_006534108.4 → XP_006534171.1 cyclin-dependent kinase 12 isoform X2

Conserved Domains (1) summary

cd07864
Location:714 → 1015

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_036156952.1 → XP_036012845.1 cyclin-dependent kinase 12 isoform X4

Conserved Domains (1) summary

cd07864
Location:714 → 1015

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_011249225.4 → XP_011247527.1 cyclin-dependent kinase 12 isoform X10

See identical proteins and their annotated locations for XP_011247527.1

Conserved Domains (1) summary

cd07864
Location:715 → 1016

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_036156955.1 → XP_036012848.1 cyclin-dependent kinase 12 isoform X9

Conserved Domains (2) summary

PRK08691
Location:1136 → 1313

PRK08691; DNA polymerase III subunits gamma and tau; Validated

cd07864
Location:715 → 997

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_030246274.2 → XP_030102134.1 cyclin-dependent kinase 12 isoform X1

UniProtKB/Swiss-Prot

A2A530, A2A531, B1AQH7, Q14AX6, Q6ZQ27, Q8R457

Conserved Domains (1) summary

cd07864
Location:715 → 1016

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_030246275.2 → XP_030102135.1 cyclin-dependent kinase 12 isoform X3

Conserved Domains (1) summary

cd07864
Location:715 → 1016

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_036156953.1 → XP_036012846.1 cyclin-dependent kinase 12 isoform X5

Conserved Domains (1) summary

cd07864
Location:715 → 997

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12