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    TARP TCR gamma alternate reading frame protein [ Homo sapiens (human) ]

    Gene ID: 445347, updated on 27-Nov-2024

    Summary

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    Gene symbol
    TARP
    Gene description
    TCR gamma alternate reading frame protein
    See related
    Ensembl:ENSG00000289746 MIM:609642
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD3G
    Summary
    In some non-lymphoid tissues, the unrearranged T cell receptor gamma (TRG@) locus is expressed. The resulting transcript contains a subset of the TRG@ gene segments and is shorter than TRG@ transcripts expressed in lymphoid tissues. This RefSeq record represents the unrearranged TRG@ locus transcript; the complete TRG@ locus is represented by the genomic RefSeq NG_001336. The transcript represented by this RefSeq has two open reading frames (ORFs) that encode different proteins. The downstream ORF is in the same frame as TRG@ and its protein product is similar to TRG@ proteins. The upstream ORF uses a different reading frame and encodes a novel protein. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in prostate (RPKM 38.4), bone marrow (RPKM 13.6) and 3 other tissues See more
    Orthologs
    all
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    Genomic context

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    See TARP in Genome Data Viewer
    Location:
    7p14.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (38259643..38273636, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (38416644..38430635, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (38299244..38313237, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene T cell receptor gamma locus Neighboring gene T cell receptor gamma joining 2 Neighboring gene T cell receptor gamma joining P2 Neighboring gene T cell receptor gamma constant 1 Neighboring gene T cell receptor gamma joining 1 Neighboring gene T cell receptor gamma joining P Neighboring gene T cell receptor gamma joining P1 Neighboring gene T cell receptor gamma variable 11 (non-functional)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment. Depreter B, et al. Haematologica, 2020 May. PMID 31371409, Free PMC Article
    2. Further evidence for a gamma/delta T cell receptor-mediated TCT.1/CD48 recognition. Mami-Chouaib F, et al. J Immunol, 1991 Nov 1. PMID 1655899
    3. Arrangements and rearrangements of the human T-cell receptor gamma gene. Pelicci PG, et al. Ann N Y Acad Sci, 1987. PMID 2964218
    4. Characterization of a third form of the human T cell receptor gamma/delta. Hochstenbach F, et al. J Exp Med, 1988 Aug 1. PMID 3261778, Free PMC Article
    5. Human TCR-gamma/delta alloreactive response to HLA-DR molecules. Comparison with response of TCR-alpha/beta. Flament C, et al. J Immunol, 1994 Oct 1. PMID 8089476

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High expression of TARP correlates with inferior FLT3 mutations in non-adolescents and young adults with acute myeloid leukaemia.
      Title: High expression of TARP correlates with inferior FLT3 mutations in non-adolescents and young adults with acute myeloid leukaemia.
    2. The expression of TARP and KRT5 was correlated with the progress of endometrial cancer
      Title: Value of T cell receptor gamma alternate reading frame protein and keratin 5 in endometrial carcinoma.
    3. The results of this study found decreased transcript expression of TARP gamma-8 in schizophrenia.
      Title: Transmembrane AMPA receptor regulatory protein (TARP) dysregulation in anterior cingulate cortex in schizophrenia.
    4. T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells.
      Title: T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells.
    5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration.
    6. up-regulated in prostate cancer tissue
      Title: Antibody responses to galectin-8, TARP and TRAP1 in prostate cancer patients treated with a GM-CSF-secreting cellular immunotherapy.
    7. A prognostic value of TARP in prostate cancer could not be found.
      Title: Diagnostic and prognostic value of T-cell receptor gamma alternative reading frame protein (TARP) expression in prostate cancer.
    8. Intracellular protein degradation and endosomal acidification were significantly delayed in gammadelta T-antigen-presenting cells compared with human monocyte-derived dendritic cells(moDCs).
      Title: Prolonged antigen survival and cytosolic export in cross-presenting human gammadelta T cells.
    9. Nine peptides and two proteins were identified for TCRgammadelta, including human mutS homolog 2 (hMSH2) and heat shock protein (HSP) 60.
      Title: Identification of human T cell receptor gammadelta-recognized epitopes/proteins via CDR3delta peptide-based immunobiochemical strategy.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    T-cell receptor gamma alternate reading frame protein
    Names
    TCR- gamma V-IV
    antigen, T-cell receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029035.1 RefSeqGene

      Range
      5001..19005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    2. NG_001336.2 

      Range
      100301..114305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001003799.2 → NP_001003799.1  T-cell receptor gamma alternate reading frame protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses the upstream ORF. The resulting protein (isoform 1) localizes to the outer mitochondrial membrane.
      Source sequence(s)
      AF151103, BF674593
      Consensus CDS
      CCDS94087.1
      UniProtKB/Swiss-Prot
      A2JGV3
      Related
      ENSP00000513628.1, ENST00000698248.1

    2. NM_001003806.2 → NP_001003806.1  T-cell receptor gamma alternate reading frame protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses the downstream ORF. The resulting protein (isoform 2) is similar to but shorter than TRG@ proteins, since this transcript does not include any variable regions.
      Source sequence(s)
      AF151103, BF674593
      UniProtKB/TrEMBL
      Q0VGM3
      Conserved Domains (1) summary
      cl11960
      Location:1 → 44
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      38259643..38273636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      38416644..38430635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2JGV3.1 GenPept UniProtKB/Swiss-Prot:A2JGV3

    Gene LinkOut

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