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    Nol8 nucleolar protein 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361221, updated on 9-Dec-2024

    Summary

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    Symbol
    Nol8provided by RGD
    Full Name
    nucleolar protein 8provided by RGD
    Primary source
    RGD:1309551
    See related
    EnsemblRapid:ENSRNOG00000046968 AllianceGenome:RGD:1309551
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in protein localization to nucleolus and rRNA processing. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in chromosome. Predicted to be active in nucleolus. Orthologous to human NOL8 (nucleolar protein 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 164.5), Spleen (RPKM 86.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nol8 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (15196881..15220265, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (14990394..15013784, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (14565794..14589154, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA24 Neighboring gene isoleucyl-tRNA synthetase 1 Neighboring gene small nucleolar RNA SNORA84 Neighboring gene centromere protein P Neighboring gene osteoglycin Neighboring gene osteomodulin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of NOL8, a nucleolar protein containing an RNA recognition motif (RRM), which was overexpressed in diffuse-type gastric cancer. Jinawath N, et al. Cancer Sci, 2004 May. PMID 15132771, Free PMC Article
    2. A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. Sekiguchi T, et al. J Biol Chem, 2004 Feb 27. PMID 14660641
    3. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. Sekiguchi T, et al. Nucleic Acids Res, 2006. PMID 16963496, Free PMC Article
    4. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395573.1 → NP_001382502.1  nucleolar protein 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6J6V5
      Related
      ENSRNOP00000067842.3, ENSRNOT00000073035.3
      Conserved Domains (1) summary
      cd12226
      Location:27 → 106
      RRM_NOL8; RNA recognition motif (RRM) found in nucleolar protein 8 (NOL8) and similar proteins

    2. NM_001395574.1 → NP_001382503.1  nucleolar protein 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      M0RDX9
      Conserved Domains (1) summary
      smart00360
      Location:3 → 78
      RRM; RNA recognition motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      15196881..15220265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276567.1 → XP_063132637.1  nucleolar protein 8 isoform X2

      UniProtKB/TrEMBL
      A6J6V5

    2. XM_063276566.1 → XP_063132636.1  nucleolar protein 8 isoform X1

      UniProtKB/TrEMBL
      A6J6V5

    3. XM_063276568.1 → XP_063132638.1  nucleolar protein 8 isoform X3

      UniProtKB/TrEMBL
      A6J6V5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108408.1: Suppressed sequence

      Description
      NM_001108408.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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