U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Tmem80 transmembrane protein 80 [ Mus musculus (house mouse) ]

    Gene ID: 71448, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tmem80provided by MGI
    Official Full Name
    transmembrane protein 80provided by MGI
    Primary source
    MGI:MGI:1918698
    See related
    Ensembl:ENSMUSG00000025505 AllianceGenome:MGI:1918698
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5530601I19Rik
    Summary
    Predicted to be involved in non-motile cilium assembly. Located in ciliary transition zone. Orthologous to human TMEM80 (transmembrane protein 80). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 8.6), thymus adult (RPKM 8.3) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tmem80 in Genome Data Viewer
    Location:
    7 F5; 7 86.65 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140908046..140917069)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141328130..141337156)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene dopamine receptor D4 Neighboring gene DEAF1, transcription factor Neighboring gene STARR-seq mESC enhancer starr_20486 Neighboring gene predicted gene, 53347 Neighboring gene STARR-positive B cell enhancer ABC_E4985 Neighboring gene EPS8-like 2 Neighboring gene RIKEN cDNA B230206H07 gene Neighboring gene STARR-seq mESC enhancer starr_20489 Neighboring gene predicted gene, 25725

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone. Li C, et al. PLoS Biol, 2016 Mar. PMID 26982032, Free PMC Article
    2. Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Horiuchi K, et al. Cell Rep, 2018 Apr 3. PMID 29617656
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in non-motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ciliary transition zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    transmembrane protein 80

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001141950.2 → NP_001135422.1  transmembrane protein 80 isoform 1

      See identical proteins and their annotated locations for NP_001135422.1

      Status: VALIDATED

      Source sequence(s)
      AC163434
      Consensus CDS
      CCDS22008.1
      UniProtKB/Swiss-Prot
      Q8BQL4, Q9D3H0
      Related
      ENSMUSP00000026578.8, ENSMUST00000026578.14
      Conserved Domains (1) summary
      pfam09799
      Location:4 → 107
      Transmemb_17; Predicted membrane protein

    2. NM_001374020.2 → NP_001360949.1  transmembrane protein 80 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163434
      Conserved Domains (1) summary
      pfam09799
      Location:24 → 127
      Transmemb_17; Predicted membrane protein

    3. NM_001374021.2 → NP_001360950.1  transmembrane protein 80 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163434
      Conserved Domains (1) summary
      pfam09799
      Location:24 → 96
      Transmemb_17; Predicted membrane protein

    4. NM_027797.4 → NP_082073.1  transmembrane protein 80 isoform 1

      See identical proteins and their annotated locations for NP_082073.1

      Status: VALIDATED

      Source sequence(s)
      AC163434
      Consensus CDS
      CCDS22008.1
      UniProtKB/Swiss-Prot
      Q8BQL4, Q9D3H0
      Related
      ENSMUSP00000116695.2, ENSMUST00000133012.8
      Conserved Domains (1) summary
      pfam09799
      Location:4 → 107
      Transmemb_17; Predicted membrane protein

    RNA

    1. NR_024509.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163434
      Related
      ENSMUST00000128649.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140908046..140917069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249858.2 → XP_011248160.1  transmembrane protein 80 isoform X1

      See identical proteins and their annotated locations for XP_011248160.1

      UniProtKB/Swiss-Prot
      Q8BQL4, Q9D3H0
      Conserved Domains (1) summary
      pfam09799
      Location:4 → 107
      Transmemb_17; Predicted membrane protein

    2. XM_036153437.1 → XP_036009330.1  transmembrane protein 80 isoform X1

      UniProtKB/Swiss-Prot
      Q8BQL4, Q9D3H0
      Related
      ENSMUSP00000123330.2, ENSMUST00000126510.8
      Conserved Domains (1) summary
      pfam09799
      Location:4 → 107
      Transmemb_17; Predicted membrane protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D3H0.1 GenPept UniProtKB/Swiss-Prot:Q9D3H0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools