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    NR2C2 nuclear receptor subfamily 2 group C member 2 [ Homo sapiens (human) ]

    Gene ID: 7182, updated on 10-Dec-2024

    Summary

    Official Symbol
    NR2C2provided by HGNC
    Official Full Name
    nuclear receptor subfamily 2 group C member 2provided by HGNC
    Primary source
    HGNC:HGNC:7972
    See related
    Ensembl:ENSG00000177463 MIM:601426; AllianceGenome:HGNC:7972
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TR4; TAK1
    Summary
    This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
    Expression
    Ubiquitous expression in brain (RPKM 10.5), thyroid (RPKM 9.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NR2C2 in Genome Data Viewer
    Location:
    3p25.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (14947583..15049273)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (14950033..15051696)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (14989090..15090780)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14845672-14846414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14852491-14852991 Neighboring gene long intergenic non-protein coding RNA 2011 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:14855464-14855666 Neighboring gene FYVE, RhoGEF and PH domain containing 5 Neighboring gene Sharpr-MPRA regulatory region 8692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14905091-14905672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14920327-14920828 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14941355-14942238 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14942239-14943121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14955453-14956275 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14956276-14957097 Neighboring gene uncharacterized LOC105376963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14962633-14963132 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:14963648-14964847 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:14965692-14965871 Neighboring gene Sharpr-MPRA regulatory region 15385 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14988241-14988930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14097 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14989619-14990306 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14990307-14990994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19523 Neighboring gene FGD5 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:15066535-15067034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19525 Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14100 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:15139860-15140724 Neighboring gene rabenosyn, RAB effector Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:15149813-15150312 Neighboring gene ribosomal protein S24 pseudogene 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    nuclear receptor subfamily 2 group C member 2
    Names
    Nuclear hormone receptor TR4
    orphan nuclear receptor TAK1
    orphan nuclear receptor TR4
    orphan receptor TR4
    testicular nuclear receptor 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291694.2NP_001278623.1  nuclear receptor subfamily 2 group C member 2 isoform 2

      See identical proteins and their annotated locations for NP_001278623.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC090937, AC090954, AI986459, AK290590
      Consensus CDS
      CCDS74905.1
      UniProtKB/Swiss-Prot
      A8K3H5, B6ZGT8, P49116, P55092
      UniProtKB/TrEMBL
      Q6PHZ7
      Related
      ENSP00000388387.1, ENST00000425241.6
      Conserved Domains (2) summary
      cd06952
      Location:361582
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:112198
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    2. NM_003298.5NP_003289.2  nuclear receptor subfamily 2 group C member 2 isoform 1

      See identical proteins and their annotated locations for NP_003289.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC090937, AC090954, AI986459, AK290590, L27586
      Consensus CDS
      CCDS2621.1
      UniProtKB/TrEMBL
      A0A024R2N9, F2YGU2, Q6PHZ7
      Related
      ENSP00000320447.6, ENST00000323373.10
      Conserved Domains (2) summary
      cd06952
      Location:380601
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:131217
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      14947583..15049273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448826.1XP_047304782.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:413634
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:164250
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    2. XM_047448825.1XP_047304781.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:413634
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:164250
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    3. XM_047448830.1XP_047304786.1  nuclear receptor subfamily 2 group C member 2 isoform X3

    4. XM_047448829.1XP_047304785.1  nuclear receptor subfamily 2 group C member 2 isoform X2

      UniProtKB/TrEMBL
      Q6PHZ7
    5. XM_011534058.4XP_011532360.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      See identical proteins and their annotated locations for XP_011532360.1

      UniProtKB/TrEMBL
      Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:413634
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:164250
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    6. XM_047448836.1XP_047304792.1  nuclear receptor subfamily 2 group C member 2 isoform X7

      UniProtKB/TrEMBL
      Q6PHZ7
    7. XM_011534063.4XP_011532365.1  nuclear receptor subfamily 2 group C member 2 isoform X3

      See identical proteins and their annotated locations for XP_011532365.1

      Conserved Domains (2) summary
      cd06952
      Location:394615
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:145231
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    8. XM_011534064.4XP_011532366.1  nuclear receptor subfamily 2 group C member 2 isoform X5

      See identical proteins and their annotated locations for XP_011532366.1

      UniProtKB/TrEMBL
      A0A024R2N9, F2YGU2, Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:380601
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:131217
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    9. XM_047448827.1XP_047304783.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:413634
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:164250
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    10. XM_011534065.4XP_011532367.1  nuclear receptor subfamily 2 group C member 2 isoform X5

      See identical proteins and their annotated locations for XP_011532367.1

      UniProtKB/TrEMBL
      A0A024R2N9, F2YGU2, Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:380601
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:131217
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    11. XM_011534061.4XP_011532363.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      See identical proteins and their annotated locations for XP_011532363.1

