Smr3b submaxillary gland androgen regulated protein 3B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Smr3bprovided by RGD
Official Full Name: submaxillary gland androgen regulated protein 3Bprovided by RGD
Primary source: RGD:3953
See related: EnsemblRapid:ENSRNOG00000001942 AllianceGenome:RGD:3953
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Arp; Smr1; Smr1g; Vcsa1; P2-VA1; RATSMR1A
Summary: Enables endopeptidase inhibitor activity. Involved in cellular response to lipopolysaccharide; negative regulation of peptidase activity; and regulation of sensory perception of pain. Located in extracellular region. Orthologous to human SMR3B (submaxillary gland androgen regulated protein 3B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 13.8), Spleen (RPKM 10.5) and 3 other tissues See more
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Genomic context

Location:: 14p22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (20067850..20072520, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (19783815..19788557, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (21490216..21709077, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

When rat corporal smooth muscle cells were treated with CoCl2 or low oxygen tension to mimic hypoxia, Vcsa1 was increased tenfold.
Title: Opiorphin is a master regulator of the hypoxic response in corporal smooth muscle cells.
correlation of erectile function, testosterone levels and Vcsa1 expression in orchiectomized rats and controls
Title: Testosterone regulates erectile function and Vcsa1 expression in the corpora of rats.
Autonomic nervous system regulates secretion of anti-inflammatory prohormone SMR1 from rat salivary glands.
Title: Autonomic nervous system regulates secretion of anti-inflammatory prohormone SMR1 from rat salivary glands.
Sialorphin increased, in a dose-related manner, the occurrence of intromissions across the successive ejaculatory sequences.
Title: The endogenous androgen-regulated sialorphin modulates male rat sexual behavior.
Sialorphin protects endogenous enkephalins released after nociceptive stimuli by inhibiting neprilysin in vivo. It is a natural systemically active regulator of NEP activity & is a physiological modulator of pain perception after injury
Title: Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.

Submit: New GeneRIF Correction

General gene information

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Markers

D14Hmgc4 (e-PCR)
- UniSTS:463388

D14Wox13 (e-PCR)
- UniSTS:118125

D14Wox17 (e-PCR)
- UniSTS:517778

AW533278 (e-PCR)
- UniSTS:245971

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of peptidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of sensory perception of pain	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SMR1 protein

Names: VCS-alpha 1; Variable coding sequence A1 (androgen regulated protein (SMR1) gene); androgen regulated protein; sialorphin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012684.4 → NP_036816.4 SMR1 protein precursor

See identical proteins and their annotated locations for NP_036816.4

Status: VALIDATED

Source sequence(s)

CB769246, JAXUCZ010000014

UniProtKB/Swiss-Prot

P13432

Related

ENSRNOP00000073073.2, ENSRNOT00000087477.3

Conserved Domains (1) summary

pfam15621
Location:1 → 108

PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

20067850..20072520 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091622.2 → XP_038947550.1 SMR1 protein isoform X1

UniProtKB/TrEMBL

A0A0G2K4K1, A6KKK3

Conserved Domains (1) summary

pfam15621
Location:1 → 108

PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family