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    Slc6a3 solute carrier family 6 member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24898, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc6a3provided by RGD
    Official Full Name
    solute carrier family 6 member 3provided by RGD
    Primary source
    RGD:3715
    See related
    EnsemblRapid:ENSRNOG00000017302 AllianceGenome:RGD:3715
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dat1
    Summary
    Enables several functions, including amine binding activity; enzyme binding activity; and sodium:chloride symporter activity. Involved in several processes, including dopamine transport; response to cAMP; and response to ethanol. Located in neuron projection and plasma membrane. Is active in dopaminergic synapse; postsynaptic membrane; and presynaptic membrane. Biomarker of Parkinsonism; heroin dependence; high grade glioma; hyperprolactinemia; and hypertension. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; classic dopamine transporter deficiency syndrome; mild cognitive impairment; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 15.2), Kidney (RPKM 0.8) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc6a3 in Genome Data Viewer
    Location:
    1p11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (31537990..31578962, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (29709443..29750413, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (32323011..32363983, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene telomerase reverse transcriptase Neighboring gene CLPTM1-like Neighboring gene uncharacterized LOC134484979 Neighboring gene lysophosphatidylcholine acyltransferase 1 Neighboring gene uncharacterized LOC120098986

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nigrostriatal cell firing action on the dopamine transporter. Rodriguez M, et al. Eur J Neurosci, 2007 May. PMID 17561841
    2. The up-regulation of the striatal dopamine transporter's activity by cAMP is PKA-, CaMK II- and phosphatase-dependent. Page G, et al. Neurochem Int, 2004 Oct. PMID 15234104
    3. Grafts of adult subependymal zone neuronal progenitor cells rescue hemiparkinsonian behavioral decline. Richardson RM, et al. Brain Res, 2005 Jan 25. PMID 15680936
    4. Affinity labeling the dopamine transporter ligand binding site. Vaughan RA, et al. J Neurosci Methods, 2005 Apr 15. PMID 15763134
    5. Synthesis and pharmacology of 6-substituted benztropines: discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter. Simoni D, et al. J Med Chem, 2005 May 5. PMID 15857139

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pan-striatal reduction in the expression of the astrocytic dopamine transporter precedes the development of dorsolateral striatum dopamine-dependent incentive heroin seeking habits.
      Title: Pan-striatal reduction in the expression of the astrocytic dopamine transporter precedes the development of dorsolateral striatum dopamine-dependent incentive heroin seeking habits.
    2. Dopamine Transporter Knockout Rats Display Epigenetic Alterations in Response to Cocaine Exposure.
      Title: Dopamine Transporter Knockout Rats Display Epigenetic Alterations in Response to Cocaine Exposure.
    3. Inheritance of wild and truncated DAT alleles from grand-parents: Opposite transgenerational consequences on the behavioral phenotype in adolescent DAT heterozygous rats.
      Title: Inheritance of wild and truncated DAT alleles from grand-parents: Opposite transgenerational consequences on the behavioral phenotype in adolescent DAT heterozygous rats.
    4. Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats.
      Title: Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats.
    5. Brain glucose metabolism and dopamine transporter changes in rats with morphine-induced conditioned place preference.
      Title: Brain glucose metabolism and dopamine transporter changes in rats with morphine-induced conditioned place preference.
    6. Dopamine-transporter heterozygous rats carrying maternal wild-type allele are more vulnerable to the development of compulsive behavior.
      Title: Dopamine-transporter heterozygous rats carrying maternal wild-type allele are more vulnerable to the development of compulsive behavior.
    7. Effects of dopamine transporter changes in the ventral tegmental area of the midbrain on cognitive function in aged rats.
      Title: Effects of dopamine transporter changes in the ventral tegmental area of the midbrain on cognitive function in aged rats.
    8. [Influence of the DAT gene knockout on exchange of essential and toxic trace elements in rats].
      Title: [Influence of the DAT gene knockout on exchange of essential and toxic trace elements in rats].
    9. Own or dam's genotype? Classical colony breeding may bias spontaneous and stress-challenged activity in DAT-mutant rats.
      Title: Own or dam's genotype? Classical colony breeding may bias spontaneous and stress-challenged activity in DAT-mutant rats.
    10. Vapor Cannabis Exposure Promotes Genetic Plasticity in the Rat Hypothalamus.
      Title: Vapor Cannabis Exposure Promotes Genetic Plasticity in the Rat Hypothalamus.
    Submit: New GeneRIF Correction See all GeneRIFs (62)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables amine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amine binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables dopamine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dopamine:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dopamine:sodium symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables dopamine:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heterocyclic compound binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neurotransmitter transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables norepinephrine:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase 2A binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adenohypophysis development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dopamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dopamine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dopamine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within dopamine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dopamine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dopamine uptake ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hyaloid vascular plexus regression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hyaloid vascular plexus regression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within lactation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within monoamine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter uptake ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in norepinephrine uptake IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within prepulse inhibition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of dopamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cAMP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cocaine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ethanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to iron ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nicotine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of smell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in dopaminergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of flotillin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sodium-dependent dopamine transporter
    Names
    DA transporter
    DAT
    solute carrier family 6 (neurotransmitter transporter), member 3
    solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012694.2 → NP_036826.1  sodium-dependent dopamine transporter

      See identical proteins and their annotated locations for NP_036826.1

      Status: PROVISIONAL

      Source sequence(s)
      M80233
      UniProtKB/Swiss-Prot
      P23977
      UniProtKB/TrEMBL
      A6JUX6
      Related
      ENSRNOP00000047272.1, ENSRNOT00000040291.3
      Conserved Domains (1) summary
      cd11514
      Location:60 → 613
      SLC6sbd_DAT1; Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      31537990..31578962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23977.1 GenPept UniProtKB/Swiss-Prot:P23977

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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