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    ARL9 ARF like GTPase 9 [ Homo sapiens (human) ]

    Gene ID: 132946, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ARL9provided by HGNC
    Official Full Name
    ARF like GTPase 9provided by HGNC
    Primary source
    HGNC:HGNC:23592
    See related
    Ensembl:ENSG00000196503 MIM:612405; AllianceGenome:HGNC:23592
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    ARL9 is a member of the small GTPase protein family with a high degree of similarity to ARF (MIM 103180) proteins of the RAS superfamily.[supplied by OMIM, Nov 2008]
    Expression
    Biased expression in testis (RPKM 1.5), skin (RPKM 0.3) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ARL9 in Genome Data Viewer
    Location:
    4q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (56505209..56524453)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (59993215..60012461)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (57371375..57390619)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase Neighboring gene uncharacterized LOC124900706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21580 Neighboring gene signal recognition particle 72 Neighboring gene uncharacterized LOC105377665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:57397246-57397779 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15451 Neighboring gene sperm microtubule associated protein 2 like Neighboring gene ReSE screen-validated silencer GRCh37_chr4:57424181-57424393 Neighboring gene NANOG hESC enhancer GRCh37_chr4:57472386-57472887 Neighboring gene glycine decarboxylase pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15452 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:57501823-57502323 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:57506917-57508116 Neighboring gene uncharacterized LOC124900708 Neighboring gene hESC enhancers GRCh37_chr4:57528805-57529620 and GRCh37_chr4:57529621-57530435 Neighboring gene HOP homeobox

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ARL9 is upregulated and serves as a biomarker for a poor prognosis in colon adenocarcinoma. Yang HD, et al. BMC Gastroenterol, 2023 Feb 23. PMID 36823542, Free PMC Article
    2. Prognostic significance of ARL9 and its methylation in low-grade glioma. Tan Y, et al. Genomics, 2020 Nov. PMID 32882327, Free PMC Article
    3. RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors. Louro R, et al. Biochem Biophys Res Commun, 2004 Apr 9. PMID 15033445
    4. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975
    5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARL9 is upregulated and serves as a biomarker for a poor prognosis in colon adenocarcinoma.
      Title: ARL9 is upregulated and serves as a biomarker for a poor prognosis in colon adenocarcinoma.
    2. Prognostic significance of ARL9 and its methylation in low-grade glioma.
      Title: Prognostic significance of ARL9 and its methylation in low-grade glioma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of ADP-ribosylation factor-like 9 (ARL9) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 9
    Names
    ADP ribosylation factor like GTPase 9
    ADP-ribosylation factor-like 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363794.2 → NP_001350723.1  ADP-ribosylation factor-like protein 9 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC108215, AC114766
      Consensus CDS
      CCDS87224.1
      UniProtKB/TrEMBL
      A0A1W2PS79
      Related
      ENSP00000492671.3, ENST00000640821.3
      Conserved Domains (1) summary
      cd04162
      Location:98 → 263
      Arl9_Arfrp2_like; Arf-like 9 (Arl9)/Arfrp2-like GTPase

    2. NM_001401357.1 → NP_001388286.1  ADP-ribosylation factor-like protein 9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC108215, AC114766
      Consensus CDS
      CCDS59474.1

    3. NM_001401358.1 → NP_001388287.1  ADP-ribosylation factor-like protein 9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC108215, AC114766

    4. NM_001401359.1 → NP_001388288.1  ADP-ribosylation factor-like protein 9 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC108215, AC114766

    5. NM_001401360.1 → NP_001388289.1  ADP-ribosylation factor-like protein 9 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC108215, AC114766

    6. NM_001401361.1 → NP_001388290.1  ADP-ribosylation factor-like protein 9 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC108215, AC114766

    7. NM_206919.3 → NP_996802.1  ADP-ribosylation factor-like protein 9 isoform 2

      See identical proteins and their annotated locations for NP_996802.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC108215, AC114766
      Consensus CDS
      CCDS59474.1
      UniProtKB/Swiss-Prot
      Q6T311
      Related
      ENSP00000353210.2, ENST00000360096.3
      Conserved Domains (1) summary
      cl21455
      Location:1 → 121
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      56505209..56524453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449613.1 → XP_047305569.1  ADP-ribosylation factor-like protein 9 isoform X2

    2. XM_005265720.5 → XP_005265777.1  ADP-ribosylation factor-like protein 9 isoform X1

      See identical proteins and their annotated locations for XP_005265777.1

      UniProtKB/Swiss-Prot
      Q6T311
      Conserved Domains (1) summary
      cl21455
      Location:1 → 121
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      59993215..60012461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348938.1 → XP_054204913.1  ADP-ribosylation factor-like protein 9 isoform X2

    2. XM_054348937.1 → XP_054204912.1  ADP-ribosylation factor-like protein 9 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6T311.1 GenPept UniProtKB/Swiss-Prot:Q6T311

    Gene LinkOut

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