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    GLIP1 GDSL lipase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834101, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLIP1
    Official Full Name
    GDSL lipase 1
    Primary source
    TAIR:AT5G40990
    Locus tag
    AT5G40990
    See related
    Araport:AT5G40990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    GDSL lipase 1; MEE6.6; MEE6_6
    Summary
    Component of plant resistance. Contains lipase signature motif and GDSL domain. Directly interferes with the fungal infection process by acting on fungal cell walls through its action as a antimicrobial compound. Critical component for both local and systemic resistance responses in the incompatible interaction with Alternaria brassicicola in the ethylene-dependent pathway.
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    Genomic context

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    See GLIP1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (16418842..16420616)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene hypothetical protein (DUF 3339) Neighboring gene AT.I.24-6 protein, putative (DUF 3339) Neighboring gene uncharacterized protein Neighboring gene YELLOW STRIPE like 4 Neighboring gene ncRNA Neighboring gene DNA directed RNA polymerase, 7 kDa subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GDSL lipase 1 regulates ethylene signaling and ethylene-associated systemic immunity in Arabidopsis. Kim HG, et al. FEBS Lett, 2014 May 2. PMID 24631536
    2. GDSL LIPASE1 modulates plant immunity through feedback regulation of ethylene signaling. Kim HG, et al. Plant Physiol, 2013 Dec. PMID 24170202, Free PMC Article
    3. GDSL lipase-like 1 regulates systemic resistance associated with ethylene signaling in Arabidopsis. Kwon SJ, et al. Plant J, 2009 Apr. PMID 19077166
    4. Secretome analysis reveals an Arabidopsis lipase involved in defense against Alternaria brassicicola. Oh IS, et al. Plant Cell, 2005 Oct. PMID 16126835, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GLIP1 regulates the fine-tuning of ethylene signaling and ethylene-salicylic acid cross talk.
      Title: GDSL LIPASE1 modulates plant immunity through feedback regulation of ethylene signaling.
    2. GLIP1 positively and negatively regulates ethylene signaling, resulting in an ethylene-associated, necrotroph-induced immune response.
      Title: GDSL lipase 1 regulates ethylene signaling and ethylene-associated systemic immunity in Arabidopsis.
    3. GLIP1-mediated pathogen resistance is dependent on ethylene signaling.
      Title: GDSL lipase-like 1 regulates systemic resistance associated with ethylene signaling in Arabidopsis.
    4. GDSL LIPASE1 (GLIP1), in association with ethylene signaling, may be a critical component in plant resistance to necrotrophic fungus Alternaria brassicicola.[GLIP1]
      Title: Secretome analysis reveals an Arabidopsis lipase involved in defense against Alternaria brassicicola.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within induced systemic resistance, ethylene mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salicylic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in systemic acquired resistance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GDSL lipase 1
    NP_198915.1
    • GDSL lipase 1 (GLIP1); CONTAINS InterPro DOMAIN/s: Lipase, GDSL, active site (InterPro:IPR008265), Lipase, GDSL (InterPro:IPR001087); BEST Arabidopsis thaliana protein match is: GDSL-motif lipase 2 (TAIR:AT1G53940.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16418842..16420616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123464.2 → NP_198915.1  GDSL lipase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198915.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FLN0
      UniProtKB/TrEMBL
      A0A654G700
      Conserved Domains (1) summary
      cd01837
      Location:37 → 358
      SGNH_plant_lipase_like; SGNH_plant_lipase_like, a plant specific subfamily of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FLN0.1

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