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    Ppm1m protein phosphatase 1M [ Mus musculus (house mouse) ]

    Gene ID: 67905, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ppm1mprovided by MGI
    Official Full Name
    protein phosphatase 1Mprovided by MGI
    Primary source
    MGI:MGI:1915155
    See related
    Ensembl:ENSMUSG00000020253 AllianceGenome:MGI:1915155
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PP2Ceta; 2810423O19Rik
    Summary
    Enables manganese ion binding activity and phosphoprotein phosphatase activity. Involved in protein dephosphorylation. Located in nucleus. Is expressed in brain; genitourinary system; heart; liver; and respiratory system. Orthologous to human PPM1M (protein phosphatase, Mg2+/Mn2+ dependent 1M). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 103.2), mammary gland adult (RPKM 42.3) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppm1m in Genome Data Viewer
    Location:
    9 F1; 9 57.46 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106072152..106076432, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106194953..106199233, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D030055H07 gene Neighboring gene STARR-positive B cell enhancer ABC_E8311 Neighboring gene microRNA 135a-1 Neighboring gene glycerate kinase Neighboring gene STARR-seq mESC enhancer starr_25138 Neighboring gene STARR-seq mESC enhancer starr_25140 Neighboring gene WD repeat domain containing 82 Neighboring gene microRNA let7g Neighboring gene STARR-positive B cell enhancer ABC_E8312 Neighboring gene twinfilin actin binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E5101 Neighboring gene toll-like receptor 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mechanism for the suppression of interleukin-1-induced nuclear factor kappaB activation by protein phosphatase 2Ceta-2. Henmi T, et al. Biochem J, 2009 Sep 14. PMID 19594441
    2. Molecular cloning of PP2Ceta, a novel member of the protein phosphatase 2C family. Komaki K, et al. Biochim Biophys Acta, 2003 Nov 30. PMID 14654243
    3. N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells. Chida T, et al. Biochem J, 2013 Feb 1. PMID 23088624
    4. Global gene expression analysis of murine limb development. Taher L, et al. PLoS One, 2011. PMID 22174793, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein phosphatase 1M
    Names
    PP2C-eta
    PP2CE
    protein phosphatase 2C eta
    protein phosphatase 2C eta-2
    NP_080723.3
    NP_945149.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026447.4 → NP_080723.3  protein phosphatase 1M isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC058248, BY202563
      Consensus CDS
      CCDS23472.2
      UniProtKB/Swiss-Prot
      E9Q2I3, Q8BU27, Q9CSD6, Q9CU88
      UniProtKB/TrEMBL
      A0A8I4Q8Y8
      Related
      ENSMUSP00000117908.2, ENSMUST00000140761.9
      Conserved Domains (1) summary
      cd00143
      Location:109 → 452
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    2. NM_198931.3 → NP_945149.2  protein phosphatase 1M isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate first exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC164430, AY332616, BC058248
      Consensus CDS
      CCDS23471.1
      UniProtKB/Swiss-Prot
      E9Q2I3, Q8BU27, Q9CSD6, Q9CU88
      UniProtKB/TrEMBL
      F8WGF9
      Related
      ENSMUSP00000075607.6, ENSMUST00000076258.13
      Conserved Domains (1) summary
      cd00143
      Location:53 → 396
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      106072152..106076432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BU27.3 GenPept UniProtKB/Swiss-Prot:Q8BU27

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