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    Pgant1 Polypeptide N-Acetylgalactosaminyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36717, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgant1provided by FlyBase
    Official Full Name
    Polypeptide N-Acetylgalactosaminyltransferase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0034025
    Locus tag
    Dmel_CG8182
    See related
    AllianceGenome:FB:FBgn0034025
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8182; Dmel\CG8182; GalNAc-T1; pgant1
    Summary
    Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in oligosaccharide biosynthetic process. Predicted to be active in Golgi apparatus. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; gut section; and imaginal disc. Orthologous to human GALNT3 (polypeptide N-acetylgalactosaminyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pgant1 in Genome Data Viewer
    Location:
    52A6-52A6; 2-74 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15511710..15515597)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11399215..11403102)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 52c Neighboring gene Ionotropic receptor 52d Neighboring gene Kinesin heavy chain 73 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family is spatially and temporally regulated during Drosophila development. Tian E, et al. Glycobiology, 2006 Feb. PMID 16251381
    2. Functional characterization and expression analysis of members of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family from Drosophila melanogaster. Ten Hagen KG, et al. J Biol Chem, 2003 Sep 12. PMID 12829714
    3. Multiple members of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family are essential for viability in Drosophila. Tran DT, et al. J Biol Chem, 2012 Feb 17. PMID 22157008, Free PMC Article
    4. Dissecting the biological role of mucin-type O-glycosylation using RNA interference in Drosophila cell culture. Zhang L, et al. J Biol Chem, 2010 Nov 5. PMID 20807760, Free PMC Article
    5. An O-glycosyltransferase promotes cell adhesion during development by influencing secretion of an extracellular matrix integrin ligand. Zhang L, et al. J Biol Chem, 2010 Jun 18. PMID 20371600, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi stack NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polypeptide N-Acetylgalactosaminyltransferase 1
    Names
    CG8182-PA
    CG8182-PB
    CG8182-PC
    GalNAc-T1
    N-acetylgalactosaminyltransferase
    Pgant1-PA
    Pgant1-PB
    Pgant1-PC
    polypeptide GalNAc transferase 1
    NP_001286461.1
    NP_611043.1
    NP_725472.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15511710..15515597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137199.3 → NP_611043.1  polypeptide N-Acetylgalactosaminyltransferase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611043.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E964, Q6WV20, Q9V7C8
      Related
      FBpp0086464
      Conserved Domains (4) summary
      cd02510
      Location:152 → 461
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:147 → 426
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:481 → 599
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:474 → 597
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. NM_166099.2 → NP_725472.1  polypeptide N-Acetylgalactosaminyltransferase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725472.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E964, Q6WV20, Q9V7C8
      Related
      FBpp0086465
      Conserved Domains (4) summary
      cd02510
      Location:152 → 461
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:147 → 426
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:481 → 599
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:474 → 597
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    3. NM_001299532.1 → NP_001286461.1  polypeptide N-Acetylgalactosaminyltransferase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286461.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFI4
      Conserved Domains (3) summary
      cd02510
      Location:4 → 244
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:264 → 382
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:257 → 380
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFI4 A0A0B4LFI4
    Q6WV20.2 Q6WV20

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