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    Asgr2 asialoglycoprotein receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29403, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Asgr2provided by RGD
    Official Full Name
    asialoglycoprotein receptor 2provided by RGD
    Primary source
    RGD:2161
    See related
    EnsemblRapid:ENSRNOG00000030726 AllianceGenome:RGD:2161
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable D-mannose binding activity; fucose binding activity; and pattern recognition receptor activity. Involved in bone mineralization. Predicted to be located in endoplasmic reticulum quality control compartment and perinuclear region of cytoplasm. Predicted to be active in external side of plasma membrane. Orthologous to human ASGR2 (asialoglycoprotein receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 897.1) and Heart (RPKM 34.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Asgr2 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55320082..55333294)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54821407..54834624)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56710446..56723608)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA threonine (anticodon AGU) 28 Neighboring gene SEC61 translocon subunit gamma like 5 Neighboring gene C-type lectin domain containing 10A Neighboring gene solute carrier family 16, member 13 Neighboring gene solute carrier family 16, member 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats. Alam I, et al. Funct Integr Genomics, 2010 Mar. PMID 19841953, Free PMC Article
    2. Molecular cloning of rat sperm galactosyl receptor, a C-type lectin with in vitro egg binding activity. Rivkin E, et al. Mol Reprod Dev, 2000 Jul. PMID 10862008
    3. Primary structure of the rat liver asialoglycoprotein receptor. Structural evidence for multiple polypeptide species. Drickamer K, et al. J Biol Chem, 1984 Jan 25. PMID 6319386
    4. Major and minor forms of the rat liver asialoglycoprotein receptor are independent galactose-binding proteins. Primary structure and glycosylation heterogeneity of minor receptor forms. Halberg DF, et al. J Biol Chem, 1987 Jul 15. PMID 3597443
    5. Identification and characterization of cDNA clones encoding two homologous proteins that are part of the asialoglycoprotein receptor. McPhaul M, et al. Mol Cell Biol, 1987 May. PMID 3600647, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC108546

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-mannose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fucose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pattern recognition receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in bone mineralization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum quality control compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    asialoglycoprotein receptor 2
    Names
    ASGP-R 2
    ASGPR 2
    HL-2
    RHL-2
    hepatic lectin 2, RHL2
    hepatic lectin R2/3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017189.3 → NP_058885.1  asialoglycoprotein receptor 2

      See identical proteins and their annotated locations for NP_058885.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P08290, Q5M8C9
      UniProtKB/TrEMBL
      A6HG21
      Conserved Domains (2) summary
      cd03590
      Location:170 → 295
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:29 → 162
      Lectin_N; Hepatic lectin, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55320082..55333294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246676.5 → XP_006246738.1  asialoglycoprotein receptor 2 isoform X1

      See identical proteins and their annotated locations for XP_006246738.1

      UniProtKB/Swiss-Prot
      P08290, Q5M8C9
      UniProtKB/TrEMBL
      A6HG21
      Related
      ENSRNOP00000060474.1, ENSRNOT00000065370.5
      Conserved Domains (2) summary
      cd03590
      Location:170 → 295
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:29 → 162
      Lectin_N; Hepatic lectin, N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08290.4 GenPept UniProtKB/Swiss-Prot:P08290

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