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    Arf1 ADP ribosylation factor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40506, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Arf1provided by FlyBase
    Official Full Name
    ADP ribosylation factor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0010348
    Locus tag
    Dmel_CG8385
    See related
    AllianceGenome:FB:FBgn0010348
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Arf; ARF-1; arf1; ARF1; ARF1_DROME; Arf79; Arf79f; Arf79F; CG8385; d-Arf1; dArf1; Darf1; dArf79F; dARF79F; dARFI; Dm Arf79F; Dmel\CG8385; P61209
    Summary
    Enables GTPase activity. Involved in several processes, including ARF protein signal transduction; Golgi to plasma membrane protein transport; and cytoskeleton-dependent cytokinesis. Acts upstream of with a positive effect on imaginal disc-derived wing morphogenesis. Located in several cellular components, including Golgi stack; cleavage furrow; and lysosome. Colocalizes with intracellular membrane-bounded organelle. Is expressed in several structures, including adult head; adult heart; embryonic/larval lymph gland; and hemocyte. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to several human genes including ARF1 (ADP ribosylation factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Arf1 in Genome Data Viewer
    Location:
    80B1-80B1; 3-47 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22868380..22872231, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22861480..22865331, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ER membrane protein complex subunit 4 Neighboring gene antisense RNA:CR45969 Neighboring gene antisense RNA:CR45968 Neighboring gene uncharacterized protein Neighboring gene Chromator Neighboring gene antisense RNA:CR45970 Neighboring gene Suppressor of stem-loop mutation

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a conserved, guanine nucleotide-dependent ADP-ribosylation factor in Drosophila melanogaster. Murtagh JJ Jr, et al. Biochemistry, 1993 Jun 15. PMID 8507638
    2. Intron "sliding" and the diversity of intron positions. Stoltzfus A, et al. Proc Natl Acad Sci U S A, 1997 Sep 30. PMID 9380704, Free PMC Article
    3. Expression, Purification and Crystallization of Asrij, A Novel Scaffold Transmembrane Protein. Motiwala Z, et al. J Membr Biol, 2021 Feb. PMID 33433647
    4. SnoRNA U21 is also intron-encoded in Drosophila melanogaster but in a different host-gene as compared to warm-blooded vertebrates. Renalier MH, et al. FEBS Lett, 1996 Feb 5. PMID 8603691
    5. Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting. Wilfling F, et al. Elife, 2014. PMID 24497546, Free PMC Article

    See all (141) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that in addition to its requirement in hematopoiesis, the ARF1-Asrij axis can differentially regulate humoral immunity in Drosophila, most likely by virtue of its endosomal function. ARF1 and Asrij bring about differential endocytic modulation of immune pathways and their depletion leads to aberrant pathway activity and an immune imbalance.
      Title: Differential modulation of the cellular and humoral immune responses in Drosophila is mediated by the endosomal ARF1-Asrij axis.
    2. Identification of Sec71 as a guanine nucleotide exchange factor for Arf1 that preferentially interacts with its GDP-bound form. Like Arf1, Sec71 is also important for dendrite pruning, but not for apoptosis of sensory neurons.
      Title: Sec71 functions as a GEF for the small GTPase Arf1 to govern dendrite pruning of Drosophila sensory neurons.
    3. Suggest a model in which Arf1/COPI machinery acts to control endoplasmic reticulum-lipid droplet connections for localization of key enzymes of triglyceride storage and catabolism.
      Title: Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting.
    4. ARF1-Asrij endocytic axis modulates signals that govern hematopoietic development.
      Title: ARF1-GTP regulates Asrij to provide endocytic control of Drosophila blood cell homeostasis.
    5. Sata indicate that the Class I Arf GTPase is a central component in WRC-driven lamellipodium formation.
      Title: The Drosophila Arf1 homologue Arf79F is essential for lamellipodium formation.
    6. Results suggest that N-cadherin is regulated in a Schizo/Loner- and d-Arf1-dependent manner.
      Title: The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ARF protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Golgi to plasma membrane protein transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect imaginal disc-derived wing morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male meiosis cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cleavage furrow ingression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter secretion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron remodeling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of antibacterial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lipid storage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP ribosylation factor 1
    Names
    ADP ribosylation factor 79F
    ADP ribosylation factor at 79F
    ADP-ribosylation factor 1
    Arf1-PA
    Arf1-PB
    Arf1-PC
    Arf1-PE
    Arf1-PF
    Arf1-PH
    Arf1-PI
    Arf1-PJ
    CG8385-PA
    CG8385-PB
    CG8385-PC
    CG8385-PE
    CG8385-PF
    CG8385-PH
    CG8385-PI
    CG8385-PJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22868380..22872231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168972.5 → NP_730759.1  ADP ribosylation factor 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730759.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2B1, A8JNX4, P35676, P61209, Q9VNQ2
      UniProtKB/TrEMBL
      M9PG22
      Related
      FBpp0289184
      Conserved Domains (1) summary
      smart00177
      Location:5 → 179
      ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

    2. NM_001104198.2 → NP_001097668.2  ADP ribosylation factor 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097668.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2B1, A8JNX4, P35676, P61209, Q9VNQ2
      UniProtKB/TrEMBL
      M9PG22
      Conserved Domains (1) summary
      smart00177
      Location:5 → 179
      ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

    3. NM_168970.4 → NP_730757.1  ADP ribosylation factor 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730757.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2B1, A8JNX4, P35676, P61209, Q9VNQ2
      UniProtKB/TrEMBL
      M9PG22
      Related
      FBpp0078222
      Conserved Domains (1) summary
      smart00177
      Location:5 → 179
      ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

    4. NM_001104197.3 → NP_001097667.1  ADP ribosylation factor 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097667.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2B1, A8JNX4, P35676, P61209, Q9VNQ2
      UniProtKB/TrEMBL
      M9PG22
      Conserved Domains (1) summary
      smart00177
      Location:5 → 179
      ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

    5. NM_001275296.1 → NP_001262225.1  ADP ribosylation factor 1, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262225.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2B1, A8JNX4, P35676, P61209, Q9VNQ2
      UniProtKB/TrEMBL
      M9PG22
      Conserved Domains (1) summary
      smart00177
      Location:5 → 179
      ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

    6. NM_057607.6 → NP_476955.1  ADP ribosylation factor 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476955.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2B1, A8JNX4, P35676, P61209, Q9VNQ2
      UniProtKB/TrEMBL
      M9PG22
      Related
      FBpp0078224
      Conserved Domains (1) summary
      smart00177
      Location:5 → 179
      ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

    7. NM_168973.3 → NP_730760.1  ADP ribosylation factor 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730760.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2B1, A8JNX4, P35676, P61209, Q9VNQ2
      UniProtKB/TrEMBL
      M9PG22
      Related
      FBpp0078225
      Conserved Domains (1) summary
      smart00177
      Location:5 → 179
      ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

    8. NM_168971.4 → NP_730758.1  ADP ribosylation factor 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730758.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2B1, A8JNX4, P35676, P61209, Q9VNQ2
      UniProtKB/TrEMBL
      M9PG22
      Related
      FBpp0078226
      Conserved Domains (1) summary
      smart00177
      Location:5 → 179
      ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PG22 M9PG22
    P61209.2 P61209

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