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    VCL vinculin [ Gallus gallus (chicken) ]

    Gene ID: 396422, updated on 3-Dec-2024

    Summary

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    Symbol
    VCLprovided by CGNC
    Full Name
    vinculinprovided by CGNC
    Primary source
    CGNC:3778
    See related
    Ensembl:ENSGALG00010022474
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    VINC1
    Orthologs
    human mouse all
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    Genomic context

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    See VCL in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (16171073..16227197, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (16156750..16212942, complement)

    Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121111130 Neighboring gene adenosine kinase Neighboring gene adaptor related protein complex 3 mu 1 subunit Neighboring gene uncharacterized LOC124418049 Neighboring gene uncharacterized LOC124418392 Neighboring gene uncharacterized LOC121111131

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of an actin binding surface on vinculin that mediates mechanical cell and focal adhesion properties. Thompson PM, et al. Structure, 2014 May 6. PMID 24685146, Free PMC Article
    2. Further characterisation of the talin-binding site in the cytoskeletal protein vinculin. Gilmore AP, et al. J Cell Sci, 1992 Nov. PMID 1478968
    3. Chicken vinculin and meta-vinculin are derived from a single gene by alternative splicing of a 207-base pair exon unique to meta-vinculin. Byrne BJ, et al. J Biol Chem, 1992 Jun 25. PMID 1618784
    4. Primary sequence and domain structure of chicken vinculin. Price GJ, et al. Biochem J, 1989 Apr 15. PMID 2497736, Free PMC Article
    5. Identification of a talin binding site in the cytoskeletal protein vinculin. Jones P, et al. J Cell Biol, 1989 Dec. PMID 2512301, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VASP phosphorylation at Ser(157) mediates its localization at the membrane, but that VASP Ser(157) phosphorylation and membrane localization are not sufficient to activate its actin catalytic activity
      Title: Vasodilator-stimulated phosphoprotein (VASP) regulates actin polymerization and contraction in airway smooth muscle by a vinculin-dependent mechanism.
    2. The importance of the actin-binding site in vinculin, which provide the molecular basis for elucidating additional roles of this interaction, including actin-induced conformational changes that promote actin bundling.
      Title: Identification of an actin binding surface on vinculin that mediates mechanical cell and focal adhesion properties.
    3. Data show that alphaE-catenin D3 binds strongly to vinculin, whereas larger fragments and full-length alphaE-catenin bind approximately 1,000-fold more weakly.
      Title: αE-catenin is an autoinhibited molecule that coactivates vinculin.
    4. The vinculin C-terminal hairpin mediates F-actin bundle formation, focal adhesion, and cell mechanical properties.
      Title: The vinculin C-terminal hairpin mediates F-actin bundle formation, focal adhesion, and cell mechanical properties.
    5. ACh stimulation regulates vinculin activation in tracheal smooth muscle via RhoA; vinculin activation facilitates connections between actin filaments and talin-integrin adhesion complexes and mediates the initiation of actin polymerization
      Title: Activation of vinculin induced by cholinergic stimulation regulates contraction of tracheal smooth muscle tissue.
    6. vinculin can link adhesion plaques to the cytoskeleton by initiating the formation of bundled actin filaments or by remodeling existing filaments
      Title: Vinculin nucleates actin polymerization and modifies actin filament structure.
    7. Lipid binding to the tail domain of vinculin: specificity and the role of the N and C termini
      Title: Lipid binding to the tail domain of vinculin: specificity and the role of the N and C termini.
    8. role of pH on vinculin tail domain structure and self-association
      Title: Vinculin tail conformation and self-association is independent of pH and H906 protonation.
    9. A critical region of s-alpha-actinin that affects the width and integrity of the Z-line. This region is at least involved in the interaction with vinculin.
      Title: Sarcomeric-alpha-actinin defective in vinculin-binding causes Z-line expansion and nemaline-like body formation in cultured chick myotubes.
    10. study investigated the effect of force on the interaction between talin & vinculin; in the talin-vinculin system, molecular mechanotransduction can occur by protein binding after exposure of buried binding sites
      Title: Stretching single talin rod molecules activates vinculin binding.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vinculin
    Names
    meta-vinculin
    metavinculin
    vinc 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205441.3 → NP_990772.1  vinculin

      See identical proteins and their annotated locations for NP_990772.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000231
      UniProtKB/TrEMBL
      A0A8V0ZQZ7
      Related
      ENSGALP00010033043.1, ENSGALT00010054689.1
      Conserved Domains (1) summary
      pfam01044
      Location:66 → 1066
      Vinculin; Vinculin family

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      16171073..16227197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015288203.3 → XP_015143689.1  vinculin isoform X2

      UniProtKB/Swiss-Prot
      P12003, Q91024
      UniProtKB/TrEMBL
      A0A8V0ZQZ7
      Related
      ENSGALP00010033042.1, ENSGALT00010054688.1
      Conserved Domains (1) summary
      pfam01044
      Location:66 → 1135
      Vinculin; Vinculin family

    2. XM_015288200.4 → XP_015143686.1  vinculin isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZI80, A0A8V0ZQZ7
      Conserved Domains (1) summary
      pfam01044
      Location:66 → 1067
      Vinculin; Vinculin family

    3. XM_040702308.2 → XP_040558242.1  vinculin isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZQZ7

    RNA

    1. XR_005860609.2 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      16156750..16212942 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046919961.1 → XP_046775917.1  vinculin isoform X2

      UniProtKB/Swiss-Prot
      P12003, Q91024
      UniProtKB/TrEMBL
      A0A8V0ZQZ7

    2. XM_046919962.1 → XP_046775918.1  vinculin isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZI80, A0A8V0ZQZ7

    3. XM_046919960.1 → XP_046775916.1  vinculin isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZQZ7

    RNA

    1. XR_006934989.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12003.4 GenPept UniProtKB/Swiss-Prot:P12003

    Gene LinkOut

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