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    Cdh7 cadherin 7, type 2 [ Mus musculus (house mouse) ]

    Gene ID: 241201, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cdh7provided by MGI
    Official Full Name
    cadherin 7, type 2provided by MGI
    Primary source
    MGI:MGI:2442792
    See related
    Ensembl:ENSMUSG00000026312 AllianceGenome:MGI:2442792
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CDH7L1; 9330156F07Rik
    Summary
    This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related cadherin gene on chromosome 1. [provided by RefSeq, Oct 2015]
    Expression
    Biased expression in cerebellum adult (RPKM 1.6), CNS E18 (RPKM 1.0) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdh7 in Genome Data Viewer
    Location:
    1 E2.1; 1 50.73 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (109909967..110073002)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (109982237..110145272)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22159 Neighboring gene heat shock protein 8 pseudogene Neighboring gene predicted gene, 41930 Neighboring gene STARR-seq mESC enhancer starr_01887 Neighboring gene polo-like kinase 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Involvement of cadherins 7 and 20 in mouse embryogenesis and melanocyte transformation. Moore R, et al. Oncogene, 2004 Sep 2. PMID 15273735
    2. Study of smell and reproductive organs in a mouse model for CHARGE syndrome. Bergman JE, et al. Eur J Hum Genet, 2010 Feb. PMID 19809474, Free PMC Article
    3. Chromatin remodeler CHD7 is critical for cochlear morphogenesis and neurosensory patterning. Balendran V, et al. Dev Biol, 2021 Sep. PMID 34004180, Free PMC Article
    4. Comparative analysis of type II classic cadherin mRNA distribution patterns in the developing and adult mouse somatosensory cortex and hippocampus suggests significant functional redundancy. Lefkovics K, et al. J Comp Neurol, 2012 May 1. PMID 22102170
    5. Single-nucleus RNA sequencing of developing superior colliculus identifies neuronal diversity and candidate mediators of circuit assembly. Choi JS, et al. Cell Rep, 2023 Sep 26. PMID 37624694, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chromatin remodeler CHD7 is critical for cochlear morphogenesis and neurosensory patterning.
      Title: Chromatin remodeler CHD7 is critical for cochlear morphogenesis and neurosensory patterning.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118246

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cadherin-7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316743.1 → NP_001303672.1  cadherin-7 isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AC101794, AC166749, AK046426, BC083189, CJ130526
      Consensus CDS
      CCDS15221.1
      UniProtKB/Swiss-Prot
      Q3UVE2, Q67G09, Q8BM92
      UniProtKB/TrEMBL
      B2RUF4
      Related
      ENSMUSP00000027542.7, ENSMUST00000027542.13
      Conserved Domains (3) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats
      pfam01049
      Location:631 → 779
      Cadherin_C; Cadherin cytoplasmic region

    2. NM_001316744.1 → NP_001303673.1  cadherin-7 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC101794, AC166749, AK046426, BC083189
      UniProtKB/TrEMBL
      B2RUF4
      Conserved Domains (3) summary
      cd11304
      Location:99 → 200
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:15 → 93
      CA; Cadherin repeats
      pfam01049
      Location:581 → 719
      Cadherin_C; Cadherin cytoplasmic region

    3. NM_172853.3 → NP_766441.1  cadherin-7 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_766441.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AC101794, AK046426, BC083189
      Consensus CDS
      CCDS15221.1
      UniProtKB/Swiss-Prot
      Q3UVE2, Q67G09, Q8BM92
      UniProtKB/TrEMBL
      B2RUF4
      Related
      ENSMUSP00000129715.2, ENSMUST00000172005.8
      Conserved Domains (3) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats
      pfam01049
      Location:631 → 779
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      109909967..110073002
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320693.2 → XP_017176182.1  cadherin-7 isoform X1

      UniProtKB/Swiss-Prot
      Q3UVE2, Q67G09, Q8BM92
      UniProtKB/TrEMBL
      B2RUF4
      Conserved Domains (3) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats
      pfam01049
      Location:631 → 779
      Cadherin_C; Cadherin cytoplasmic region

    2. XM_006529608.3 → XP_006529671.1  cadherin-7 isoform X1

      See identical proteins and their annotated locations for XP_006529671.1

      UniProtKB/Swiss-Prot
      Q3UVE2, Q67G09, Q8BM92
      UniProtKB/TrEMBL
      B2RUF4
      Conserved Domains (3) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats
      pfam01049
      Location:631 → 779
      Cadherin_C; Cadherin cytoplasmic region

    3. XM_006529600.3 → XP_006529663.1  cadherin-7 isoform X1

      See identical proteins and their annotated locations for XP_006529663.1

      UniProtKB/Swiss-Prot
      Q3UVE2, Q67G09, Q8BM92
      UniProtKB/TrEMBL
      B2RUF4
      Conserved Domains (3) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats
      pfam01049
      Location:631 → 779
      Cadherin_C; Cadherin cytoplasmic region

