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    MGA MAX dimerization protein MGA [ Homo sapiens (human) ]

    Gene ID: 23269, updated on 27-Nov-2024

    Summary

    Official Symbol
    MGAprovided by HGNC
    Official Full Name
    MAX dimerization protein MGAprovided by HGNC
    Primary source
    HGNC:HGNC:14010
    See related
    Ensembl:ENSG00000174197 MIM:616061; AllianceGenome:HGNC:14010
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAD5; MXD5
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Part of MLL1 complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 5.9), testis (RPKM 5.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MGA in Genome Data Viewer
    Location:
    15q15.1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (41621224..41769940)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (39427379..39575822)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41913422..42062138)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41851897-41852538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41854571-41855258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41856635-41857321 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41860135-41860642 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41860643-41861148 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41861657-41862163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6366 Neighboring gene TYRO3 protein tyrosine kinase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41888161-41888662 Neighboring gene uncharacterized LOC105370791 Neighboring gene uncharacterized LOC124903614 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6367 Neighboring gene microRNA 626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9285 Neighboring gene mitogen-activated protein kinase binding protein 1 Neighboring gene JMJD7-PLA2G4B readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:42117960-42118842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9286 Neighboring gene Sharpr-MPRA regulatory region 5929 Neighboring gene jumonji domain containing 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12634, KIAA0518

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of MLL1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of MLL1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    MAX gene-associated protein
    Names
    MAX dimerization protein 5
    MGA, MAX dimerization protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080541.3NP_001074010.2  MAX gene-associated protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA188751, AB011090, AC016134, AC073657, BC136659, BQ937819, BX643019, DC391039, DR001080
      Consensus CDS
      CCDS55960.1
      UniProtKB/TrEMBL
      A0A8C8P5L8
      Related
      ENSP00000456141.1, ENST00000566586.6
      Conserved Domains (3) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:22162266
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10411087
      DUF4801; Domain of unknown function (DUF4801)
    2. NM_001164273.2NP_001157745.1  MAX gene-associated protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC016134, AC073657
      Consensus CDS
      CCDS55959.1
      UniProtKB/Swiss-Prot
      B9EGR5, E7ENI0, F5H7K2, Q8IWI9, Q9H8R3, Q9H9N7, Q9UG69, Q9Y4E9
      UniProtKB/TrEMBL
      A0A8C8P5L8
      Related
      ENSP00000219905.7, ENST00000219905.13
      Conserved Domains (5) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam03154
      Location:16891983
      Atrophin-1; Atrophin-1 family
      pfam16059
      Location:10411083
      DUF4801; Domain of unknown function (DUF4801)
      pfam17823
      Location:14691771
      DUF5585; Family of unknown function (DUF5585)
      cd18911
      Location:24252489
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins
    3. NM_001400225.1NP_001387154.1  MAX gene-associated protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC016134, AC073657
      Consensus CDS
      CCDS91982.1
      UniProtKB/TrEMBL
      A0A994J6L2
      Related
      ENSP00000515495.1, ENST00000703841.1
    4. NM_001400242.1NP_001387171.1  MAX gene-associated protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC016134, AC073657
    5. NM_001400243.1NP_001387172.1  MAX gene-associated protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC016134, AC073657
      Related
      ENST00000682463.1
    6. NM_001400244.1NP_001387173.1  MAX gene-associated protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC016134, AC073657
    7. NM_001400245.1NP_001387174.1  MAX gene-associated protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC016134, AC073657
    8. NM_001400246.1NP_001387175.1  MAX gene-associated protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC016134, AC073657
    9. NM_001400247.1NP_001387176.1  MAX gene-associated protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC016134, AC073657

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      41621224..41769940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022029.3XP_016877518.1  MAX gene-associated protein isoform X16

      Conserved Domains (2) summary
      pfam00010
      Location:20182068
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:584630
      DUF4801; Domain of unknown function (DUF4801)
    2. XM_047432300.1XP_047288256.1  MAX gene-associated protein isoform X18

    3. XM_047432302.1XP_047288258.1  MAX gene-associated protein isoform X19

    4. XM_005254246.4XP_005254303.1  MAX gene-associated protein isoform X1

      See identical proteins and their annotated locations for XP_005254303.1

      UniProtKB/TrEMBL
      A0A8C8P5L8
      Conserved Domains (3) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:24752525
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10411087
      DUF4801; Domain of unknown function (DUF4801)
    5. XM_047432276.1XP_047288232.1  MAX gene-associated protein isoform X2

      UniProtKB/TrEMBL
      A0A994J6L2
      Related
      ENSP00000457035.2, ENST00000570161.6
    6. XM_047432286.1XP_047288242.1  MAX gene-associated protein isoform X9