      UniProtKB/TrEMBL
      Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:413634
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:164250
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    12. XM_047448837.1XP_047304793.1  nuclear receptor subfamily 2 group C member 2 isoform X7

      UniProtKB/TrEMBL
      Q6PHZ7
    13. XM_047448832.1XP_047304788.1  nuclear receptor subfamily 2 group C member 2 isoform X3

    14. XM_047448838.1XP_047304794.1  nuclear receptor subfamily 2 group C member 2 isoform X8

      UniProtKB/TrEMBL
      Q6PHZ7
    15. XM_047448835.1XP_047304791.1  nuclear receptor subfamily 2 group C member 2 isoform X6

      UniProtKB/TrEMBL
      Q6PHZ7
    16. XM_011534059.3XP_011532361.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      See identical proteins and their annotated locations for XP_011532361.1

      UniProtKB/TrEMBL
      Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:413634
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:164250
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    17. XM_047448831.1XP_047304787.1  nuclear receptor subfamily 2 group C member 2 isoform X3

    18. XM_047448828.1XP_047304784.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:413634
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:164250
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    19. XM_047448824.1XP_047304780.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:413634
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:164250
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    20. XM_047448834.1XP_047304790.1  nuclear receptor subfamily 2 group C member 2 isoform X5

      UniProtKB/TrEMBL
      A0A024R2N9, F2YGU2, Q6PHZ7
      Related
      ENSP00000483059.1, ENST00000617312.4
    21. XM_011534066.4XP_011532368.1  nuclear receptor subfamily 2 group C member 2 isoform X5

      See identical proteins and their annotated locations for XP_011532368.1

      UniProtKB/TrEMBL
      A0A024R2N9, F2YGU2, Q6PHZ7
      Conserved Domains (2) summary
      cd06952
      Location:380601
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:131217
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    22. XM_047448833.1XP_047304789.1  nuclear receptor subfamily 2 group C member 2 isoform X4

      UniProtKB/TrEMBL
      Q6PHZ7
    23. XM_024453739.2XP_024309507.1  nuclear receptor subfamily 2 group C member 2 isoform X9

      Conserved Domains (2) summary
      cd06952
      Location:182403
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cl02596
      Location:119
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      14950033..15051696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347716.1XP_054203691.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
    2. XM_054347714.1XP_054203689.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
    3. XM_054347721.1XP_054203696.1  nuclear receptor subfamily 2 group C member 2 isoform X3

    4. XM_054347719.1XP_054203694.1  nuclear receptor subfamily 2 group C member 2 isoform X2

      UniProtKB/TrEMBL
      Q6PHZ7
    5. XM_054347711.1XP_054203686.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
    6. XM_054347728.1XP_054203703.1  nuclear receptor subfamily 2 group C member 2 isoform X7

      UniProtKB/TrEMBL
      Q6PHZ7
    7. XM_054347720.1XP_054203695.1  nuclear receptor subfamily 2 group C member 2 isoform X3

    8. XM_054347724.1XP_054203699.1  nuclear receptor subfamily 2 group C member 2 isoform X5

      UniProtKB/TrEMBL
      A0A024R2N9, F2YGU2, Q6PHZ7
    9. XM_054347717.1XP_054203692.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
    10. XM_054347725.1XP_054203700.1  nuclear receptor subfamily 2 group C member 2 isoform X5

      UniProtKB/TrEMBL
      A0A024R2N9, F2YGU2, Q6PHZ7
    11. XM_054347713.1XP_054203688.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
    12. XM_054347729.1XP_054203704.1  nuclear receptor subfamily 2 group C member 2 isoform X7

      UniProtKB/TrEMBL
      Q6PHZ7
    13. XM_054347723.1XP_054203698.1  nuclear receptor subfamily 2 group C member 2 isoform X3

    14. XM_054347730.1XP_054203705.1  nuclear receptor subfamily 2 group C member 2 isoform X8

      UniProtKB/TrEMBL
      Q6PHZ7
    15. XM_054347727.1XP_054203702.1  nuclear receptor subfamily 2 group C member 2 isoform X6

      UniProtKB/TrEMBL
      Q6PHZ7
    16. XM_054347715.1XP_054203690.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
    17. XM_054347722.1XP_054203697.1  nuclear receptor subfamily 2 group C member 2 isoform X3

    18. XM_054347718.1XP_054203693.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
    19. XM_054347712.1XP_054203687.1  nuclear receptor subfamily 2 group C member 2 isoform X1

      UniProtKB/TrEMBL
      Q6PHZ7
    20. XM_054347726.1XP_054203701.1  nuclear receptor subfamily 2 group C member 2 isoform X5

      UniProtKB/TrEMBL
      A0A024R2N9, F2YGU2, Q6PHZ7
    21. XM_054347731.1XP_054203706.1  nuclear receptor subfamily 2 group C member 2 isoform X9