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    Pin4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684441, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pin4provided by RGD
    Official Full Name
    peptidylprolyl cis/trans isomerase, NIMA-interacting 4provided by RGD
    Primary source
    RGD:1590326
    See related
    EnsemblRapid:ENSRNOG00000050051 AllianceGenome:RGD:1590326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable bent DNA binding activity and double-stranded DNA binding activity. Predicted to be involved in rRNA processing. Predicted to be located in several cellular components, including mitochondrial matrix; nuclear lumen; and spindle. Predicted to be part of preribosome. Predicted to be active in nucleus. Orthologous to human PIN4 (peptidylprolyl cis/trans isomerase, NIMA-interacting 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 91.9), Heart (RPKM 84.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pin4 in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (71272034..71278676)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (67232066..67238709)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (72004413..72011667)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome X open reading frame 49 like 1 Neighboring gene NHS-like 2 Neighboring gene retrotransposon Gag like 5 Neighboring gene uncharacterized LOC134484080 Neighboring gene small nuclear ribonucleoprotein D2 polypeptide, pseudogene 2 Neighboring gene ERCC excision repair 6 like, spindle assembly checkpoint helicase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Parvulin (Par14), a peptidyl-prolyl cis-trans isomerase, is a novel rRNA processing factor that evolved in the metazoan lineage. Fujiyama-Nakamura S, et al. Mol Cell Proteomics, 2009 Jul. PMID 19369196, Free PMC Article
    2. The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae. Kessler D, et al. BMC Biol, 2007 Sep 17. PMID 17875217, Free PMC Article
    3. The N-terminal basic domain of human parvulin hPar14 is responsible for the entry to the nucleus and high-affinity DNA-binding. Surmacz TA, et al. J Mol Biol, 2002 Aug 9. PMID 12144781
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bent DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of preribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
    Names
    protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
    NP_001388140.1
    NP_001388141.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401211.1 → NP_001388140.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6IQE1
      Related
      ENSRNOP00000067375.3, ENSRNOT00000073157.3

    2. NM_001401212.1 → NP_001388141.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      M0RCP9
      Conserved Domains (1) summary
      cl29122
      Location:41 → 142
      Rotamase_2; PPIC-type PPIASE domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      71272034..71278676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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