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    Mtmr6 myotubularin related protein 6 [ Mus musculus (house mouse) ]

    Gene ID: 219135, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtmr6provided by MGI
    Official Full Name
    myotubularin related protein 6provided by MGI
    Primary source
    MGI:MGI:2145637
    See related
    Ensembl:ENSMUSG00000021987 AllianceGenome:MGI:2145637
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm38641; 4022440C11Rik
    Summary
    Predicted to enable phosphatidylinositol-3,5-bisphosphate phosphatase activity and phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be located in endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; and ruffle membrane. Predicted to be active in cytoplasm and nuclear envelope. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MTMR6 (myotubularin related protein 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 32.5), cerebellum adult (RPKM 18.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mtmr6 in Genome Data Viewer
    Location:
    14; 14 D1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (60488941..60539820)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (60265180..60302371)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57492 Neighboring gene nucleoporin 58 Neighboring gene STARR-seq mESC enhancer starr_36855 Neighboring gene microRNA 719 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:60870359-60870542 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:60883833-60884016 Neighboring gene predicted gene, 34874 Neighboring gene STARR-seq mESC enhancer starr_36856 Neighboring gene STARR-seq mESC enhancer starr_36857 Neighboring gene APC membrane recruitment 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways. Mochizuki Y, et al. J Biol Chem, 2013 Jan 11. PMID 23188820, Free PMC Article
    2. Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. Mochizuki Y, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12890864, Free PMC Article
    3. Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis. Maekawa M, et al. Proc Natl Acad Sci U S A, 2014 Mar 18. PMID 24591580, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC27983

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6; myotubularin-related protein 6
    Names
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase
    phosphatidylinositol-3-phosphate phosphatase
    NP_001388127.1
    NP_001388128.1
    NP_001388129.1
    NP_659092.1
    XP_017171461.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401198.1 → NP_001388127.1  phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166113

    2. NM_001401199.1 → NP_001388128.1  phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166113

    3. NM_001401200.1 → NP_001388129.1  phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166113
      Related
      ENSMUSP00000153403.2, ENSMUST00000224366.2

    4. NM_144843.5 → NP_659092.1  phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 isoform 1

      See identical proteins and their annotated locations for NP_659092.1

      Status: VALIDATED

      Source sequence(s)
      AC166113
      Consensus CDS
      CCDS27176.1
      UniProtKB/Swiss-Prot
      L8AZD2, Q8VE11
      Related
      ENSMUSP00000022563.8, ENSMUST00000022563.9
      Conserved Domains (2) summary
      cd13343
      Location:1 → 101
      PH-GRAM_MTMR6; Myotubularian (MTM) related (MTMR) 6 protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam06602
      Location:107 → 444
      Myotub-related; Myotubularin-like phosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      60488941..60539820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315972.3 → XP_017171461.1  myotubularin-related protein 6 isoform X2

      Conserved Domains (2) summary
      cl17171
      Location:2 → 95
      PH-like; Pleckstrin homology-like domain
      cl28904
      Location:124 → 463
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VE11.1 GenPept UniProtKB/Swiss-Prot:Q8VE11

    Gene LinkOut

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