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    TPT1-AS1 TPT1 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 100190939, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TPT1-AS1provided by HGNC
    Official Full Name
    TPT1 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:43686
    See related
    AllianceGenome:HGNC:43686
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Biomarker of malignant astrocytoma. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in stomach (RPKM 54.2), salivary gland (RPKM 49.4) and 23 other tissues See more
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    Genomic context

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    See TPT1-AS1 in Genome Data Viewer
    Location:
    13q14.13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (45341345..45391483)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (44561592..44610617)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (45915480..45965618)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:45914388-45915177 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5315 Neighboring gene uncharacterized LOC124903169 Neighboring gene small nucleolar RNA, H/ACA box 31B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:45916757-45917544 Neighboring gene small nucleolar RNA, H/ACA box 31 Neighboring gene tumor protein, translationally-controlled 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:45941608-45942114 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:45944664-45945164 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:45945165-45945665 Neighboring gene Sharpr-MPRA regulatory region 12652 Neighboring gene reticulocalbin 1 pseudogene 2 Neighboring gene solute carrier family 25 member 30 Neighboring gene Sharpr-MPRA regulatory region 15232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5316 Neighboring gene SLC25A30 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7680 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:45996790-45997291 Neighboring gene peptidylprolyl isomerase A pseudogene 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Clinicopathological and prognostic value of lncRNA TPT1-AS1 in cancer: A systematic review study and meta-analysis. Rastad H, et al. Pathol Res Pract, 2023 May. PMID 37004278
    2. A review of literature: role of long noncoding RNA TPT1-AS1 in human diseases. Li Y, et al. Clin Transl Oncol, 2023 Feb. PMID 36112261
    3. Long Non-coding RNA TPT1-AS1 Suppresses APC Transcription in a STAT1-Dependent Manner to Increase the Stemness of Colorectal Cancer Stem Cells. Chen B, et al. Mol Biotechnol, 2022 May. PMID 35022996
    4. [Effects of tumor protein translation control antisense RNA1 on radiosensitivity, proliferation, migration and invasion of hepatocellular carcinoma cells by targeting miR-30c-5p]. Zhai JJ, et al. Zhonghua Zhong Liu Za Zhi, 2021 Oct 23. PMID 34695895
    5. lncRNA TPT1‑AS1 knockdown inhibits liver cancer cell proliferation, migration and invasion. Li H, et al. Mol Med Rep, 2021 Nov. PMID 34498708, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinicopathological and prognostic value of lncRNA TPT1-AS1 in cancer: A systematic review study and meta-analysis.
      Title: Clinicopathological and prognostic value of lncRNA TPT1-AS1 in cancer: A systematic review study and meta-analysis.
    2. A review of literature: role of long noncoding RNA TPT1-AS1 in human diseases.
      Title: A review of literature: role of long noncoding RNA TPT1-AS1 in human diseases.
    3. Positive feedback regulation of lncRNA TPT1-AS1 and ITGB3 promotes cell growth and metastasis in pancreatic cancer.
      Title: Positive feedback regulation of lncRNA TPT1-AS1 and ITGB3 promotes cell growth and metastasis in pancreatic cancer.
    4. Long Non-coding RNA TPT1-AS1 Suppresses APC Transcription in a STAT1-Dependent Manner to Increase the Stemness of Colorectal Cancer Stem Cells.
      Title: Long Non-coding RNA TPT1-AS1 Suppresses APC Transcription in a STAT1-Dependent Manner to Increase the Stemness of Colorectal Cancer Stem Cells.
    5. Overexpression of IncRNA TPT1-AS1 Suppresses Hepatocellular Carcinoma Cell Proliferation by Downregulating CDK2.
      Title: Overexpression of IncRNA TPT1-AS1 Suppresses Hepatocellular Carcinoma Cell Proliferation by Downregulating CDK2.
    6. lncRNA TPT1AS1 knockdown inhibits liver cancer cell proliferation, migration and invasion.
      Title: lncRNA TPT1‑AS1 knockdown inhibits liver cancer cell proliferation, migration and invasion.
    7. LncRNA TPT1-AS1 Sponges miR-23a-5p in Glioblastoma to Promote Cancer Cell Proliferation.
      Title: LncRNA TPT1-AS1 Sponges miR-23a-5p in Glioblastoma to Promote Cancer Cell Proliferation.
    8. [Effects of tumor protein translation control antisense RNA1 on radiosensitivity, proliferation, migration and invasion of hepatocellular carcinoma cells by targeting miR-30c-5p].
      Title: [Effects of tumor protein translation control antisense RNA1 on radiosensitivity, proliferation, migration and invasion of hepatocellular carcinoma cells by targeting miR-30c-5p].
    9. Knockdown of TPT1-AS1 inhibits cell proliferation, cell cycle G1/S transition, and epithelial-mesenchymal transition in gastric cancer.
      Title: Knockdown of TPT1-AS1 inhibits cell proliferation, cell cycle G1/S transition, and epithelial-mesenchymal transition in gastric cancer.
    10. Long noncoding RNA TPT1-AS1 promotes the progression and metastasis of colorectal cancer by upregulating the TPT1-mediated FAK and JAK-STAT3 signalling pathways.
      Title: Long noncoding RNA TPT1-AS1 promotes the progression and metastasis of colorectal cancer by upregulating the TPT1-mediated FAK and JAK-STAT3 signalling pathways.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • TPT1 antisense RNA 1 (non-protein coding)

    Clone Names

    • FLJ42341, FLJ45662

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024458.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF318337, AL138963

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      45341345..45391483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      44561592..44610617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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