    7. XM_047432288.1XP_047288244.1  MAX gene-associated protein isoform X10

    8. XM_047432279.1XP_047288235.1  MAX gene-associated protein isoform X3

    9. XM_047432280.1XP_047288236.1  MAX gene-associated protein isoform X4

      UniProtKB/Swiss-Prot
      B9EGR5, E7ENI0, F5H7K2, Q8IWI9, Q9H8R3, Q9H9N7, Q9UG69, Q9Y4E9
    10. XM_047432291.1XP_047288247.1  MAX gene-associated protein isoform X12

    11. XM_047432281.1XP_047288237.1  MAX gene-associated protein isoform X6

    12. XM_047432295.1XP_047288251.1  MAX gene-associated protein isoform X14

    13. XM_047432298.1XP_047288254.1  MAX gene-associated protein isoform X15

    14. XM_006720445.5XP_006720508.1  MAX gene-associated protein isoform X16

      Conserved Domains (2) summary
      pfam00010
      Location:20182068
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:584630
      DUF4801; Domain of unknown function (DUF4801)
    15. XM_047432299.1XP_047288255.1  MAX gene-associated protein isoform X17

    16. XM_047432305.1XP_047288261.1  MAX gene-associated protein isoform X22

    17. XM_047432306.1XP_047288262.1  MAX gene-associated protein isoform X23

    18. XM_047432301.1XP_047288257.1  MAX gene-associated protein isoform X19

    19. XM_047432307.1XP_047288263.1  MAX gene-associated protein isoform X24

    20. XM_047432303.1XP_047288259.1  MAX gene-associated protein isoform X20

    21. XM_047432308.1XP_047288264.1  MAX gene-associated protein isoform X25

    22. XM_047432304.1XP_047288260.1  MAX gene-associated protein isoform X21

    23. XM_005254243.4XP_005254300.1  MAX gene-associated protein isoform X1

      See identical proteins and their annotated locations for XP_005254300.1

      UniProtKB/TrEMBL
      A0A8C8P5L8
      Conserved Domains (3) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:24752525
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10411087
      DUF4801; Domain of unknown function (DUF4801)
    24. XM_005254253.4XP_005254310.1  MAX gene-associated protein isoform X9

      UniProtKB/TrEMBL
      A0A8C8P5L8
      Conserved Domains (3) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:22662316
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10411087
      DUF4801; Domain of unknown function (DUF4801)
    25. XM_047432287.1XP_047288243.1  MAX gene-associated protein isoform X10

    26. XM_005254249.4XP_005254306.1  MAX gene-associated protein isoform X3

      UniProtKB/TrEMBL
      A0A8C8P5L8
      Conserved Domains (3) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:24262476
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10411087
      DUF4801; Domain of unknown function (DUF4801)
    27. XM_047432290.1XP_047288246.1  MAX gene-associated protein isoform X11

    28. XM_011521397.4XP_011519699.1  MAX gene-associated protein isoform X5

      UniProtKB/TrEMBL
      A0A8C8P5L8
      Conserved Domains (3) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:23652415
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10411087
      DUF4801; Domain of unknown function (DUF4801)
    29. XM_011521398.4XP_011519700.1  MAX gene-associated protein isoform X6

      UniProtKB/TrEMBL
      A0A8C8P5L8
      Conserved Domains (3) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:23642414
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10411087
      DUF4801; Domain of unknown function (DUF4801)
    30. XM_047432292.1XP_047288248.1  MAX gene-associated protein isoform X13

    31. XM_047432293.1XP_047288249.1  MAX gene-associated protein isoform X14

    32. XM_005254252.4XP_005254309.1  MAX gene-associated protein isoform X7

      UniProtKB/TrEMBL
      A0A8C8P5L8
      Conserved Domains (3) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:23162366
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10411087
      DUF4801; Domain of unknown function (DUF4801)
    33. XM_047432283.1XP_047288239.1  MAX gene-associated protein isoform X8

    34. XM_047432297.1XP_047288253.1  MAX gene-associated protein isoform X15

    35. XM_006720443.5XP_006720506.1  MAX gene-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006720506.1

      UniProtKB/TrEMBL
      A0A8C8P5L8
      Conserved Domains (3) summary
      cd00182
      Location:74264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:24752525
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:10411087
      DUF4801; Domain of unknown function (DUF4801)
    36. XM_047432278.1XP_047288234.1  MAX gene-associated protein isoform X2

      UniProtKB/TrEMBL
      A0A994J6L2
    37. XM_047432289.1XP_047288245.1  MAX gene-associated protein isoform X10

    38. XM_047432282.1XP_047288238.1  MAX gene-associated protein isoform X6

    39. XM_047432296.1XP_047288252.1  MAX gene-associated protein isoform X14

    40. XM_047432285.1XP_047288241.1  MAX gene-associated protein isoform X8

    41. XM_047432310.1XP_047288266.1  MAX gene-associated protein isoform X29

    42. XM_047432312.1XP_047288268.1  MAX gene-associated protein isoform X30

    43. XM_047432309.1XP_047288265.1  MAX gene-associated protein isoform X28

    44. XM_047432311.1XP_047288267.1  MAX gene-associated protein isoform X30

    45. XM_047432313.1XP_047288269.1  MAX gene-associated protein isoform X31

    46. XM_005254254.5XP_005254311.1  MAX gene-associated protein isoform X26

      Conserved Domains (1) summary
      pfam00010
      Location:9871037
      HLH; Helix-loop-helix DNA-binding domain
    47. XM_011521399.4XP_011519701.1  MAX gene-associated protein isoform X27

