Mast3 microtubule associated serine/threonine kinase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mast3provided by MGI
Official Full Name: microtubule associated serine/threonine kinase 3provided by MGI
Primary source: MGI:MGI:2683541
See related: Ensembl:ENSMUSG00000031833 AllianceGenome:MGI:2683541
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0561
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cytoskeleton organization and intracellular signal transduction. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 108. Orthologous to human MAST3 (microtubule associated serine/threonine kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in thymus adult (RPKM 51.9), cortex adult (RPKM 30.0) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.15 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (71230761..71257681, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (70778117..70805048, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We describe a novel mechanism of signal transduction enriched in medium spiny neurons of striatum that likely mediates effects of the neurotransmitter dopamine acting on these cells. We find that the protein ARPP-16, which is highly expressed in striatal medium spiny neurons, acts as a selective inhibitor of certain forms of the serine/threonine protein phosphatase, PP2A, when phosphorylated by the kinase, MAST3.
Title: ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase).
As in human immune cells, murine Mast3 is constitutively expressed in CD4-positive and CD8-positive T cells and CD19-expressing B cells.
Title: MAST3: a novel IBD risk factor that modulates TLR4 signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: microtubule-associated serine/threonine-protein kinase 3

NP_001389902.1

EC 2.7.11.1

NP_001389903.1

EC 2.7.11.1

NP_001389904.1

EC 2.7.11.1

NP_001389905.1

EC 2.7.11.1

NP_001389907.1

EC 2.7.11.1

NP_001389908.1

EC 2.7.11.1

NP_001389909.1

EC 2.7.11.1

NP_955012.2

EC 2.7.11.1

XP_006509771.2

EC 2.7.11.1

XP_006509772.2

EC 2.7.11.1

XP_006509773.2

EC 2.7.11.1

XP_006509775.1

EC 2.7.11.1

XP_017168397.2

EC 2.7.11.1

XP_017168398.1

EC 2.7.11.1

XP_036010079.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001402973.1 → NP_001389902.1 microtubule-associated serine/threonine-protein kinase 3 isoform 1

Status: VALIDATED

Source sequence(s)

AC162446
NM_001402974.1 → NP_001389903.1 microtubule-associated serine/threonine-protein kinase 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC162446

UniProtKB/Swiss-Prot

E9QQ28, Q3U214, Q6A047

Related

ENSMUSP00000128703.3, ENSMUST00000166004.3
NM_001402975.1 → NP_001389904.1 microtubule-associated serine/threonine-protein kinase 3 isoform 3

Status: VALIDATED

Source sequence(s)

AC162446
NM_001402976.1 → NP_001389905.1 microtubule-associated serine/threonine-protein kinase 3 isoform 4

Status: VALIDATED

Source sequence(s)

AC162446
NM_001402978.1 → NP_001389907.1 microtubule-associated serine/threonine-protein kinase 3 isoform 6

Status: VALIDATED

Source sequence(s)

AC162446
NM_001402979.1 → NP_001389908.1 microtubule-associated serine/threonine-protein kinase 3 isoform 7

Status: VALIDATED

Source sequence(s)

AC162446
NM_001402980.1 → NP_001389909.1 microtubule-associated serine/threonine-protein kinase 3 isoform 8

Status: VALIDATED

Source sequence(s)

AC162446
NM_199308.3 → NP_955012.2 microtubule-associated serine/threonine-protein kinase 3 isoform 5

Status: VALIDATED

Source sequence(s)

AC162446

Consensus CDS

CCDS52577.1

UniProtKB/TrEMBL

A0A1D5RM97

Related

ENSMUSP00000148686.2, ENSMUST00000211948.2

Conserved Domains (4) summary

smart00220
Location:373 → 646

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:955 → 1032

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:372 → 651

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:64 → 337

DUF1908; Domain of unknown function (DUF1908)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

71230761..71257681 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154186.1 → XP_036010079.1 microtubule-associated serine/threonine-protein kinase 3 isoform X11

Conserved Domains (3) summary

cd00992
Location:955 → 1032

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:372 → 651

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:57 → 337

DUF1908; Domain of unknown function (DUF1908)
XM_017312908.2 → XP_017168397.2 microtubule-associated serine/threonine-protein kinase 3 isoform X10

Conserved Domains (3) summary

cd00992
Location:956 → 1033

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:373 → 652

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:58 → 338

DUF1908; Domain of unknown function (DUF1908)
XM_006509710.3 → XP_006509773.2 microtubule-associated serine/threonine-protein kinase 3 isoform X5

Conserved Domains (3) summary

cd00992
Location:978 → 1055

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:395 → 674

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:87 → 360

DUF1908; Domain of unknown function (DUF1908)
XM_006509708.3 → XP_006509771.2 microtubule-associated serine/threonine-protein kinase 3 isoform X2

Conserved Domains (3) summary

cd00992
Location:985 → 1062

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:402 → 681

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:87 → 367

DUF1908; Domain of unknown function (DUF1908)
XM_006509709.4 → XP_006509772.2 microtubule-associated serine/threonine-protein kinase 3 isoform X3

Conserved Domains (3) summary

cd00992
Location:979 → 1056

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:396 → 675

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:88 → 361

DUF1908; Domain of unknown function (DUF1908)
XM_017312909.2 → XP_017168398.1 microtubule-associated serine/threonine-protein kinase 3 isoform X4

Conserved Domains (3) summary

smart00228
Location:974 → 1055

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd05609
Location:395 → 674

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:80 → 360

DUF1908; Domain of unknown function (DUF1908)
XM_006509712.5 → XP_006509775.1 microtubule-associated serine/threonine-protein kinase 3 isoform X9

Conserved Domains (3) summary

cd00992
Location:961 → 1038

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:378 → 657

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:63 → 343

DUF1908; Domain of unknown function (DUF1908)