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    Wdr7 WD repeat domain 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 66031, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr7provided by RGD
    Official Full Name
    WD repeat domain 7provided by RGD
    Primary source
    RGD:619836
    See related
    EnsemblRapid:ENSRNOG00000018387 AllianceGenome:RGD:619836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wd7; Trag
    Summary
    Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Is active in synaptic vesicle. Orthologous to human WDR7 (WD repeat domain 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 325.9), Thymus (RPKM 206.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdr7 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (59435733..59718800)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (57165482..57448568)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (59096636..59396312)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482983 Neighboring gene thioredoxin-like 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108348800 Neighboring gene ribosomal protein L31 like 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel rabconnectin-3-binding protein that directly binds a GDP/GTP exchange protein for Rab3A small G protein implicated in Ca(2+)-dependent exocytosis of neurotransmitter. Kawabe H, et al. Genes Cells, 2003 Jun. PMID 12786944
    2. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    3. Physiological Tau Interactome in Brain and Its Link to Tauopathies. Sinsky J, et al. J Proteome Res, 2020 Jun 5. PMID 32357304
    4. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article
    5. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WD repeat-containing protein 7
    Names
    TGF-beta resistance-associated protein TRAG
    rabconnectin-3beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395078.1 → NP_001382007.1  WD repeat-containing protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I5ZVH0, A6IXN0
      Conserved Domains (3) summary
      COG2319
      Location:19 → 199
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:22 → 62
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:407 → 594
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_023975.2 → NP_076465.1  WD repeat-containing protein 7 isoform 1

      See identical proteins and their annotated locations for NP_076465.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      Q920I8, Q9ERH3
      UniProtKB/TrEMBL
      A0A8I5ZVH0, A6IXM9
      Related
      ENSRNOP00000025325.3, ENSRNOT00000025325.5
      Conserved Domains (3) summary
      COG2319
      Location:341 → 592
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:22 → 62
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:407 → 594
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      59435733..59718800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601032.3 → XP_017456521.1  WD repeat-containing protein 7 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZVH0

    2. XM_063277569.1 → XP_063133639.1  WD repeat-containing protein 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZVH0, A6IXN0
      Related
      ENSRNOP00000082010.2, ENSRNOT00000110066.2

    3. XM_063277568.1 → XP_063133638.1  WD repeat-containing protein 7 isoform X1

      UniProtKB/Swiss-Prot
      Q920I8, Q9ERH3
      UniProtKB/TrEMBL
      A0A8I5ZVH0, A6IXM9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERH3.1 GenPept UniProtKB/Swiss-Prot:Q9ERH3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials