Rbms1 RNA binding motif, single stranded interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbms1provided by MGI
Official Full Name: RNA binding motif, single stranded interacting protein 1provided by MGI
Primary source: MGI:MGI:1861774
See related: Ensembl:ENSMUSG00000026970 AllianceGenome:MGI:1861774
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: YC1; MSSP-1; MSSP-2; MSSP-3; 2600014B10Rik
Summary: Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be involved in DNA replication. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human RBMS1 (RNA binding motif single stranded interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in lung adult (RPKM 26.0), ovary adult (RPKM 17.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.2; 2 34.95 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (60580537..60794224, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (60750193..60963880, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.
Title: CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.
Transcriptomic and Proteomic Analysis Reveals the Potential Role of RBMS1 in Adipogenesis and Adipocyte Metabolism.
Title: Transcriptomic and Proteomic Analysis Reveals the Potential Role of RBMS1 in Adipogenesis and Adipocyte Metabolism.
study demonstrates that miR-383 functions as a positive regulator of E2 release in ovarian granulosa cells through inhibiting expression of RBMS1 and its downstream c-Myc
Title: Transactivation of microRNA-383 by steroidogenic factor-1 promotes estradiol release from mouse ovarian granulosa cells by targeting RBMS1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rbms1 (e-PCR), detects polymorphism
- UniSTS:479237

RH80864 (e-PCR)
- UniSTS:86813

RH136033 (e-PCR)
- UniSTS:210028

RH80872 (e-PCR)
- UniSTS:90023

RH135918 (e-PCR)
- UniSTS:209915

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(U) RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RNA-binding motif, single-stranded-interacting protein 1

Names: single-stranded DNA-binding protein MSSP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001141931.1 → NP_001135403.1 RNA-binding motif, single-stranded-interacting protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus, compared to isoform 1.

Source sequence(s)

AA175245, AK145897, AK147109, AK161102

UniProtKB/TrEMBL

Q3UKR8, Q3V0L4

Conserved Domains (2) summary

cd12470
Location:53 → 138

RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1

cd12474
Location:139 → 224

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
NM_001141932.1 → NP_001135404.1 RNA-binding motif, single-stranded-interacting protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AA175245, AK145897, AK161102

Consensus CDS

CCDS50590.1

UniProtKB/TrEMBL

E9PZ21, Q3TTX8

Related

ENSMUSP00000131306.2, ENSMUST00000164147.8

Conserved Domains (2) summary

cd12470
Location:53 → 138

RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1

cd12474
Location:139 → 224

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
NM_020296.2 → NP_064692.2 RNA-binding motif, single-stranded-interacting protein 1 isoform 3

See identical proteins and their annotated locations for NP_064692.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) has a different 5' UTR and 5' coding region and lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 3) has a distinct N-terminus and a shorter C-terminus, compared to isoform 1.

Source sequence(s)

AA175245, AK147109, AK161102, BC016501

Consensus CDS

CCDS50591.1

UniProtKB/Swiss-Prot

Q3UI25, Q3UXU2, Q6PEU6, Q6PHC2, Q91W59, Q9WTK4

UniProtKB/TrEMBL

Q3UKR8, Q3V0L4

Related

ENSMUSP00000028347.7, ENSMUST00000028347.13

Conserved Domains (2) summary

cd12470
Location:55 → 140

RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1

cd12474
Location:141 → 226

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

60580537..60794224 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499940.2 → XP_006500003.1 RNA-binding motif, single-stranded-interacting protein 1 isoform X1

UniProtKB/TrEMBL

Q3TTX8

Conserved Domains (2) summary

cd12470
Location:55 → 140

RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1

cd12474
Location:141 → 226

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
XM_030251908.1 → XP_030107768.1 RNA-binding motif, single-stranded-interacting protein 1 isoform X6

UniProtKB/TrEMBL

Q3UKR8, Q3V0L4

Conserved Domains (2) summary

cd12470
Location:55 → 140

RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1

cd12474
Location:141 → 226

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
XM_017319146.1 → XP_017174635.1 RNA-binding motif, single-stranded-interacting protein 1 isoform X3

UniProtKB/TrEMBL

Q3TTX8

Conserved Domains (2) summary

cd12470
Location:55 → 140

RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1

cd12474
Location:141 → 226

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
XM_030251910.1 → XP_030107770.1 RNA-binding motif, single-stranded-interacting protein 1 isoform X8

UniProtKB/TrEMBL

Q3UKR8, Q3V0L4

Conserved Domains (2) summary

cd12470
Location:35 → 120

RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1

cd12474
Location:121 → 206

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
XM_006499942.3 → XP_006500005.1 RNA-binding motif, single-stranded-interacting protein 1 isoform X5

UniProtKB/TrEMBL

Q3TTX8

Conserved Domains (2) summary

cd12470
Location:35 → 120

RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1

cd12474
Location:121 → 206

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
XM_030251909.2 → XP_030107769.1 RNA-binding motif, single-stranded-interacting protein 1 isoform X7

UniProtKB/TrEMBL

Q3UKR8, Q3V0L4

Conserved Domains (2) summary

cd12470
Location:53 → 138

RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1

cd12474
Location:139 → 224

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
XM_030251907.2 → XP_030107767.1 RNA-binding motif, single-stranded-interacting protein 1 isoform X4

UniProtKB/TrEMBL

Q3TTX8

Conserved Domains (2) summary

cd12470
Location:53 → 138

RRM1_MSSP1; RNA recognition motif 1 in vertebrate single-stranded DNA-binding protein MSSP-1

cd12474
Location:139 → 224

RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
XM_036162420.1 → XP_036018313.1 RNA-binding motif, single-stranded-interacting protein 1 isoform X2

UniProtKB/TrEMBL

Q3TTX8

Conserved Domains (2) summary

cd12470
Location:45 → 130

RRM1_MSSP1; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-1

cd12473
Location:131 → 215

RRM2_MSSP1; RNA recognition motif 2 (RRM2) found in vertebrate single-stranded DNA-binding protein MSSP-1