    4. XM_036165096.1 → XP_036020989.1  cadherin-7 isoform X2

      UniProtKB/TrEMBL
      B2RUF4
      Conserved Domains (3) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats
      pfam01049
      Location:626 → 774
      Cadherin_C; Cadherin cytoplasmic region

    5. XM_017320698.1 → XP_017176187.1  cadherin-7 isoform X1

      UniProtKB/Swiss-Prot
      Q3UVE2, Q67G09, Q8BM92
      UniProtKB/TrEMBL
      B2RUF4
      Conserved Domains (3) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats
      pfam01049
      Location:631 → 779
      Cadherin_C; Cadherin cytoplasmic region

    6. XM_017320699.1 → XP_017176188.1  cadherin-7 isoform X1

      UniProtKB/Swiss-Prot
      Q3UVE2, Q67G09, Q8BM92
      UniProtKB/TrEMBL
      B2RUF4
      Conserved Domains (3) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats
      pfam01049
      Location:631 → 779
      Cadherin_C; Cadherin cytoplasmic region

    7. XM_036165091.1 → XP_036020984.1  cadherin-7 isoform X1

      UniProtKB/Swiss-Prot
      Q3UVE2, Q67G09, Q8BM92
      UniProtKB/TrEMBL
      B2RUF4
      Conserved Domains (3) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats
      pfam01049
      Location:631 → 779
      Cadherin_C; Cadherin cytoplasmic region

    8. XM_017320701.1 → XP_017176190.1  cadherin-7 isoform X1

      UniProtKB/Swiss-Prot
      Q3UVE2, Q67G09, Q8BM92
      UniProtKB/TrEMBL
      B2RUF4
      Conserved Domains (3) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats
      pfam01049
      Location:631 → 779
      Cadherin_C; Cadherin cytoplasmic region

    9. XM_006529601.3 → XP_006529664.1  cadherin-7 isoform X1

      See identical proteins and their annotated locations for XP_006529664.1

      UniProtKB/Swiss-Prot
      Q3UVE2, Q67G09, Q8BM92
      UniProtKB/TrEMBL
      B2RUF4
      Conserved Domains (3) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats
      pfam01049
      Location:631 → 779
      Cadherin_C; Cadherin cytoplasmic region

    10. XM_011248006.2 → XP_011246308.1  cadherin-7 isoform X1

      See identical proteins and their annotated locations for XP_011246308.1

      UniProtKB/Swiss-Prot
      Q3UVE2, Q67G09, Q8BM92
      UniProtKB/TrEMBL
      B2RUF4
      Conserved Domains (3) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats
      pfam01049
      Location:631 → 779
      Cadherin_C; Cadherin cytoplasmic region

    11. XM_006529609.3 → XP_006529672.1  cadherin-7 isoform X1

      See identical proteins and their annotated locations for XP_006529672.1

      UniProtKB/Swiss-Prot
      Q3UVE2, Q67G09, Q8BM92
      UniProtKB/TrEMBL
      B2RUF4
      Conserved Domains (3) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats
      pfam01049
      Location:631 → 779
      Cadherin_C; Cadherin cytoplasmic region

    12. XM_017320706.2 → XP_017176195.1  cadherin-7 isoform X3

      Conserved Domains (2) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats

    13. XM_017320703.2 → XP_017176192.1  cadherin-7 isoform X1

      UniProtKB/Swiss-Prot
      Q3UVE2, Q67G09, Q8BM92
      UniProtKB/TrEMBL
      B2RUF4
      Conserved Domains (3) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats
      pfam01049
      Location:631 → 779
      Cadherin_C; Cadherin cytoplasmic region

    14. XM_006529610.4 → XP_006529673.1  cadherin-7 isoform X1

      See identical proteins and their annotated locations for XP_006529673.1

      UniProtKB/Swiss-Prot
      Q3UVE2, Q67G09, Q8BM92
      UniProtKB/TrEMBL
      B2RUF4
      Conserved Domains (3) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats
      pfam01049
      Location:631 → 779
      Cadherin_C; Cadherin cytoplasmic region

    15. XM_006529611.4 → XP_006529674.1  cadherin-7 isoform X1

      See identical proteins and their annotated locations for XP_006529674.1

      UniProtKB/Swiss-Prot
      Q3UVE2, Q67G09, Q8BM92
      UniProtKB/TrEMBL
      B2RUF4
      Related
      ENSMUSP00000108321.2, ENSMUST00000112701.8
      Conserved Domains (3) summary
      cd11304
      Location:157 → 258
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 151
      CA; Cadherin repeats
      pfam01049
      Location:631 → 779
      Cadherin_C; Cadherin cytoplasmic region

    16. XM_011248008.4 → XP_011246310.1  cadherin-7 isoform X4

      Conserved Domains (2) summary
      cd11304
      Location:2 → 95
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:248 → 396
      Cadherin_C; Cadherin cytoplasmic region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BM92.1 GenPept UniProtKB/Swiss-Prot:Q8BM92

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