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    nuf2.L NDC80 kinetochore complex component NUF2 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 398428, updated on 4-Jan-2025

    Summary

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    Official Symbol
    nuf2.L
    Official Full Name
    NDC80 kinetochore complex component NUF2 L homeolog
    Primary source
    Xenbase:XB-GENE-1001444
    Locus tag
    XELAEV_18023406mg
    See related
    EnsemblRapid:ENSXLAG00005012319 AllianceGenome:Xenbase:XB-GENE-1001444
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    nuf2; cdca1; ct106; nuf2r; nuf2-a; nuf2-b; cdca1-a
    Summary
    Predicted to act upstream of or within cell division. Predicted to be located in kinetochore and nucleus. Predicted to be part of Ndc80 complex. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma and pancreatic cancer. Orthologous to human NUF2 (NUF2 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See nuf2.L in Genome Data Viewer
    Location:
    chromosome: 4L
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (104495221..104510787)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (99222082..99237504)

    Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signaling 4 L homeolog Neighboring gene regulator of G-protein signaling 5 L homeolog Neighboring gene pre-B-cell leukemia homeobox 1 L homeolog Neighboring gene LIM homeobox transcription factor 1 alpha L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Measuring the stoichiometry and physical interactions between components elucidates the architecture of the vertebrate kinetochore. Emanuele MJ, et al. Mol Biol Cell, 2005 Oct. PMID 16079178, Free PMC Article
    2. The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. McCleland ML, et al. Genes Dev, 2003 Jan 1. PMID 12514103, Free PMC Article
    3. The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. McCleland ML, et al. Curr Biol, 2004 Jan 20. PMID 14738735
    4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Ndc80 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Ndc80 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinetochore protein Nuf2-A
    Names
    NUF2, NDC80 kinetochore complex component L homeolog
    NUF2, NDC80 kinetochore complex component, homolog
    cell division cycle-associated protein 1-A
    kinetochore spindle checkpoint protein Nuf2
    xNuf2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001088901.1 → NP_001082370.1  kinetochore protein Nuf2-A

      See identical proteins and their annotated locations for NP_001082370.1

      Status: PROVISIONAL

      Source sequence(s)
      AY168014
      UniProtKB/Swiss-Prot
      Q8AWF4
      UniProtKB/TrEMBL
      A0A1L8GN20, A0A974D0S9, A0A974D6S4
      Conserved Domains (2) summary
      COG1196
      Location:143 → 455
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam03800
      Location:3 → 146
      Nuf2; Nuf2 family

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      104495221..104510787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018256546.2 → XP_018112035.1  kinetochore protein Nuf2-A isoform X1

      UniProtKB/Swiss-Prot
      Q8AWF4
      UniProtKB/TrEMBL
      A0A1L8GN20, A0A974D0S9, A0A974D6S4
      Related
      ENSXLAP00005036122.1, ENSXLAT00005037022.1
      Conserved Domains (2) summary
      COG1196
      Location:143 → 455
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam03800
      Location:3 → 146
      Nuf2; Nuf2 family

    2. XM_041589211.1 → XP_041445145.1  kinetochore protein Nuf2-A isoform X1

      UniProtKB/Swiss-Prot
      Q8AWF4
      UniProtKB/TrEMBL
      A0A1L8GN20, A0A974D0S9, A0A974D6S4
      Related
      ENSXLAP00005036117.1, ENSXLAT00005037017.1
      Conserved Domains (2) summary
      COG1196
      Location:143 → 455
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam03800
      Location:3 → 146
      Nuf2; Nuf2 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8AWF4.1 GenPept UniProtKB/Swiss-Prot:Q8AWF4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.