      See identical proteins and their annotated locations for XP_011519701.1

      Conserved Domains (1) summary
      pfam00010
      Location:924974
      HLH; Helix-loop-helix DNA-binding domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      39427379..39575822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377597.1XP_054233572.1  MAX gene-associated protein isoform X16

    2. XM_054377600.1XP_054233575.1  MAX gene-associated protein isoform X18

    3. XM_054377602.1XP_054233577.1  MAX gene-associated protein isoform X19

    4. XM_054377570.1XP_054233545.1  MAX gene-associated protein isoform X1

    5. XM_054377572.1XP_054233547.1  MAX gene-associated protein isoform X2

    6. XM_054377585.1XP_054233560.1  MAX gene-associated protein isoform X9

    7. XM_054377587.1XP_054233562.1  MAX gene-associated protein isoform X10

    8. XM_054377575.1XP_054233550.1  MAX gene-associated protein isoform X3

    9. XM_054377576.1XP_054233551.1  MAX gene-associated protein isoform X4

    10. XM_054377590.1XP_054233565.1  MAX gene-associated protein isoform X12

    11. XM_054377579.1XP_054233554.1  MAX gene-associated protein isoform X6

    12. XM_054377593.1XP_054233568.1  MAX gene-associated protein isoform X14

    13. XM_054377596.1XP_054233571.1  MAX gene-associated protein isoform X15

    14. XM_054377598.1XP_054233573.1  MAX gene-associated protein isoform X16

    15. XM_054377599.1XP_054233574.1  MAX gene-associated protein isoform X17

    16. XM_054377605.1XP_054233580.1  MAX gene-associated protein isoform X22

    17. XM_054377606.1XP_054233581.1  MAX gene-associated protein isoform X23

    18. XM_054377601.1XP_054233576.1  MAX gene-associated protein isoform X19

    19. XM_054377607.1XP_054233582.1  MAX gene-associated protein isoform X24

    20. XM_054377603.1XP_054233578.1  MAX gene-associated protein isoform X20

    21. XM_054377608.1XP_054233583.1  MAX gene-associated protein isoform X25

    22. XM_054377604.1XP_054233579.1  MAX gene-associated protein isoform X21

    23. XM_054377569.1XP_054233544.1  MAX gene-associated protein isoform X1

    24. XM_054377584.1XP_054233559.1  MAX gene-associated protein isoform X9

    25. XM_054377586.1XP_054233561.1  MAX gene-associated protein isoform X10

    26. XM_054377574.1XP_054233549.1  MAX gene-associated protein isoform X3

    27. XM_054377589.1XP_054233564.1  MAX gene-associated protein isoform X11

    28. XM_054377577.1XP_054233552.1  MAX gene-associated protein isoform X5

    29. XM_054377578.1XP_054233553.1  MAX gene-associated protein isoform X6

    30. XM_054377591.1XP_054233566.1  MAX gene-associated protein isoform X13

    31. XM_054377592.1XP_054233567.1  MAX gene-associated protein isoform X14

    32. XM_054377581.1XP_054233556.1  MAX gene-associated protein isoform X7

    33. XM_054377582.1XP_054233557.1  MAX gene-associated protein isoform X8

    34. XM_054377595.1XP_054233570.1  MAX gene-associated protein isoform X15

    35. XM_054377571.1XP_054233546.1  MAX gene-associated protein isoform X1

    36. XM_054377573.1XP_054233548.1  MAX gene-associated protein isoform X2

    37. XM_054377588.1XP_054233563.1  MAX gene-associated protein isoform X10

    38. XM_054377580.1XP_054233555.1  MAX gene-associated protein isoform X6

    39. XM_054377594.1XP_054233569.1  MAX gene-associated protein isoform X14

    40. XM_054377583.1XP_054233558.1  MAX gene-associated protein isoform X8

    41. XM_054377612.1XP_054233587.1  MAX gene-associated protein isoform X29

    42. XM_054377614.1XP_054233589.1  MAX gene-associated protein isoform X30

    43. XM_054377611.1XP_054233586.1  MAX gene-associated protein isoform X28

    44. XM_054377613.1XP_054233588.1  MAX gene-associated protein isoform X30

    45. XM_054377615.1XP_054233590.1  MAX gene-associated protein isoform X31

    46. XM_054377609.1XP_054233584.1  MAX gene-associated protein isoform X26

    47. XM_054377610.1XP_054233585.1  MAX gene-associated protein isoform X27