ALOX15 arachidonate 15-lipoxygenase [Homo sapiens (human)] - Gene

Summary

Official Symbol: ALOX15provided by HGNC
Official Full Name: arachidonate 15-lipoxygenaseprovided by HGNC
Primary source: HGNC:HGNC:433
See related: Ensembl:ENSG00000161905 MIM:152392; AllianceGenome:HGNC:433
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LOG15; 12-LOX; 15-LOX; 15-LOX-1
Summary: This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
Expression: Biased expression in lung (RPKM 5.0), small intestine (RPKM 1.7) and 11 other tissues See more
Orthologs: all
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Genomic context

Location:: 17p13.2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (4630919..4641678, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (4520655..4531416, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (4534214..4544973, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identifying ALOX15-initiated lipid peroxidation increases susceptibility to ferroptosis in asthma epithelial cells.
Title: Identifying ALOX15-initiated lipid peroxidation increases susceptibility to ferroptosis in asthma epithelial cells.
Association between arachidonate lipoxygenase 15,c.-292 C > T gene polymorphism and non-cystic fibrosis bronchiectasis in children: a pilot study on the effects on airway lipoxin A4 and disease phenotype.
Title: Association between arachidonate lipoxygenase 15,c.-292 C > T gene polymorphism and non-cystic fibrosis bronchiectasis in children: a pilot study on the effects on airway lipoxin A4 and disease phenotype.
Epigenetic regulation of 15-lipoxygenase-1 expression in human chondrocytes by promoter methylation.
Title: Epigenetic regulation of 15-lipoxygenase-1 expression in human chondrocytes by promoter methylation.
A review on the relationship between Arachidonic acid 15-Lipoxygenase (ALOX15) and diabetes mellitus.
Title: A review on the relationship between Arachidonic acid 15-Lipoxygenase (ALOX15) and diabetes mellitus.
15-lipoxygenase and cyclooxygenase expression profile and their related modulators in COVID-19 infection.
Title: 15-lipoxygenase and cyclooxygenase expression profile and their related modulators in COVID-19 infection.
CircRNA 06209 inhibits cataract development by sponging miR-6848-5p and regulating ALOX15 expression.
Title: CircRNA 06209 inhibits cataract development by sponging miR-6848-5p and regulating ALOX15 expression.
Photothermal lipolysis accelerates ECM production via macrophage-derived ALOX15-mediated p38 MAPK activation in fibroblasts.
Title: Photothermal lipolysis accelerates ECM production via macrophage-derived ALOX15-mediated p38 MAPK activation in fibroblasts.
Poly(rC)-binding protein 1 represses ferritinophagy-mediated ferroptosis in head and neck cancer.
Title: Poly(rC)-binding protein 1 represses ferritinophagy-mediated ferroptosis in head and neck cancer.
15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation.
Title: 15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation.
Characterization of Mice Ubiquitously Overexpressing Human 15-Lipoxygenase-1: Effect of Diabetes on Peripheral Neuropathy and Treatment with Menhaden Oil.
Title: Characterization of Mice Ubiquitously Overexpressing Human 15-Lipoxygenase-1: Effect of Diabetes on Peripheral Neuropathy and Treatment with Menhaden Oil.

Submit: New GeneRIF Correction See all GeneRIFs (174)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

STS-U88317 (e-PCR)
- UniSTS:32281

SHGC-35280 (e-PCR)
- UniSTS:74314

ALOX15-A611G (e-PCR)
- UniSTS:240885

ALOX15-F4-R4 (e-PCR)
- UniSTS:240886

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables arachidonate 12(S)-lipoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate 12(S)-lipoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonate 15-lipoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate 15-lipoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonate 15-lipoxygenase activity	NAS Non-traceable Author Statement more info	PubMed
enables arachidonate 15-lipoxygenase activity	TAS Traceable Author Statement more info
enables iron ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables linoleate 13S-lipoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables linoleate 13S-lipoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic cell clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in arachidonate metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interleukin-13	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in hepoxilin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in linoleic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoxin A4 biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipoxygenase pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoxygenase pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in lipoxygenase pathway	TAS Traceable Author Statement more info
involved_in long-chain fatty acid biosynthetic process	TAS Traceable Author Statement more info
involved_in negative regulation of adaptive immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in ossification	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylethanolamine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of actin filament polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell-substrate adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of engulfment of apoptotic cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of peroxisome proliferator activated receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in wound healing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: polyunsaturated fatty acid lipoxygenase ALOX15

Names: 12/15-lipoxygenase; 15-LOX type 1; 15-lipooxygenase-1; 15-lipoxygenase type 1; arachidonate 12-lipoxygenase, leukocyte-type; arachidonate omega-6 lipoxygenase; hepoxilin A3 synthase Alox15; linoleate 13S-lipoxygenase

NP_001131.3

EC 1.13.11.12

EC 1.13.11.31

EC 1.13.11.33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001140.5 → NP_001131.3 polyunsaturated fatty acid lipoxygenase ALOX15

See identical proteins and their annotated locations for NP_001131.3

Status: REVIEWED

Source sequence(s)

AK312557, BC029032, M23892

Consensus CDS

CCDS11049.1

UniProtKB/Swiss-Prot

A8K2P4, B7ZA11, P16050, Q8N6R7, Q99657

UniProtKB/TrEMBL

B2R6F7

Related

ENSP00000293761.3, ENST00000293761.8

Conserved Domains (2) summary

cd01753
Location:2 → 111

PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...

pfam00305
Location:219 → 653

Lipoxygenase; Lipoxygenase